Fungal Infection by Mucorales Order in Lung Transplantation: 4 Case Reports

2014 ◽  
Vol 46 (6) ◽  
pp. 1849-1851 ◽  
Author(s):  
F.M.F.D. Neto ◽  
P.C.L.B. Camargo ◽  
A.N. Costa ◽  
R.H.O.B. Teixeira ◽  
R.M. Carraro ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Fungal Infection ◽  
Case Reports

scholarly journals Risk and outcomes of pulmonary fungal infection after pediatric lung transplantation

2017 ◽  
Vol 31 (11) ◽  
pp. e13100 ◽  
Author(s):  
Evan Ammerman ◽  
Stuart C. Sweet ◽  
Matthew Fenchel ◽  
Gregory A. Storch ◽  
Carol Conrad ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Fungal Infection

Imaging Findings for Identifying and Evaluating Complications after Lung Transplantation in Patients with Advanced COVID-19: Two Case Reports

2021 ◽  
Vol 17 ◽  
Author(s):  
Junhan Pan ◽  
Manhua Zhu ◽  
Weili Han ◽  
Feng Chen
Keyword(s):  
Lung Transplantation ◽  
Case Reports ◽  
Empiric Antibiotic Therapy ◽  
High Dose ◽  
Imaging Features ◽  
Operative Complications ◽  
Donor Lung ◽  
Lung Transplant Complications ◽  
End Stage ◽  
Post Operative Complications

Background: Lung transplantation might be a viable alternative for patients with irreversible lung injury secondary to coronavirus disease 2019 (COVID-19). Here, we describe two patients with end-stage COVID-19 that received lung transplantations, the clinical-radiologic manifestations of post-operative complications, and the imaging features of allograft rejection. Case presentation: Case 1, a 66-year-old woman presented severe hypoxia after lung transplantation. Chest imaging revealed diffuse homogeneous infiltration in the donor lung. Dramatic resolution of the imaging abnormalities after intravenous administration of methylprednisolone favored a diagnosis of hyperacute rejection. The second is a 70-year-old man, who was infected with bacterial postoperatively. During the empiric antibiotic therapy, chest CT showed newly developed ground glass opacities with septal thickening, suggesting a diagnosis of acute rejection. High-dose corticosteroids therapy was initiated, and the patient recovered gradually. Conclusion: This is the first report describing post-operative complications of lung transplantation in patients with advanced COVID-19. We presumed that imaging procedures could be a useful tool in early detecting lung transplant complications and selecting specific interventions for patients with COVID-19.

Necrotizing Choroiditis-Retinitis as Presenting Symptom of Disseminated Aspergillosis after Lung Transplantation

1997 ◽  
Vol 7 (3) ◽  
pp. 294-296 ◽  
Author(s):  
I. Anteby ◽  
M. Kramer ◽  
G. Rahav ◽  
D. Benezra
Keyword(s):  
Lung Transplantation ◽  
Fungal Infection ◽  
Aspergillus Fumigatus ◽  
Endogenous Endophthalmitis ◽  
Ocular Involvement ◽  
Blurred Vision ◽  
Systemic Manifestations ◽  
Lung Transplants ◽  
Disseminated Aspergillosis ◽  
Aspergillus Endophthalmitis

Background. Endogenous endophthalmitis due to Aspergillus is rare affecting the severely immunosuppressed population, in particular recipients of heart and lung transplants. Ocular involvement of aspergillosis has always been observed late in the course of the disease. Subject. A young woman noted blurred vision in one eye three weeks after lung transplantation. At this stage, no systemic manifestations of fungal infection were detected and the ocular findings were attributed to viral infection. Results. Twenty-four hours after the original ocular complaint, an aggressive endophthalmitis developed in the left eye. The possibility of fungal endophthalmitis was raised. Within 48 hours of her first ocular complaint the patient died. Cultures from a vitreous tap and from autopsy ocular specimens were positive for Aspergillus fumigatus. Conclusions. Aspergillus endophthalmitis may occur in patients undergoing lung transplantation despite antifungal therapy. Increased awareness of this unusual entity may be life and vision saving in these patients.

scholarly journals Two Case Reports of Successful Withdrawal of Mycofenolate Mofetil After Living Donor Lobar Lung Transplantation

2013 ◽  
Vol 45 (1) ◽  
pp. 356-359 ◽  
Author(s):  
T. Miyazaki ◽  
T. Tagawa ◽  
N. Yamasaki ◽  
T. Tsuchiya ◽  
K. Matsumoto ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Living Donor ◽  
Case Reports

scholarly journals Mucormycosis coinfection associated with global COVID-19: a case series from India

2021 ◽  
Vol 7 (5) ◽  
pp. 815
Author(s):  
Deepthi Satish ◽  
Divya Joy ◽  
Anita Ross ◽  
Balasubramanya .
Keyword(s):  
Fungal Infection ◽  
Fungal Infections ◽  
Case Reports ◽  
Case Series ◽  
Retrospective Case ◽  
High Dependency ◽  
Life Threatening ◽  
Immunocompromised Status ◽  
Retrospective Case Study

