A Novel Biomarker for Post-Transplant Recurrent IgA Nephropathy

2017 ◽  
Vol 49 (3) ◽  
pp. 541-545 ◽  
Author(s):  
S. Temurhan ◽  
S.U. Akgul ◽  
Y. Caliskan ◽  
A.S. Artan ◽  
C. Kekik ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Post Transplant ◽  
Recurrent Iga Nephropathy

scholarly journals Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents

2017 ◽  
Vol 45 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Rupali S. Avasare ◽  
Paul E. Rosenstiel ◽  
Ziad S. Zaky ◽  
Demetra S. Tsapepas ◽  
Gerald B. Appel ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Renal Allograft ◽  
Age Of Onset ◽  
Recurrent Disease ◽  
Medical Center ◽  
Multivariable Analysis ◽  
Columbia University ◽  
Post Transplant ◽  
Time To Recurrence ◽  
Recurrent Iga Nephropathy

Background: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. Methods: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to recurrent IgAN. Secondary outcomes were a composite of doubling of creatinine or allograft failure, and recurrent IgAN as a cause of allograft dysfunction. Results: Of the 62 patients, 14 had recurrent IgAN in the allograft. Mean time to recurrence was 2.75 years. Those with recurrent disease were younger at the time of native kidney biopsy (29 vs. 41 years, p < 0.0009). Black race and Hispanic ethnicity composed a higher proportion of the recurrent disease group. On multivariable analysis, significant predictors of recurrent IgAN included age at diagnosis (hazards ratio (HR) 0.911, 95% CI 0.85-0.98), burden of crescents on native biopsy (HR 1.21 per 10% increase in crescents, 95% CI 1.00-1.47) and allograft rejection (HR 3.59, 95% CI 1.10-11.7). Conclusions: Features of native IgAN can help predict the risk of recurrent disease in the renal allograft. In particular, immunologically active disease represented by earlier age of onset and greater burden of crescents on native biopsy is more likely to recur after transplant.

scholarly journals Clinical Predictors and Prognosis of Recurrent IgA Nephropathy in the Kidney Allograft

2021 ◽  
Author(s):  
Catherine R. Kavanagh ◽  
Francesca Zanoni ◽  
Rita Leal ◽  
Namrata G. Jain ◽  
Megan Nicole Stack ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Clinical Predictors ◽  
Kidney Allograft ◽  
Recurrent Iga Nephropathy

scholarly journals Recurrent IgA nephropathy after renal transplantation despite immunosuppressive regimens with mycophenolate mofetil

2005 ◽  
Vol 20 (6) ◽  
pp. 1214-1221 ◽  
Author(s):  
Arun Chandrakantan ◽  
Piti Ratanapanichkich ◽  
Mowaffaq Said ◽  
Catherine V. Barker ◽  
Bruce A. Julian
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplantation ◽  
Iga Nephropathy ◽  
Recurrent Iga Nephropathy

A clinicopathological study of recurrent IgA nephropathy following renal transplantation in children

Nephrology ◽  
2003 ◽  
Vol 8 (s4) ◽  
pp. A115-A115
Author(s):  
Hiroko CHIKAMOTO ◽  
Motoshi HATTORI ◽  
Shigeru HORITA ◽  
Toshihiro SAWAI ◽  
Tae OHMORI ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Iga Nephropathy ◽  
Clinicopathological Study ◽  
Recurrent Iga Nephropathy

scholarly journals Immunoglobulin A (IgA) Nephropathy in Protocol Graft Kidney Biopsy done at six months Post Transplantation in a Tertiary Care Center Hospital of Nepal

2017 ◽  
Vol 6 (1) ◽  
pp. 6-11
Author(s):  
Midhan Shrestha ◽  
Dibya Singh Shah
Keyword(s):  
Iga Nephropathy ◽  
Care Center ◽  
Tertiary Care ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
University Teaching ◽  
Time Interval ◽  
Post Transplantation ◽  
Protocol Biopsy ◽  
Post Transplant

Background: Renal transplantation is the treatment of choice for end stage renal disease. The focus of interest has been to increase the life of the transplanted graft. Recurrence of native kidney disease or occurrence of denovo glomerulonephritis has adverse effects in graft survival. Protocol graft biopsy done at fixed time interval after transplantation aids in early identification of post-transplant glomerulonephritis before development of clinical signs and symptoms. This study describes the incidence of post-transplant IgA Nephropathy in protocol renal graft biopsies done at six months post- transplantation.Materials and Methods: This is a hospital based observational descriptive study, done in Tribhuvan University Teaching Hospital, Kathmandu, Nepal, a tertiary medical referral center in the capital. Protocol biopsy of the graft kidney was performed at six months post-transplantation in all recipients who underwent kidney transplantation in this hospital between 2071 Kartik and 2072 Ashwin.Results: Protocol biopsy was performed in total 47 recipients. Mean age of the recipients was 33.7 years ±10.83 years. The study population consisted of 33 (70.2%) male and 14 (29.8%) female recipients. IgA Nephropathy was present in 6 (12.8%) recipients.Conclusion: Our study demonstrates that IgA Nephropathy does occur in patients with stable GFR and without any clinical or laboratory abnormalities. Protocol biopsy is valuable in detection of early histologic abnormalities before onset of clinical manifestations, thus helping in prompt management with aim to prolong the graft survival.Journal of Nobel Medical CollegeVolume 6, Number 1, Issue 10 (January-June, 2017)

scholarly journals A case of recurrent IgA nephropathy complicated with de novo membranous nephropathy in the graft.

1984 ◽  
Vol 73 (12) ◽  
pp. 1856-1860 ◽  
Author(s):  
Takehisa YURI ◽  
Keita TATEISHI ◽  
Naoyasu SUGISHITA ◽  
Yoshihiro FUKUDA ◽  
Yoshio TANI ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
De Novo ◽  
Recurrent Iga Nephropathy

scholarly journals SP811THE OUTCOMES OF SECOND TRANSPLANTATION IN RECURRENT IGA NEPHROPATHY

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii645-iii646
Author(s):  
Chung Hee Baek ◽  
Hyosang Kim ◽  
Won Seok Yang ◽  
Woo Seong Huh ◽  
Yu Seun Kim ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Second Transplantation ◽  
Recurrent Iga Nephropathy

Recurrent IgA nephropathy in renal transplant allografts

2001 ◽  
Vol 38 (3) ◽  
pp. 588-596 ◽  
Author(s):  
Angela Yee Moon Wang ◽  
Fernand MacMoune Lai ◽  
Alex Wai-Yin Yu ◽  
Peggo Kwok Wai Lam ◽  
Kai Ming Chow ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Iga Nephropathy ◽  
Recurrent Iga Nephropathy
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