Clinical Outcomes of Living Liver Transplantation According to the Presence of Sarcopenia as Defined by Skeletal Muscle Mass, Hand Grip, and Gait Speed

2017 ◽  
Vol 49 (9) ◽  
pp. 2144-2152 ◽  
Author(s):  
N. Harimoto ◽  
T. Yoshizumi ◽  
T. Izumi ◽  
T. Motomura ◽  
N. Harada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Transplantation ◽  
Clinical Outcomes ◽  
Muscle Mass ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Hand Grip

scholarly journals Association of Sarcopenic Dysphagia with Underlying Sarcopenia Following Hip Fracture Surgery in Older Women

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1365 ◽  
Author(s):  
Ayano Nagano ◽  
Keisuke Maeda ◽  
Akio Shimizu ◽  
Shinsuke Nagami ◽  
Naohide Takigawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hip Fracture ◽  
Grip Strength ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Oral Intake ◽  
Hip Fracture Surgery ◽  
Hand Grip ◽  
Sarcopenic Dysphagia ◽  
Fracture Surgery

This study aimed to investigate the association between the development of dysphagia in patients with underlying sarcopenia and the prevalence of sarcopenic dysphagia in older patients following surgical treatment for hip fracture. Older female patients with hip fractures (n = 89) were studied. The data of skeletal muscle mass, hand-grip strength, and nutritional status were examined. The development of dysphagia postoperatively was graded using the Food Oral Intake Scale by a certified nurse in dysphagia nursing. The patients’ mean age was 85.9 ± 6.5 years. The prevalence of sarcopenia was 76.4% at baseline. Of the 89 patients, 11 (12.3%) and 12 (13.5%) had dysphagia by day 7 of hospitalization and at discharge, respectively. All patients who developed dysphagia had underlying sarcopenia. Lower skeletal muscle mass index (SMI) (<4.7 kg/m2) and grip strength (<8 kg) at baseline indicated a higher incidence of dysphagia on day 7 (p = 0.003 and Phi = 0.391) and at discharge (p = 0.001 and Phi = 0.448). Dysphagia developed after hip fracture surgery could be sarcopenic dysphagia, and worsening sarcopenia was a risk factor for dysphagia following hip fracture surgery. Clinicians and medical coworkers should become more aware of the risks of sarcopenic dysphagia. Early detection and preventive interventions for dysphagia should be emphasized.

scholarly journals ASSOCIATION BETWEEN GAIT SPEED MEASURED USING A WEARABLE DEVICE AND SARCOPENIA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S885-S886
Author(s):  
Min-gu Kang ◽  
Kwang-il Kim ◽  
Joon Koo Kang ◽  
Seong-Ji Kang ◽  
Hye-Kang Roh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Daily Life ◽  
Measurement Data ◽  
Lower Limbs ◽  
University Hospital ◽  
Speed Measurement ◽  
The Mean

Abstract As slow gait speed is a major feature of frailty and a diagnostic criterion of sarcopenia, gait speed measurement is widely used. Nowadays, with development of wearable devices, it is possible to measure daily-life gait speed without additional effort just by wearing the device. It is meaningful to measure daily-life gait speed and to analyze the association between the speed and sarcopenia. Participants were men over 50 years of age who visited the university hospital. Daily-life gait speed was checked using a smart belt (WELT) for 4 weeks. Afterwards, a survey about past medical history, usual gait speed measurement, handgrip strength measurement, and dual energy X-ray absorptiometry were performed. A total of 217,548 daily-life gait speed measurement data were analyzed for 106 participants. The mean daily-life gait speed was 1.23 ± 0.26 m/s. The mean age was 71.1 ± 7.6, and daily-life gait speed was significantly slower as people get older. (P&lt;0.001) Additionally, weekday gait speed (1.23 ± 0.26 m/s) was significantly faster than weekend gait speed (1.22 ± 0.26 m/s). (P&lt;0.001) Participants with sarcopenia (1.15 ± 0.25 m/s) had significantly slower mean daily-life gait speed than normal subjects (1.23 ± 0.26 m/s). (P&lt;0.001) In analyzing factors related to gait speed, age and skeletal muscle mass of lower limbs were significantly associated with mean daily-life gait speed. Additional information about the gait speed can be obtained by measuring daily-life gait speed, and the daily-life gait speed has a significant association with the skeletal muscle mass of lower limbs.

