Intraoperative Portal Flow of Less Than 1 Liter per Minute After Orthotopic Liver Transplantation Is Not Associated Per Se With an Increased Rate of Early Graft Dysfunction

2016 ◽  
Vol 48 (7) ◽  
pp. 2495-2498 ◽  
Author(s):  
M. Gastaca ◽  
M. Prieto ◽  
A. Valdivieso ◽  
P. Ruiz ◽  
A. Ventoso ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Graft Dysfunction ◽  
Portal Flow ◽  
Early Graft ◽  
Per Se ◽  
Early Graft Dysfunction

PP-010 Serum hepcidin: a predictor of early graft dysfunction following orthotopic liver transplantation?

Gut ◽  
2010 ◽  
Vol 59 (Suppl 1) ◽  
pp. A44.1-A44
Author(s):  
R Desai ◽  
D Ward ◽  
M Brookes ◽  
C Tselepis ◽  
A Holt ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Graft Dysfunction ◽  
Serum Hepcidin ◽  
Early Graft ◽  
Early Graft Dysfunction

scholarly journals Postreperfusion liver biopsy as predictor of early graft dysfunction and survival after orthotopic liver transplantation

2022 ◽  
Author(s):  
Esteban Fuentes-Valenzuela ◽  
Javier Tejedor-Tejada ◽  
Félix García-Pajares ◽  
Beatriz Madrigal Rubiales ◽  
Rodrigo Nájera-Muñoz ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Biopsy ◽  
Orthotopic Liver Transplantation ◽  
Graft Dysfunction ◽  
Early Graft ◽  
Early Graft Dysfunction

M1022 Serum Hepcidin: A Marker of Early Graft Dysfunction Following Orthotopic Liver Transplantation?

2010 ◽  
Vol 138 (5) ◽  
pp. S-824
Author(s):  
Rajeev Desai ◽  
Douglas G. Ward ◽  
Matthew J. Brookes ◽  
Chris Tselepis ◽  
Andrew P. Holt ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Graft Dysfunction ◽  
Serum Hepcidin ◽  
Early Graft ◽  
Early Graft Dysfunction

scholarly journals Early Graft Dysfunction after Live Donor Liver Transplantation: It’s time to redefine?

2021 ◽  
Author(s):  
Viniyendra Pamecha ◽  
Bramhadatta Pattnaik ◽  
Piyush Kumar Sinha ◽  
Nilesh Sadashiv Patil ◽  
Shridhar Vasantrao Sasturkar ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Live Donor Liver Transplantation ◽  
Live Donor ◽  
Graft Dysfunction ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Live Donor Liver ◽  
Early Graft ◽  
Early Graft Dysfunction

Early Graft Dysfunction Evaluation by Indocyanine Green Plasma Clearance Rate in the Immediate Postoperative Period After Liver Transplantation

2020 ◽  
Vol 52 (5) ◽  
pp. 1336-1339
Author(s):  
Esteban Horacio Gonzalez ◽  
Lucas Souto Nacif ◽  
Alex Jones Flores Cassenote ◽  
Rafael Soares Pinheiro ◽  
Vinicius Rocha-Santos ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Indocyanine Green ◽  
Postoperative Period ◽  
Clearance Rate ◽  
Plasma Clearance ◽  
Graft Dysfunction ◽  
Early Graft ◽  
Early Graft Dysfunction

scholarly journals Evaluation of Early Renal Allograft Dysfunction from Living Donors among Egyptian Patients (Histopathological and Immunohistochemical Study)

2021 ◽  
Vol 9 (A) ◽  
pp. 328-335
Author(s):  
Maha Emad El-dein ◽  
Sawsan A. A. Fadda ◽  
Samia M. Gabal ◽  
Amr M. Shaker ◽  
Wael M. Mohamad
Keyword(s):  
Drug Toxicity ◽  
Renal Allograft ◽  
Single Case ◽  
The Other ◽  
Graft Dysfunction ◽  
Post Transplantation ◽  
Early Graft ◽  
Per Se ◽  
Early Graft Dysfunction ◽  
C4d Staining

BACKGROUND: Early renal graft dysfunction is a major problem in the early post-transplantation period and is considered a major cause of graft loss. Clinical diagnosis based on the clinical criteria alone is unreliable; therefore, biopsy remains the gold standard to differentiate between rejection and non-rejection causes. AIM: This study was designed to identify and differentiate between causes of early graft dysfunction during the first post-transplantation month and to correlate between histological lesions and immunohistochemistry (IHC) for accurate diagnosis and a better outcome. MATERIALS AND METHODS: A total of 163 renal allograft biopsies, performed in the first post-transplantation month over 6 years, were included in the study. New sections were prepared from the paraffin blocks and stained with conventional stains. Additional sections were prepared and treated by complement fragment 4d (C4d) and cluster differentiation 3 (CD3) antibodies for IHC evaluation. RESULTS: All the studied cases were from living donors. The mean patient age was 39 years with predominant males. The clinical indication for most biopsies (94.5%) was impaired graft function. Acute rejection (AR) was the main diagnostic category observed in (98/163, 60.1%); out of which, T cell-mediated rejection (TCMR) was observed in (62/98, 63.2%). Drug toxicity was suspected in (53/163, 32.5%), acute tubular injury (ATI) not otherwise specified (nos) in (21/163, 12.9%), and other lesions including thrombotic microangiopathy were observed in the remaining biopsies. The most common cause of graft dysfunction in the 1st and 2nd weeks was AR representing. A significant correlation was seen between mild glomerulitis (g1) and mild peritubular capillaritis (PTC) 1, on the one side, and negative C4d staining, on the other side. No significant correlation was seen between moderate glomerulitis (g2) and moderate ptc2 at one side and positive C4d staining at the other side reflecting the poor association between the microvascular inflammation (“g” and “ptc” scores) and C4d positivity (r = 0.2). Missed mild tubulitis (t1) was found in a single case and missed moderate tubulitis (t2) was found in a single case detected by CD3 IHC. CONCLUSION: AR and drug toxicity account for the majority of early graft dysfunction, however, other pathological lesions, per se or coincide with them may be the cause. The significance of g2 per se as a marker for diagnosis of antibody-mediated rejection requires further study. Considering C4d score 1 (by IHC) positive; also requires further study with follow-up.

