scholarly journals The meninges: new therapeutic targets for multiple sclerosis

2015 ◽  
Vol 165 (2) ◽  
pp. 255-269 ◽  
Author(s):  
Abigail E. Russi ◽  
Melissa A. Brown
Keyword(s):  
Multiple Sclerosis ◽  
Therapeutic Targets ◽  
New Therapeutic Targets

scholarly journals Immunosenescence in multiple sclerosis: The identification of new therapeutic targets

2021 ◽  
pp. 102893
Author(s):  
María Dema ◽  
Herena Eixarch ◽  
Luisa M. Villar ◽  
Xavier Montalban ◽  
Carmen Espejo
Keyword(s):  
Multiple Sclerosis ◽  
Therapeutic Targets ◽  
New Therapeutic Targets

Therapeutic Targets for the Treatment of Comorbidities Associated with Epilepsy

2020 ◽  
Vol 13 (2) ◽  
pp. 85-93
Author(s):  
Kinjal Gangar ◽  
Lokesh Kumar Bhatt
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Neurological Disorders ◽  
Therapeutic Targets ◽  
Therapeutic Failure ◽  
Hyperactivity Disorder ◽  
Novel Targets ◽  
New Therapeutic Targets ◽  
Dual Mechanism ◽  
Seizure Suppression

One of the most common neurological disorders, which occurs among 1% of the population worldwide, is epilepsy. Therapeutic failure is common with epilepsy and nearly about 30% of patients fall in this category. Seizure suppression should not be the only goal while treating epilepsy but associated comorbidities, which can further worsen the condition, should also be considered. Treatment of such comorbidities such as depression, anxiety, cognition, attention deficit hyperactivity disorder and, various other disorders which co-exist with epilepsy or are caused due to epilepsy should also be treated. Novel targets or the existing targets are needed to be explored for the dual mechanism which can suppress both the disease and the comorbidity. New therapeutic targets such as IDO, nNOS, PAR1, NF-κb are being explored for their role in epilepsy and various comorbidities. This review explores recent therapeutic targets for the treatment of comorbidities associated with epilepsy.

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