Difficulties, guidelines and review of developing an acute rejection model after rat intestinal transplantation

2016 ◽  
Vol 36 ◽  
pp. 32-41 ◽  
Author(s):  
Ane Miren Andres ◽  
Monica Santamaria ◽  
Francisco Hernandez-Oliveros ◽  
Laura Guerra ◽  
Sergio Lopez ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Intestinal Transplantation

scholarly journals Erratum to: The challenge of acute rejection in intestinal transplantation

2013 ◽  
Vol 29 (6) ◽  
pp. 663-663
Author(s):  
E. Y. Yoshitoshi ◽  
A. Yoshizawa ◽  
E. Ogawa ◽  
M. Kaneshiro ◽  
N. Takada ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Intestinal Transplantation

Basiliximab decreases the incidence of acute rejection after intestinal transplantation

2002 ◽  
Vol 34 (3) ◽  
pp. 940-941 ◽  
Author(s):  
D.L. Sudan ◽  
S. Chinnakotla ◽  
S. Horslen ◽  
K. Iyer ◽  
I. Fox ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Intestinal Transplantation

scholarly journals Perioperative Infliximab Application Ameliorates Acute Rejection Associated Inflammation After Intestinal Transplantation

2010 ◽  
Vol 10 (11) ◽  
pp. 2431-2441 ◽  
Author(s):  
T. Pech ◽  
T. Finger ◽  
J. Fujishiro ◽  
M. Praktiknjo ◽  
I. Ohsawa ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Intestinal Transplantation

Acute Rejection after Pediatric Intestinal Transplantation

2017 ◽  
Vol 101 ◽  
pp. S81
Author(s):  
Nathaly Llore ◽  
Raffaele Girlanda ◽  
Matthew L Holzner ◽  
Ahmed Elsabbagh ◽  
Alexander Kroemer ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Intestinal Transplantation

scholarly journals The Proteomic Signature of Intestinal Acute Rejection in the Mouse

Metabolites ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 23
Author(s):  
Mihai Oltean ◽  
Jasmine Bagge ◽  
George Dindelegan ◽  
Diarmuid Kenny ◽  
Antonio Molinaro ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Intestinal Transplantation ◽  
Clinical Value ◽  
Post Transplantation ◽  
Altered Expression ◽  
Non Invasive ◽  
Or Groups ◽  
Tissue Homogenates ◽  
Proteome Changes ◽  
Alteration Pattern

Intestinal acute rejection (AR) lacks a reliable non-invasive biomarker and AR surveillance is conducted through frequent endoscopic biopsies. Although citrulline and calprotectin have been suggested as AR biomarkers, these have limited clinical value. Using a mouse model of intestinal transplantation (ITx), we performed a proteome-wide analysis and investigated rejection-related proteome changes that may eventually be used as biomarkers. ITx was performed in allogenic (Balb/C to C57Bl) and syngeneic (C57Bl) combinations. Graft samples were obtained three and six days after transplantation (n = 4/time point) and quantitative proteomic analysis with iTRAQ-labeling and mass spectrometry of whole tissue homogenates was performed. Histology showed moderate AR in all allografts post-transplantation at day six. Nine hundred and thirty-eight proteins with at least three unique peptides were identified in the intestinal grafts. Eighty-six proteins varying by >20% between time points and/or groups had an alteration pattern unique to the rejecting allografts: thirty-seven proteins and enzymes (including S100-A8 and IDO-1) were significantly upregulated whereas forty-nine (among other chromogranin, ornithine aminotransferase, and arginase) were downregulated. Numerous proteins showed altered expression during intestinal AR, several of which were previously identified to be involved in acute rejection, although our results also identified previously unreported proteome changes. The metabolites and downstream metabolic pathways of some of these proteins and enzymes may become potential biomarkers for intestinal AR.

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