Transplantation Using Renal Grafts With Multiple Renal Arteries: A Putative Study on the Impact of Arterial Reconstruction Technique and Site of Implantation on Outcomes

2020 ◽  
Author(s):  
Sait M. Dogan ◽  
Gulec Dogan ◽  
Cenk Simsek ◽  
Gokalp Okut ◽  
Bayram Berktas ◽  
...  
Keyword(s):  
Renal Arteries ◽  
Reconstruction Technique ◽  
Arterial Reconstruction ◽  
Multiple Renal Arteries ◽  
Renal Grafts ◽  
The Impact

Robotic kidney transplant using renal grafts with multiple renal arteries has outcomes comparable to grafts with single artery

2019 ◽  
Vol 18 (1) ◽  
pp. e1019
Author(s):  
F.A. Zafar ◽  
A. Mallya ◽  
S.A. Nataraj ◽  
P. Wadhwa ◽  
P. Ghosh ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Renal Arteries ◽  
Multiple Renal Arteries ◽  
Renal Grafts

scholarly journals Scale dependence of galaxy biasing investigated by weak gravitational lensing: An assessment using semi-analytic galaxies and simulated lensing data

2018 ◽  
Vol 613 ◽  
pp. A15 ◽  
Author(s):  
Patrick Simon ◽  
Stefan Hilbert
Keyword(s):  
Gravitational Lensing ◽  
Spatial Scales ◽  
Scale Dependence ◽  
Reconstruction Technique ◽  
Weak Gravitational Lensing ◽  
Physical Scale ◽  
The Galaxy ◽  
Galaxy Bias ◽  
The Impact ◽  
Lens Galaxies

Galaxies are biased tracers of the matter density on cosmological scales. For future tests of galaxy models, we refine and assess a method to measure galaxy biasing as a function of physical scalekwith weak gravitational lensing. This method enables us to reconstruct the galaxy bias factorb(k) as well as the galaxy-matter correlationr(k) on spatial scales between 0.01hMpc−1≲k≲ 10hMpc−1for redshift-binned lens galaxies below redshiftz≲ 0.6. In the refinement, we account for an intrinsic alignment of source ellipticities, and we correct for the magnification bias of the lens galaxies, relevant for the galaxy-galaxy lensing signal, to improve the accuracy of the reconstructedr(k). For simulated data, the reconstructions achieve an accuracy of 3–7% (68% confidence level) over the abovek-range for a survey area and a typical depth of contemporary ground-based surveys. Realistically the accuracy is, however, probably reduced to about 10–15%, mainly by systematic uncertainties in the assumed intrinsic source alignment, the fiducial cosmology, and the redshift distributions of lens and source galaxies (in that order). Furthermore, our reconstruction technique employs physical templates forb(k) andr(k) that elucidate the impact of central galaxies and the halo-occupation statistics of satellite galaxies on the scale-dependence of galaxy bias, which we discuss in the paper. In a first demonstration, we apply this method to previous measurements in the Garching-Bonn Deep Survey and give a physical interpretation of the lens population.

Aberrant activation of complement system in renal grafts is mediated by cold storage

2021 ◽  
Author(s):  
Sorena Lo ◽  
Li Jiang ◽  
Savannah Stacks ◽  
Haixia Lin ◽  
Nirmala Parajuli
Keyword(s):  
Cold Storage ◽  
Complement System ◽  
Complement Activation ◽  
Renal Tubules ◽  
Renal Transplants ◽  
Reducing Conditions ◽  
Tnf Α ◽  
Renal Grafts ◽  
The Impact ◽  
The Complement System

Aberrant complement activation leads to tissue damage during kidney transplantation, and it is recognized as an important target for therapeutic intervention (6, 19, 35, 64). However, it is not clear whether cold storage (CS) triggers the complement pathway in transplanted kidneys. The goal of this study was to determine the impact of CS on complement activation in renal transplants. Male Lewis and Fischer rats were used, and donor rat kidneys were exposed to 4 h or 18 h of CS followed by transplantation (CS+Transplant). To study CS-induced effects, a group with no CS was included in which the kidney was removed and transplanted back to the same rat (autotransplantation, ATx). Complement proteins (C3 and C5b-9) were evaluated with western blotting (reducing and non-reducing conditions) and immunostaining. Western blot of renal extracts or serum indicated that the levels of C3 and C5b-9 increased after CS+Transplant compared to ATx. Quite strikingly, intracellular C3 was profoundly elevated within renal tubules after CS+Transplant but was absent in Sham or ATx groups, which showed only extratubular C3. Similarly, C5b-9 immunofluorescence staining of renal sections showed an increase in C5b-9 deposits in kidneys after CS+Transplant. Real-time PCR (SYBR Green) showed increased expression of CD11b and CD11c, components of complement receptors 3 and 4, respectively, as well as inflammatory markers such as TNF-α. In addition, recombinant TNF-α significantly increased C3 levels in renal cells. Collectively, these results demonstrate that CS activates the complement system in renal transplants.

