The Impact of Interleukin 12B (1188A>C), Interleukin 16 (-295T>C), and Interleukin 18 (607C>A, 137G>C) Gene Polymorphisms on Long-Term Renal Transplant Function and Recipient Outcomes

2014 ◽  
Vol 46 (6) ◽  
pp. 2079-2082 ◽  
Author(s):  
J. Pawlus ◽  
A. Sierocka ◽  
K. Tejchman ◽  
Z. Ziętek ◽  
M. Romanowski ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Gene Polymorphisms ◽  
Interleukin 18 ◽  
Transplant Function ◽  
Interleukin 12B ◽  
The Impact

scholarly journals Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival

2020 ◽  
Author(s):  
Julio Chevarria ◽  
Donal J Sexton ◽  
Susan L Murray ◽  
Chaudhry E Adeel ◽  
Patrick O’Kelly ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Graft Failure ◽  
Graft Function ◽  
Renal Transplant Recipients ◽  
Post Transplant ◽  
All Cause Mortality ◽  
Transplant Function ◽  
The Republic ◽  
The Impact

Abstract Background Non-traditional cardiovascular risk factors, including calcium and phosphate derangement, may play a role in mortality in renal transplant. The data regarding this effect are conflicting. Our aim was to assess the impact of calcium and phosphate derangements in the first 90 days post-transplant on allograft and recipient outcomes. Methods We performed a retrospective cohort review of all-adult, first renal transplants in the Republic of Ireland between 1999 and 2015. We divided patients into tertiles based on serum phosphate and calcium levels post-transplant. We assessed their effect on death-censored graft survival and all-cause mortality. We used Stata for statistical analysis and did survival analysis and spline curves to assess the association. Results We included 1525 renal transplant recipients. Of the total, 86.3% had hypophosphataemia and 36.1% hypercalcaemia. Patients in the lowest phosphate tertile were younger, more likely female, had lower weight, more time on dialysis, received a kidney from a younger donor, had less delayed graft function and better transplant function compared with other tertiles. Patients in the highest calcium tertile were younger, more likely male, had higher body mass index, more time on dialysis and better transplant function. Adjusting for differences between groups, we were unable to show any difference in death-censored graft failure [phosphate = 1.14, 95% confidence interval (CI) 0.92–1.41; calcium = 0.98, 95% CI 0.80–1.20] or all-cause mortality (phosphate = 1.10, 95% CI 0.91–1.32; calcium = 0.96, 95% CI 0.81–1.13) based on tertiles of calcium or phosphate in the initial 90 days. Conclusions Hypophosphataemia and hypercalcaemia are common occurrences post-kidney transplant. We have identified different risk factors for these metabolic derangements. The calcium and phosphate levels exhibit no independent association with death-censored graft failure and mortality.

scholarly journals Interleukin-18 Promoter Gene Polymorphisms are not Associated with Myocardial Infarction in Type 2 Diabetes in Slovenia

2011 ◽  
Vol 14 (1) ◽  
pp. 3-9 ◽  
Author(s):  
S Kariž ◽  
D Petrovič
Keyword(s):  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Serum Levels ◽  
Control Group ◽  
Interleukin 18 ◽  
Significant Difference ◽  
Promoter Gene ◽  
The Impact

Interleukin-18 Promoter Gene Polymorphisms are not Associated with Myocardial Infarction in Type 2 Diabetes in SloveniaType 2 diabetes is a major risk factor for myocardial infarction (MI) and chronic inflammation may play a central role in both diseases. Interleukin (IL)-18 is a potent proinflammatory cytokine, which is considered important in acute coronary syndromes and type 2 diabetes. We investigated the association of the -137 (G>C), polymorphism (rs187238) and the -607 (C<A) polymorphism (rs1946518) of the IL-18 gene promoter region in 495 Caucasians with type 2 diabetes, of whom 169 had MI and 326 subjects had no clinically evident coronary artery disease (controls). We also investigated the impact of these polymorphisms on the serum IL-18 level in subsets of both groups and in a normal group. Genotype distributions of the polymorphisms showed no significant difference between cases and controls. However, IL-18 serum levels were significantly lower in diabetics with the137 CC genotype than in those with other genotypes (241.5 ± 132.7 ng/Lvs.340.2 ± 167.4 ng/L; p <0.05). High sensitivity C-reactive protein and IL-18 serum levels were higher in diabetics in the MI group than in the control group. We conclude that these IL-18 promoter gene polymorphisms are not risk factors for MI in Caucasians with type 2 diabetes.

scholarly journals The Impact of Different Induction Immunosuppressive Therapy on Long-Term Kidney Transplant Function When Measured by Iothalamate Clearance

2020 ◽  
Vol 12 (12) ◽  
pp. 787-793
Author(s):  
Tambi Jarmi ◽  
Samir Khouzam ◽  
Nitika Shekhar ◽  
Meray Hosni ◽  
Launia White ◽  
...  
Keyword(s):  
Immunosuppressive Therapy ◽  
Kidney Transplant ◽  
Transplant Function ◽  
The Impact ◽  
Iothalamate Clearance

THE IMPACT OF HYPERLIPIDEMIA ON THE LONG-TERM OUTCOME OF RENAL TRANSPLANT RECIPIENTS.

1999 ◽  
Vol 67 (7) ◽  
pp. S170
Author(s):  
Kazunari Tanabe ◽  
Tadahiko Tokumoto ◽  
Masahiko Harano ◽  
Masashi Inui ◽  
Kouichi Suzuki ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Term Outcome ◽  
Long Term Outcome ◽  
The Impact

115-P: Thymoglobulin induction therapy: Depletion level of CD2/CD3 cells as a predictor of long term renal transplant function

2009 ◽  
Vol 70 ◽  
pp. S69
Author(s):  
Robert E. Cirocco ◽  
Predip Chakabarti ◽  
Margorie Williams ◽  
Tricia Kimble ◽  
Michael Moritz
Keyword(s):  
Renal Transplant ◽  
Induction Therapy ◽  
Transplant Function
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