scholarly journals Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

2016 ◽  
Vol 176 ◽  
pp. 38-68 ◽  
Author(s):  
Vipul Yadav ◽  
Felipe Varum ◽  
Roberto Bravo ◽  
Esther Furrer ◽  
Daniela Bojic ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Targets ◽  
Inflammatory Bowel ◽  
Novel Therapeutic

New Insights into Inflammatory Bowel Disease Pathophysiology: Paving the Way for Novel Therapeutic Targets

2008 ◽  
Vol 9 (5) ◽  
pp. 413-418 ◽  
Author(s):  
Tommaso Stefanelli ◽  
Alberto Malesci ◽  
Alessandro Repici ◽  
Stefania Vetrano ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Targets ◽  
Inflammatory Bowel ◽  
Novel Therapeutic ◽  
The Way

scholarly journals Potential Novel Therapeutic Targets In Epilepsy From The View of Intestinal Comorbidities - Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Mi Jiang ◽  
Jia Li ◽  
Zhi Song
Keyword(s):  
Gene Expression ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Refractory Epilepsy ◽  
Therapeutic Targets ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Hub Genes ◽  
Inflammatory Bowel ◽  
Novel Therapeutic

Abstract Background: Epilepsy is a complicated neurological disorder with almost 30% refractory. Recent years, several studies showed that epilepsy is associated with its comorbidities by shared molecular mechanisms. However, the association of epilepsy and digestive comorbidities are still unclear. In this study, we aim to explore the association between inflammatory bowel disease (IBD) and epilepsy, and to find promising therapeutic targets for refractory epilepsy. Methods: Two gene expression profiles (GSE134697 and GSE59071) were selected from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by GEO2R and the DESeq2 package. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of intersection DEGs and Gene Set Enrichment Analysis (GSEA) were conducted by clusterProfiler package. The protein-protein interactions (PPI) network was established by using STRING and visualized by Cytoscape. Genes in the most significant module identified by MCODE plug-in were considered as candidate hub genes. Validation of hub genes were performed by using the GSE143272 dataset. Results: Cytokine-cytokine receptor interaction pathway is identified as a communal pathway between IBD and epilepsy. CXCL8, CXCR4 and ITGAX were identified as the hub genes. Conclusions: The identification of the communal pathway and hub genes in this study contributes to a potential novel therapeutic target in refractory epilepsy.

Novel therapeutic targets for inflammatory bowel disease

2017 ◽  
Vol 85 ◽  
pp. 103-116 ◽  
Author(s):  
Marjorie Argollo ◽  
Gionata Fiorino ◽  
Pieter Hindryckx ◽  
Laurent Peyrin-Biroulet ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Targets ◽  
Inflammatory Bowel ◽  
Novel Therapeutic

Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease

2009 ◽  
Vol 1173 (1) ◽  
pp. 350-356 ◽  
Author(s):  
Miyuki Nishimura ◽  
Yoshikazu Kuboi ◽  
Kenzo Muramoto ◽  
Tetsu Kawano ◽  
Toshio Imai
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Targets ◽  
Inflammatory Bowel ◽  
Novel Therapeutic

scholarly journals Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

2013 ◽  
Vol 19 (14) ◽  
pp. 1711-1747 ◽  
Author(s):  
Fiorella Biasi ◽  
Gabriella Leonarduzzi ◽  
Patricia I. Oteiza ◽  
Giuseppe Poli
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Targets ◽  
Disease Mechanisms ◽  
Inflammatory Bowel

scholarly journals Hydroxylases as therapeutic targets in inflammatory bowel disease

2013 ◽  
Vol 93 (4) ◽  
pp. 378-383 ◽  
Author(s):  
Eoin P Cummins ◽  
Glen A Doherty ◽  
Cormac T Taylor
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Targets ◽  
Inflammatory Bowel
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