The role of the skin microrelief in the contact behaviour of human skin: Contact between the human finger and regular surface textures

2013 ◽  
Vol 65 ◽  
pp. 81-90 ◽  
Author(s):  
J. van Kuilenburg ◽  
M.A. Masen ◽  
E. van der Heide
Keyword(s):  
Human Skin ◽  
Regular Surface ◽  
Surface Textures ◽  
Skin Contact ◽  
Contact Behaviour ◽  
Human Finger

scholarly journals The Role of Skin-to-Skin Contact and Breastfeeding on Atonic Postpartum Hemorrhage

2020 ◽  
Vol 11 (1) ◽  
pp. 1-11
Author(s):  
Wedad M. Almutairi ◽  
Susan M. Ludington ◽  
Mary T. Quinn Griffin ◽  
Christopher J. Burant ◽  
Ahlam E. Al-Zahrani ◽  
...  
Keyword(s):  
Postpartum Hemorrhage ◽  
Retrospective Chart Review ◽  
Skin Contact ◽  
Labor Duration ◽  
Third Stage Of Labor ◽  
Estimated Blood Loss ◽  
Third Stage ◽  
Skin To Skin ◽  
Increasing Trends

Objectives: were to (a) determine incidence of postpartum hemorrhage (PPH) in all women delivering between 2009 and 2015, and (b) determine the amount of Estimated Blood Loss (EBL) and duration of the third stage of labor in each subgroup for women with or without PPH, and (c) compare EBL and duration of 3rd stage of labor between subgroups in groups of women with or without PPH. Design: A retrospective chart review conducted using codes for atonic PPH. Setting: Records from a University based tertiary setting, 264 charts were reviewed and data from 154 charts were analyzed. One-way ANOVAs followed with post-hocs and a 2-way ANOVA were conducted. Results: PPH rate increased by 47.50% from 2009–2015. For women with PPH, EBL was lower in skin to skin contact (SSC) + Breastfeeding (BF) subgroup. For women without PPH, EBL was lower in SSC only subgroup. Third stage of labor duration was longer in women with PPH. Conclusions: Study confirmed the increasing trends of PPH due to uterine atony and proposed role of SSC and BF in decreasing EBL and shorten the duration of the 3rd stage of labor for PPH women, usefulness of SSC and BF as physiologic practices merit further study.

5-MOP Induced Protection Against Epidermal DNA Damage by Ultraviolet Radiation in Human Skin: The Role of the Skin Type

1991 ◽  
pp. 201-209
Author(s):  
Antony R. Young ◽  
Christopher S. Potten ◽  
Caroline A. Chadwick ◽  
Gillian M. Murphy ◽  
A. Jeffrey Cohen
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Human Skin ◽  
Skin Type

scholarly journals The role of fathers in the postpartum period: experiences with skin to skin method

2012 ◽  
Vol 25 (6) ◽  
pp. 914-920 ◽  
Author(s):  
Joaquín Jesús Blanca Gutiérrez ◽  
María del Rosario Ábalos Pérez ◽  
Maria Victoria Montes Aguilera ◽  
Soledad González Moreno
Keyword(s):  
Health Professionals ◽  
Qualitative Method ◽  
Simple Technique ◽  
Contact Method ◽  
Skin Contact ◽  
Father’S Role ◽  
Skin To Skin ◽  
Depth Interviews ◽  
Positive Results

OBJECTIVE: This study aimed at investigating the significance of the skin-to-skin contact method with fathers, looking at their own experiences with their newborns. METHODS: The information was collected through in-depth interviews with 14 fathers who had used the skin-to-skin contact method with their newborns, after a cesarean delivery. The technique utilized for data analysis was the qualitative method of content analysis. RESULTS: Four principal themes emerged from the data: the preparation for the skin-to-skin method, the experiences of the fathers, the father's role, and effects of the method on the baby. CONCLUSIONS: The investigations performed highlighted the importance of the involvement of health professionals in the use of this method, which leads to a series of positive results for the organization related to satisfaction. We conclude that the skin-to-skin method is a simple technique, recommended for positive results for fathers and their babies.

scholarly journals Expression of drug transporters in the human skin: comparison in different species and models and its implication for drug development