The Independent Relationship Between Leg Skeletal Muscle Mass Asymmetry and Gait Speed in Community-Dwelling Older Adults

2020 ◽  
Vol 28 (6) ◽  
pp. 943-951
Author(s):  
Chiharu Iwasaka ◽  
Tsubasa Mitsutake ◽  
Etsuo Horikawa
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Asymmetry Index ◽  
Mass Asymmetry ◽  
Appendicular Skeletal Muscle ◽  
Skeletal Muscle Mass Index ◽  
Appendicular Skeletal Muscle Mass

Objectives: To investigate the relationship between leg skeletal muscle mass asymmetry and usual gait speed in older adults. Methods: The subjects were 139 community-dwelling older adults. The asymmetry index was calculated using the leg skeletal muscle mass index (LSMI) values of both legs. The subjects were divided into “large” and “small” asymmetry groups based on the asymmetry index. The relationship between asymmetry and gait speed was analyzed using a linear regression model. The appendicular skeletal muscle mass index and LSMI were included as adjustment variables in the analysis. Results: The asymmetry index and having a “large” asymmetry were independently related to gait speed, even after adjusting for covariates such as appendicular skeletal muscle mass index and LSMI. Discussion: Leg skeletal muscle mass asymmetry was related to gait speed independently of the appendicular skeletal muscle mass index and LSMI values. A skeletal muscle mass evaluation among older adults should include an assessment of the total skeletal muscle mass and its asymmetry.

scholarly journals Effect of Handgrip Strength on Clinical Outcomes of Patients with Hepatocellular Carcinoma Treated with Lenvatinib

2020 ◽  
Vol 10 (16) ◽  
pp. 5403
Author(s):  
Yurika Kotoh ◽  
Issei Saeki ◽  
Takahiro Yamasaki ◽  
Ryo Sasaki ◽  
Norikazu Tanabe ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Skeletal Muscle ◽  
Prognostic Factors ◽  
Clinical Outcomes ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Handgrip Strength ◽  
Significant Prognostic Factor ◽  
Skeletal Muscle Index ◽  
The Individual

Previous studies have reported prognostic factors for hepatocellular carcinoma (HCC) patients receiving lenvatinib; however, no studies have evaluated the effects of both handgrip strength and skeletal muscle mass on the clinical outcomes. Therefore, this retrospective study investigated the individual effect of handgrip strength, skeletal muscle mass, and sarcopenia on clinical outcomes of 53 HCC patients treated with lenvatinib. Before receiving lenvatinib, handgrip strength and skeletal muscle index (SMI) were measured. Low handgrip strength and muscle depletion were defined as <26 and <18 kg and SMI <42 and SMI <38 cm2/m2 in men and women, respectively. Sarcopenia was defined as having low handgrip strength and muscle depletion. Multivariate analysis identified modified albumin–bilirubin grade 1–2a (p = 0.010), Barcelona Clinic Liver Cancer stage A–B (p = 0.011), and absence of low handgrip strength (p = 0.015) as favorable prognostic factors for survival. Furthermore, sarcopenia was an independent significant prognostic factor for survival. Time to treatment failure was associated with handgrip strength and sarcopenia. Our findings suggest that handgrip strength may be a useful marker of clinical outcomes in HCC patients treated with lenvatinib.

