scholarly journals Ex Vivo Perfusion Characteristics of Donation After Cardiac Death Kidneys Predict Long-Term Graft Survival

2016 ◽  
Vol 48 (10) ◽  
pp. 3251-3260 ◽  
Author(s):  
M. Sevinc ◽  
S. Stamp ◽  
J. Ling ◽  
N. Carter ◽  
D. Talbot ◽  
...  
Keyword(s):  
Graft Survival ◽  
Cardiac Death ◽  
Ex Vivo ◽  
Donation After Cardiac Death ◽  
Ex Vivo Perfusion

Development of a Prolonged Warm Ex Vivo Perfusion Model for Kidneys Donated after Cardiac Death

2017 ◽  
Vol 40 (6) ◽  
pp. 265-271 ◽  
Author(s):  
Daniel Urcuyo ◽  
Matthew F. Blum ◽  
Qiang Liu ◽  
Ahmed Nassar ◽  
Laura D. Buccini ◽  
...  
Keyword(s):  
Vascular Resistance ◽  
Whole Blood ◽  
Cardiac Death ◽  
Ex Vivo ◽  
Donation After Cardiac Death ◽  
Donor Pool ◽  
Ex Vivo Perfusion ◽  
Perfusion Model ◽  
Renal Grafts ◽  
Kidney Perfusion

Purpose Ex vivo perfusion of marginal kidney grafts offers the chance to expand the donor pool, but there is no current clinical standard for the prolonged warm perfusion of renal grafts. This exploratory pilot study seeks to identify a stable ex vivo kidney perfusion model that can support low intravascular resistance and preserve histologic architecture in a porcine donation after cardiac death (DCD) model. Methods 15 kidneys were preserved in 1 of 3 settings: normothermic whole blood (NT-WB), normothermic Steen Solution™ (XVIVO Perfusion) with whole blood (NT-Steen/WB), or subnormothermic Steen Solution™ at 21°C (SNT-Steen). Kidneys were primarily assessed using hemodynamic parameters and histologic analysis. Results NT-WB perfusion resulted in high vascular resistance and glomerular necrosis. NT-Steen/WB and SNT-Steen resistance ranged between 0.18–0.45 mmHg/mL per minute and 0.25–0.53 mmHg/mL per minute, respectively, enabling stable perfusion for up to 24 hours. NT-Steen/WB demonstrated tubular and glomerular necrosis, while the histologic architecture of SNT-Steen was preserved with the exception of numerous proteinaceous casts. Conclusions Our results suggest that ex vivo kidney perfusion with Steen Solution™ at 21°C supports low and stable vascular resistance and provides adequate histologic preservation during 24-hour perfusion.

Ex Vivo Lung Evaluation of Prearrest Heparinization in Donation After Cardiac Death

2013 ◽  
Vol 257 (3) ◽  
pp. 534-541 ◽  
Author(s):  
Pablo G. Sanchez ◽  
Gregory J. Bittle ◽  
Katrina Williams ◽  
Chetan Pasrija ◽  
Kai Xu ◽  
...  
Keyword(s):  
Cardiac Death ◽  
Ex Vivo ◽  
Donation After Cardiac Death

Combined Predictive Value of ECD Criteria for Long-Term Graft Survival of Kidneys From Donors After Cardiac Death.

2014 ◽  
Vol 98 ◽  
pp. 71
Author(s):  
M. Kusaka ◽  
Y. Kubota ◽  
H. Takahashi ◽  
N. Fukami ◽  
H. Sasaki ◽  
...  
Keyword(s):  
Graft Survival ◽  
Predictive Value ◽  
Cardiac Death

Nonanastomotic Biliary Strictures After Liver Transplantation

2020 ◽  
Vol 86 (10) ◽  
pp. 1363-1367
Author(s):  
Takahiro Ito ◽  
Mina Botros ◽  
Antony Aziz ◽  
Jacob G. Guorgui ◽  
Vatche G. Agopian ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Multivariate Analysis ◽  
Graft Survival ◽  
Odds Ratio ◽  
Cardiac Death ◽  
Donation After Cardiac Death ◽  
Biliary Strictures ◽  
Artery Thrombosis ◽  
Biliary Anastomosis ◽  
The Impact

Biliary strictures constitute a major source of morbidity and mortality following liver transplantation (LT). However, studies on the impact of nonanastomotic biliary strictures (NABS) on grafts after LT are limited. 649 patients who underwent LT between January 2013 and June 2017 at our center were retrospectively analyzed and 2.6% (n = 17) of the recipients developed NABS following LT. There were no differences between recipients with and without NABS in indication of LT, graft ischemia time, and type of biliary anastomosis. The incidence of post-LT hepatic artery thrombosis (HAT) (odds ratio [OR]: 15.75, P < .001) and the use of livers from donation after cardiac death (DCD) donors (OR: 8.292, P = .004) were identified as independent significant predictors of NABS by multivariate analysis. Graft survival in those with NABS was significantly worse than in patients without NABS (1-, 3-, and 5-years survival: 64.7%, 57.5%, 0%, vs. 89.8%, 84.0%, 76.4%, P < .001). In conclusion, while the incidence of NABS in our study was relatively low compared to previous reports, NABS was still found to be associated with poor graft survival. Special attention should be paid to NABS occurrence in grafts that develop HAT as well as those from DCD donors.

LIVER TRANSPLANTATION USING DONATION AFTER CARDIAC DEATH DONORS: SINGLE-CENTRE LONG-TERM OUTCOME

2010 ◽  
Vol 90 ◽  
pp. 407
Author(s):  
W. Jassem ◽  
D. Chasiotis ◽  
T. Cherian ◽  
S. Khorsandi ◽  
D. Davila ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Cardiac Death ◽  
Donation After Cardiac Death ◽  
Single Centre ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Lung transplantation with donation after cardiac death donors: Long-term follow-up in a single center

2010 ◽  
Vol 139 (5) ◽  
pp. 1306-1315 ◽  
Author(s):  
Nilto C. De Oliveira ◽  
Satoru Osaki ◽  
James D. Maloney ◽  
Keith C. Meyer ◽  
Takushi Kohmoto ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Cardiac Death ◽  
Donation After Cardiac Death ◽  
Single Center ◽  
Long Term Follow Up

Factors Affecting Graft Survival After Liver Transplantation from Donation After Cardiac Death Donors

2006 ◽  
Vol 82 (12) ◽  
pp. 1683-1688 ◽  
Author(s):  
Kwang-Woong Lee ◽  
Christopher E. Simpkins ◽  
Robert A. Montgomery ◽  
Jayme E. Locke ◽  
Dorry L. Segev ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Cardiac Death ◽  
Donation After Cardiac Death ◽  
Factors Affecting
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