ADMET & DMPK ◽  
2017 ◽  
Vol 5 (2) ◽  
pp. 75 ◽  
Author(s):  
Hanan Osman-Ponchet ◽  
Alexandre Gaborit ◽  
Jean-Michel Linget ◽  
Claire E. Wilson
Keyword(s):  
Human Skin ◽  
Drug Absorption ◽  
Transdermal Delivery ◽  
Drug Transporters ◽  
Drug Distribution ◽  
Skin Surface ◽  
Pharmacological Intervention ◽  
Novel Targets

<p class="ADMETabstracttext">It is clear that many drug transporters (both ABCs and SLCs) are present in the human skin. Different in vitro skin models can be used to investigate the role of drug transporters in the skin despite quantitative differences in expression profile across species. P-gp was shown to have an important influence on transdermal drug absorption in the skin and to function in “absorptive” transport, carrying substrate drugs from the skin surface to the dermis. This observation might be used to modulate drug distribution inside the skin. If drugs can be retained in the epidermis compartment by inhibition of the transporters, such property of the drug would be beneficial for treatment of dermatological diseases. Therefore, it might be feasible to control transdermal delivery of drugs to specific locations in the skin, by modulating the function of the transporters in the skin. We are at the dawn of an exciting period where drug transporters might be novel targets for improvement of drug delivery to the skin and for pharmacological intervention.</p>

The role of TRPV1 channel in aged human skin

2012 ◽  
Vol 65 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Young Mee Lee ◽  
So Min Kang ◽  
Jin Ho Chung
Keyword(s):  
Human Skin ◽  
Trpv1 Channel

Evidence for the involvement of peripheral cold-sensitive TRPM8 channels in human cutaneous hygrosensation

2020 ◽  
Vol 318 (3) ◽  
pp. R579-R589 ◽  
Author(s):  
Oliver Typolt ◽  
Davide Filingeri
Keyword(s):  
Human Skin ◽  
Chemical Activation ◽  
The Body ◽  
Cold Sensitivity ◽  
Trpm8 Channel ◽  
Body Regions ◽  
Skin Cooling ◽  
Cold Sensitive ◽  
Skin Wetness

In contrast to other species, humans are believed to lack hygroreceptors for sensing skin wetness. Yet, the molecular basis of human hygrosensation is currently unknown, and it remains unclear whether we possess a receptor-mediated sensing mechanism for skin wetness. The aim of this study was to assess the role of the cutaneous cold-sensitive transient receptor potential melastatin-8 (TRPM8) channel as a molecular mediator of human hygrosensation. To this end, we exploited both the thermal and chemical activation of TRPM8-expressing cutaneous Aδ cold thermoreceptors, and we assessed wetness sensing in healthy young men in response to 1) dry skin cooling in the TRPM8 range of thermosensitivity and 2) application of the TRPM8 agonist menthol. Our results indicate that 1) independently of contact with moisture, a cold-dry stimulus in the TRPM8 range of activation induced wetness perceptions across 12 different body regions and those wetness perceptions varied across the body following regional differences in cold sensitivity; and 2) independently of skin cooling, menthol-induced stimulation of TRPM8 triggered wetness perceptions that were greater than those induced by physical dry cooling and by contact with an aqueous cream containing actual moisture. For the first time, we show that the cutaneous cold-sensing TRPM8 channel plays the dual role of cold and wetness sensor in human skin and that this ion channel is a peripheral mediator of human skin wetness perception.

scholarly journals Understanding the role of surface textures in improving the performance of boundary additives, part I: Experimental

2020 ◽  
Vol 146 ◽  
pp. 106243 ◽  
Author(s):  
Doris Nekesa Khaemba ◽  
Abdullah Azam ◽  
TianLong See ◽  
Anne Neville ◽  
Farnaz Motamen Salehi
Keyword(s):  
Surface Textures

Analysis of phases 1 and 2 metabolism enzymes in human skin suggests important role of phase 2 enzymes in the detoxification

2008 ◽  
Vol 180 ◽  
pp. S121 ◽  
Author(s):  
Van Luu-The ◽  
Daniel Duché ◽  
Corinne Ferraris ◽  
Jacques Leclaire ◽  
Fernand Labrie
Keyword(s):  
Human Skin ◽  
Phase 2 ◽  
Metabolism Enzymes ◽  
Phase 2 Enzymes
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