scholarly journals Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era

Urology ◽  
2011 ◽  
Vol 77 (5) ◽  
pp. 1116-1121 ◽  
Author(s):  
Mark D. Tyson ◽  
Erik P. Castle ◽  
Edmund Y. Ko ◽  
Paul E. Andrews ◽  
Raymond L. Heilman ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Living Donor ◽  
Renal Arteries ◽  
Donor Kidney ◽  
Living Donor Kidney Transplantation ◽  
Multiple Renal Arteries ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

Conjoined arterial anastomosis; an aid in revascularizing donor kidneys with multiple renal arteries

1975 ◽  
Vol 42 (3) ◽  
pp. 247-253
Author(s):  
L. H. W. Banowsky ◽  
J. Kilpak ◽  
S. Loening ◽  
B. H. Stewart ◽  
R. A. Straffon ◽  
...  
Keyword(s):  
Renal Arteries ◽  
Multiple Renal Arteries ◽  
Arterial Anastomosis

Avoiding tibia physeal injury during double-bundle posterior cruciate ligament reconstruction

2018 ◽  
Vol 3 (1) ◽  
pp. 21-25
Author(s):  
Stockton Troyer ◽  
Nicolas G Anchustegui ◽  
Connor G Richmond ◽  
Peter C Cannamela ◽  
Aleksei Dingel ◽  
...  
Keyword(s):  
Posterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Tibial Tunnel ◽  
Double Bundle ◽  
Reconstruction Technique ◽  
Pcl Reconstruction ◽  
Turn Angle ◽  
Physeal Injury ◽  
The Impact ◽  
Killer Turn

BackgroundAnatomic studies of the paediatric posterior cruciate ligament (PCL) demonstrate that the tibial attachment spans the epiphysis, physis and metaphysis. To better reproduce the anatomy of the PCL and avoid direct physeal injury, a double-bundle PCL reconstruction technique that includes both an all-epiphysial and an all-metaphyseal tibial tunnel has been proposed. The purpose of this study was to evaluate tibial tunnel placement in a paediatric double-bundle PCL reconstruction technique that avoids direct physeal injury using a 3-D computer model.MethodsTen skeletally immature cadaveric knee specimens (ages 5–11) were used to create 3-D model reconstructions from CT scans. All-metaphyseal and all-epiphysial tibial tunnels were simulated with the goal of maintaining adequate spacing (≥2 mm) between the tibial physis and tunnels to avoid injury. The all-metaphyseal tunnel, simulated at sizes of 5, 6 and 7 mm, entered anteriorly, below the tibial tubercle (apophysis) and exited posteriorly in the metaphyseal PCL footprint, distal to the proximal tibial physis. Four-millimetre all-epiphysial proximal tibial tunnels were simulated to enter the epiphysis anteromedially and exit posteriorly at the central epiphysial region of the PCL footprint, proximal to the physis. The distance was measured from the all-metaphyseal tunnels to the physis posteriorly and from the all-epiphysial tunnels to the physis, both anteriorly and posteriorly.ResultsIn all specimens, the 4 mm all-epiphysial tunnel and the 5, 6 and 7 mm all-metaphyseal tunnels maintained adequate spacing, ≥2 mm from the physis. In the specimens aged 5–7 years, the 5, 6 and 7 mm all-metaphyseal tunnels measured a mean distance of 3.5, 2.8 and 2.5 mm from the physis, respectively. In the specimens aged 8–11 years, the 5, 6 and 7 mm all-metaphyseal tunnels measured a mean distance of 3.4, 2.9 and 2.6 mm from the physis. In the specimens aged 5–7 years, the all-epiphysial tunnel measured a mean of 2.1 mm to the physis anteriorly and a mean of 2.8 mm posteriorly. In the specimens aged 8–11 years, the all-epiphysial tunnel measured a mean of 2.2 mm to the physis anteriorly and 2.4 mm posteriorly.ConclusionThese computer-aided 3-D models of paediatric knees illustrate that 5, 6 and 7 mm all-metaphyseal tunnels as well as 4 mm all-epiphysial tunnels can be placed without direct injury to the proximal tibial physis. The margin of error for direct physeal injury is small, especially for the all-epiphysial tunnel. Further, the all-epiphysial tunnel, while reproducing the anatomy of the PCL epiphysial attachment, may also produce a more extreme ‘killer turn’ of the graft. Modifications to the all-epiphysial tunnel may be considered to reduce the impact of the high ‘killer turn’ angle on the tibia.Level of evidenceIV.

Sign in / Sign up

Export Citation Format

Share Document