scholarly journals Lidocaine administered at a continuous rate infusion does not impair left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam

2020 ◽  
Vol 10 ◽  
pp. 100151
Author(s):  
A.E.G.W. Marques ◽  
M.G. Marques ◽  
B.C.R. Silveira ◽  
S.P. Oliveira ◽  
I.G. Ferraz ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Left Ventricular ◽  
Systolic And Diastolic Function ◽  
Rate Infusion

Effect of a constant rate infusion of remifentanil hydrochloride on left ventricular systolic and diastolic function in propofol-anesthetized dogs

2018 ◽  
Vol 79 (12) ◽  
pp. 1261-1267 ◽  
Author(s):  
Marcel G. Marques ◽  
Carlos H. B. Cancelli ◽  
Carollina M. S. Fernandes ◽  
Bruna M. M. Games ◽  
Beatriz P. Floriano ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Left Ventricular ◽  
Constant Rate Infusion ◽  
Constant Rate ◽  
Anesthetized Dogs ◽  
Systolic And Diastolic Function ◽  
Rate Infusion

scholarly journals Conventional Echocardiography and Two-Dimensional Speckle Tracking in Healthy Sevoflurane-Anesthetized Dogs Undergoing Continuous Rate Infusion of Nalbuphine

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Marcel G. Marques ◽  
Ana Elisa G. W. Marques ◽  
Carlos E. de Siqueira ◽  
Élen A. P. de Sousa ◽  
Yan S. Ribeiro ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Speckle Tracking ◽  
Cardiovascular Effects ◽  
Left Ventricular ◽  
Two Dimensional ◽  
Hemodynamic Variables ◽  
Anesthetized Dogs ◽  
Systolic And Diastolic Function ◽  
Conventional Echocardiography ◽  
Rate Infusion

Nalbuphine is an agonist-antagonist opioid with adequate analgesic properties and few depressant effects on the respiratory system. However, there are no detailed reports available on cardiovascular effects of nalbuphine in dogs. The aim of this study was to assess the effects of a continuous rate infusion (CRI) of nalbuphine on left ventricular systolic and diastolic function of healthy sevoflurane-anesthetized dogs. Eighteen mixed-breed bitches aged 1–4 years and weighing 9.9 ± 3.8 kg were used. Dogs were randomly assigned to one of two groups: nalbuphine (GN, n = 9) and control (GC, n = 9). Anesthesia was induced and maintained with sevoflurane (2V%) followed by an intravenous (IV) bolus of nalbuphine (0.3 mg/kg) or 0.9% NaCl at equal volume and then CRI of nalbuphine (0.4 mg/kg/h) or 0.9% NaCl at an equal infusion rate. Echocardiographic and hemodynamic variables were determined at baseline and 20, 40, 60, and 80 minutes following start of CRI. No differences were found between groups for left ventricular systolic and diastolic variables obtained through conventional echocardiography and two-dimensional speckle tracking. Likewise, hemodynamic variables did not differ between groups. The E′/A′ ratio significantly increased at 20 minutes compared to baseline only in GN. Nalbuphine given at a CRI does not influence left ventricular systolic and diastolic function in healthy sevoflurane-anesthetized dogs.

Abstract 402: Vitamin C Deficiency Impairs Cardiac Function and Post-infarction Survival in the Mouse

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Adolfo G Mauro ◽  
Donatas Kraskauskas ◽  
Bassem M Mohammed ◽  
Bernard J Fisher ◽  
Eleonora Mezzaroma ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cardiac Function ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Coronary Artery Ligation ◽  
Artery Ligation ◽  
Additional Group ◽  
Gulonolactone Oxidase ◽  
Low Levels ◽  
Systolic And Diastolic Function

Introduction: L-gulonolactone oxidase (Gulo) is the rate limiting enzyme for Vitamin C (VitC) biosynthesis. Humans rely on dietary VitC for collagen synthesis, extracellular matrix formation, and tissue regeneration. VitC deficiency is an unrecognized condition and its role in cardiac homeostasis and post-acute myocardial infarction (AMI) remodeling is unknown. Hypothesis: Low levels of VitC impair cardiac function and tissue repair following AMI. Methods: Adult male Gulo -/- knockout mice (C57BL6 background, N=8) and control C57BL (N=8), which are able to synthesize VitC were used. VitC deficiency was maintained supplying low levels of VitC (30mg/l) to Gulo -/- mice in drinking water. Mice underwent M-mode and Doppler echocardiography to measure left ventricular (LV) diameters and wall thicknesses, fractional shortening (FS), E and A waves, E/A ratio, isovolumetric relaxation time (IRT) and myocardial performance index (MPI). Experimental AMI was induced by coronary artery ligation for 7 days. An additional group of Gulo -/- were mice supplemented with physiological levels of VitC (330 mg/l) and underwent AMI. Results: VitC deficient Gulo -/- mice exhibited significantly reduced LV wall thicknesses, reduced FS, and impaired diastolic function, measured as significantly reduced E/A ratio and longer IRT (Panel A, B & C). Following AMI, 100% (8/8) of deficient Gulo -/- mice died within 5 days. Supplementation with physiological levels of VitC significantly improved survival after AMI (Panel D). Conclusion: VitC deficiency impairs systolic and diastolic function. Moreover, VitC is critical for the post-AMI survival.

scholarly journals Left ventricular systolic and diastolic function during orthostatic heat stress

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Michael D Nelson ◽  
Luis A Altamirano‐Diaz ◽  
Stewart R Petersen ◽  
Timothy P Just ◽  
Darren DeLorey ◽  
...  
Keyword(s):  
Heat Stress ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Systolic And Diastolic Function
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