SUN-P072: Low Skeletal Muscle Mass is Associated with Increased Hospital Costs in Patients with Cirrhosis Listed for Liver Transplantation

2017 ◽  
Vol 36 ◽  
pp. S80
Author(s):  
J. Van Vugt ◽  
S. Buettner ◽  
L. Alferink ◽  
N. Bossche ◽  
R. de Bruin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Transplantation ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Hospital Costs

Advanced Glycation End Product Accumulation Is Associated With Low Skeletal Muscle Mass, Weak Muscle Strength, and Reduced Bone Density: The Nagahama Study

2018 ◽  
Vol 74 (9) ◽  
pp. 1446-1453 ◽  
Author(s):  
Yasuharu Tabara ◽  
Tome Ikezoe ◽  
Mikihiro Yamanaka ◽  
Kazuya Setoh ◽  
Hiroaki Segawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
General Population ◽  
Muscle Mass ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Lower Limbs ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Usual Gait Speed

Abstract Background The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and lower limbs and usual gait speed were measured in a portion of older (≥60 years of age) participants (n = 1,934). The speed of sound (SOS) in the calcaneal bone was assessed via a quantitative ultrasound technique. Results In the total population, the frequency of low skeletal muscle mass linearly increased with the SAF-AGE quartiles (Q1: 14.2%, Q2: 16.1%, Q3: 21.1%, Q4: 24.8%; p < .001), and this association was independent of covariates including glycemic traits (Q4: odds ratio [OR] = 1.48, p < .001). The association between the highest SAF-AGE quartile and low skeletal muscle mass remained significant in the older subpopulation (OR = 1.85, p = .002). A similar but weak association was observed for low SOS (Q1: 8.9%, Q2: 8.3%, Q3: 10.4%, Q4: 12.2%; p < .001). Similar inverse associations were also observed with grip strength (OR = 1.98, p = .003), hip flexion strength (OR = 1.50, p = .012), and hip abduction strength (OR = 1.78, p = .001), but not with usual gait speed. Conclusion Accumulation of AGEs might be a deleterious factor for musculoskeletal properties.

scholarly journals The Association of Sarcopenia and Bone Mineral Densitometry in a Small Population of Turkish Elderly (P21-048-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Umut Safer ◽  
Vildan Binay Safer
Keyword(s):  
Skeletal Muscle ◽  
Elderly Patients ◽  
Grip Strength ◽  
Muscle Mass ◽  
Bone Mineral ◽  
Conflict Of Interest ◽  
Skeletal Muscle Mass ◽  
Walking Speed ◽  
Hand Grip ◽  
Bone Mineral Densitometry

Abstract Objectives Mortality rate of hip fracture is 18%-33% in following year. Epidemiological studies showed that sarcopenia is associated with mortality, morbidity and functional loss. Little is known about sarcopenia diagnostic criteria (ESPEN 2009) and bone mineral densitometry (BMD) scores in Turkish Elderly Population. Methods In this single centered observational study, elderly patients without cognitive impairment underwent assessment. Demographic features, mini nutrition assessment- sort form (MNA-sf) score, BMD, hand grip strength, 5 meter walking speed, skeletal muscle mass(SMM) and skeletal muscle mass index (SMM/Height 2) were recorded. We assessed sarcopenia criteria and BMD score relation. Results Forty-seven patients were fulfills inclusion criteria and underwent assessment. Mean age was 75.7661.03 and 63.8% were female. Three of all were sarcopenic according to ESPEN 2009 guidelines. 83% were normal and 17% were at malnutrition risk according to MNA-sf score. Hand grip straight (r¼0.286, p¼0.05) and SMM (r¼0.38, p¼0.011) were significantly positive correlates with femur total T score but there were no correlations between SMM index and 5 meters walking speed. Conclusions This preliminary study showed relations between skeletal muscle mass, hand grip strength and femur total BMD score in a small Turkish Elderly Patients Population. Sarcopenia and osteoporosis relation in Turkish Population should be assessed in multicentre large population-based study. Funding Sources Conflict of Interest: No conflict of interest, Fund: None.

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