scholarly journals The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Qiong-Yue Zhang ◽  
Qiong-Fang Zhang ◽  
Da-Zhi Zhang
Keyword(s):  
Liver Transplantation ◽  
Survival Rate ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Graft Dysfunction ◽  
Outcome Indicators ◽  
Significant Difference ◽  
Early Graft ◽  
The Impact ◽  
Early Graft Dysfunction

Background and Aims. Liver transplantation is one of the most effective treatments for end-stage liver disease as well as for cases of acute liver failure. Facing organ donor shortage, liver transplant teams had to use marginal organs. Thus, increasing availability is a key concern of donor liver grafts including steatotic livers. However, the use of steatotic liver is still controversial. The aim of this systematic review and meta-analysis was to analyze the impact of steatosis on the outcome of liver transplantation. Methods. We searched PubMed, Cochrane Library, Embase, Web of knowledge, and so on for studies published through May 31, 2018, in which patients experienced liver transplantation using fatty liver. All studies extracted outcome indicators, and we draw conclusions by contrasting outcome indicators in different groups of steatosis. Odds ratios and 95% confidence intervals were calculated. P<0.05 was considered as statistically significant difference. Results. 19 publications were included. There was no significant difference between the group of no steatosis and mild group in primary nonfunction rate (P=0.605) or early graft dysfunction rate (P=0.44). The PNF rate was significantly higher in moderate group (P=0.003) and severe group (P <0.001) compared with that in no steatosis group. The same results were seen in early graft dysfunction rate. However, graft survival rate and patient survival rate did not differ between groups. Conclusions. Livers with mild steatosis, even with moderate or severe steatosis, could be suitable donor under strict control of transplant conditions.

scholarly journals Prognostic role of levels of extracellular histones H3 for diagnosis of early dysfunction of transplant after hepatic transplantation

2021 ◽  
Vol 88 (3-4) ◽  
pp. 69-75
Author(s):  
N. G. Novruzov
Keyword(s):  
Liver Transplantation ◽  
Total Bilirubin ◽  
Histone H3 ◽  
Graft Dysfunction ◽  
Prognostic Role ◽  
Total Histone ◽  
Extracellular Histones ◽  
Early Graft ◽  
Early Graft Dysfunction

Objective. The aim of this study was to determine the prognostic role of extracellular histones in the diagnosis of early graft dysfunction after liver transplantation.. Materials and methods. The 93 recipients undergoing LDLT were enrolled in this prospective study. Blood samples of patients were collected on postoperative day 1 and histone levels in the plasma samples were measured with Total Histone H3 sandwich ELISA kits. 19 (20.4%) subjects had early graft dysfunction (EAD) which was diagnosed on postoperative day 7 according to Ol-thoff’s criteria, based on liver function tests and coagulation profiles. Other 74 (79.6%) recipients did not have EGD. Results. Levels of circulating histones were depressed in patients with EGD (0,808±0.026, 95% (CI) 0.752-0.864) than in patients without EGD (0.820±0.017, 95% (CI) 0.786-0.854) (P=0.727). These differences were not significant. The sources of histones in the circulation are not etiologies specific and levels of total histone H 3 after 24 h of operation had not stronger predictive value with AUC 0.477 (95 % CI 0.329 to 0.625) for liver dysfunction. The AUC value of the total bilirubin (AUC 0.685, 95 % CI 0.546 to 0.825) in predicting early graft dysfunction outperformed other LFTs and was less than CRP (AUC 0.705, CI 0.573 to 0.838). The optimal cutoff value of total bilirubin obtained from the analysis of ROC curves was 4,5 and surpassed all other parameters with a sensitivity of 94.4% and a specificity of 40.7% respectively for prognoses of EGD (P=0.012). The univariate analysis determined that postoperative neutrophils level and CRP were identified as independent risk factors for early graft dysfunction. Neutrophils had a higher predictive value for liver dysfunction than any other parameter within 24 h (Odds ratio (OR) 16.3; 95% CI: 1.7-156.3, P = 0.016).   Conclusion. Collectively, extracellular histone H3 levels were depressed, total bilirubin and CRP levels were elevated in patients with EGD, which can be used as early predictors for liver tissue damage and early allograft dysfunction in patients after liver transplantation.

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