Current Status of Uterus Transplantation and Approaches for Future Clinical Application in Japan

2018 ◽  
Vol 50 (9) ◽  
pp. 2783-2788 ◽  
Author(s):  
I. Kisu ◽  
K. Banno ◽  
Y. Matoba ◽  
M. Adachi ◽  
D. Aoki
2019 ◽  
Vol 8 (2) ◽  
pp. 245 ◽  
Author(s):  
Iori Kisu ◽  
Yu Liu ◽  
Gaowen Chen ◽  
Min Song ◽  
Cherry Chang ◽  
...  

Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. To date, three groups have performed UTx in humans in Asia, and many others are aiming for the clinical application of UTx with accumulation of basic experimental data. Therefore, it is likely that UTx will expand rapidly in Asia in the near future, although this will depend on ethical, social and religious views in each country. With this background, herein we summarize the current progress of UTx in East, Southeast and South Asia, with the purpose of increasing understanding of the current status of basic and clinical UTx research in each country and sharing progress and knowledge to ensure future development of UTx research in Asia.


2013 ◽  
Vol 100 (1) ◽  
pp. 280-294 ◽  
Author(s):  
Iori Kisu ◽  
Kouji Banno ◽  
Makoto Mihara ◽  
Nobuhiko Suganuma ◽  
Daisuke Aoki

Hematology ◽  
2002 ◽  
Vol 2002 (1) ◽  
pp. 10-34 ◽  
Author(s):  
Mark C. Walters ◽  
Arthur W. Nienhuis ◽  
Elliott Vichinsky

Abstract In this update, selected clinical features of sickle cell disease and their management are reviewed. In addition, the current status of interventions that have curative potential for sickle cell disease is discussed, with particular attention focused on indications, methodology, recent results, and challenges to wider clinical application. In Section I, Dr. Nienhuis describes recent improvements in vector technology, safety, and replacement gene expression that are creating the potential for clinical application of this technology. In Section II, Dr. Vichinsky reviews our current understanding of the pathophysiology and treatment of pulmonary injury in sickle cell disease. The acute and chronic pulmonary complications of sickle cell disease, modulators and predictors of severity, and conventional and novel treatment of these complications are discussed. In Section III, Dr. Walters reviews the current status of hematopoietic cell transplantation for sickle cell disease. Newer efforts to expand its availability by identifying alternate sources of stem cells and by reducing the toxicity of transplantation are discussed.


2019 ◽  
Vol 39 (4) ◽  
pp. 523-525 ◽  
Author(s):  
Yin Wang ◽  
Wei-wei Jiang ◽  
Nian-guo Dong

2009 ◽  
Vol 16 (5) ◽  
pp. 263-280 ◽  
Author(s):  
Richard N. Pierson ◽  
Anthony Dorling ◽  
David Ayares ◽  
Michael A. Rees ◽  
Jörg D. Seebach ◽  
...  

Author(s):  
Hyung-Doo Park

Context.— The clinical applications of point-of-care testing (POCT) are gradually increasing in many health care systems. Recently, POCT devices using molecular genetic method techniques have been developed. We need to examine clinical pathways to see where POCT can be applied to improve them. Objective.— To introduce up-to-date POCT items and equipment and to provide the content that should be prepared for clinical application of POCT. Data Sources.— Literature review based on PubMed searches containing the terms point-of-care testing, clinical chemistry, diagnostic hematology, and clinical microbiology. Conclusions.— If medical resources are limited, POCT can help clinicians make quick medical decisions. As POCT technology improves and menus expand, areas where POCT can be applied will also increase. We need to understand the limitations of POCTs so that they can be optimally used to improve patient management.


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