<p><strong> </strong></p><p class="abstract"><strong>Background: </strong>Mucormycosis is a life-threatening fungal infection that occurs in immunocompromised patients. There has been increasing number of mucormycosis cases during COVID-19 pandemic and also as post COVID-19 sequelae. Our study aimed at scrutinizing a possible coinfection of invasive mycoses and COVID-19 and also its management</p><p class="abstract"><strong>Methods: </strong>We did a retrospective case study of 25 patients presenting as invasive fungal infection from March -December 2020. Majority of patients were immunocompromised, since they presented during the pandemic, all patients were subjected to rapid antigen and RT -PCR testing for COVID-19.</p><p class="abstract"><strong>Results: </strong>11 patients tested COVID-19 positive out of 25. Diagnosis of mucormycosis was based on clinical features, culture, and histopathology from sinus biopsy. COVID-19 positive patients were managed in the high dependency units and COVID-19 wards. Severe COVID-19 positive patients were empirically started on IV Amphotericin based on clinical suspicion of mucormycosis and were taken up for debridement once stable. Negative patients underwent surgical debridement and were started on IV Amphotericin postoperatively.</p><p class="abstract"><strong>Conclusions: </strong>There have been lot of case reports from India showing COVID-19 recovered patients presenting with invasive fungal infections, this could be because of their immunocompromised status and long-term corticosteroid use. In our case series we had three patients with post COVID-19 mucormycosis. There was a surge in COVID-19 positive mucor cases during August and September which also coincided with the maximum peak of cases in India, thereafter, there has been a declining trend. There have been significant challenges in treatment modality and outcome due to the pandemic.</p>

scholarly journals Trichosporon species isolated from scald burn wound in an immunocompetent adult: a case report from Southern Assam

2021 ◽  
Vol 9 (12) ◽  
pp. 3700
Author(s):  
Barnamoy Bhattacharjee ◽  
Debadatta D. Chanda ◽  
Atanu Chakravarty
Keyword(s):  
Fungal Infection ◽  
Bacterial Infections ◽  
Case Reports ◽  
Tertiary Care ◽  
Fungal Colonization ◽  
Trauma Patients ◽  
Sensitivity Testing ◽  
Industrial Worker ◽  
Burn Wounds ◽  
Trichosporon Species

There are quite a good number of case reports on fungal infection in burn wounds in addition to the conventionally notorious bacterial infections in immune-compromised burn trauma patients leading to protracted course of morbidity and higher chances of mortality due to delay in diagnosis. The incidence of fungal infection in burn patients has been increasing with paradigm shift of causal fungus over last 2 decades from Candida albicans and molds to non-albicans Candida, Trichosporon species and other yeast like fungus. But there are rarely few cases of invasive Trichosporon infection in scald burn wounds in immunocompetent individuals. We therefore report a case of Trichosporon species isolation from a scald burn ulcer of an immunocompetent young male industrial worker in 2nd week of its clinical course which responded to oral fluconazole followed by skin grafting since this case scenario in itself is an uncommonly presented and reported event coupled with finding of first ever case with such presentation in this tertiary care institute of Southern Assam. This case is also reported with intention of raising awareness in surgeons for keeping vigil on non-healing burn wounds with empirical antibiotics and about the need of timely pus culture and sensitivity testing to rule out fungal colonization and prevent mortality due to disseminated fungal infection.

Zygomycosis: A Severe Fungal Infection with Challenging Diagnostic Difficulties: A Case with Cardiac Involvement without Cardiac Symptoms.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 5019-5019
Author(s):  
Maria I.A. Madeira ◽  
Maria C. Favarin ◽  
Leonardo C. Palma ◽  
George M.N. Barros ◽  
Cristina A. Souza ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Case Reports ◽  
Vitreous Hemorrhage ◽  
Immunocompromised Host ◽  
Skin Lesions ◽  
Successful Outcome ◽  
System Disease ◽  
Parietal Lobes ◽  
Cardiac Symptoms ◽  
The Brain

Abstract Background: Zygomycosis is an uncommon, severe, life-threatening fungal infection in the immunocompromised host. The most common clinical presentation is rhinocerebral, primary pulmonary and disseminated disease. Myocardial involvement has been described in several case reports, mostly associated with pulmonary symptoms. Cardiac manifestations may, although, dominate the clinical picture of disseminated mucormycosis. These include myocardial infarction, congestive heart failure, conduction system disease, valvular incompetence and pericarditis. Diagnosis is based on histopathology. Objectives: we describe a 46-year-old man, (refractory follicular lymphoma), submitted to non-myeloablative SCT. Six months after SCT he developed cough, weight loss and skin lesions. Biopsies confirmed the diagnosis of cGVHD, and prednisone and CsA was started on D+180. Day+206 he developed fever and headache, uveitis, vitreous hemorrhage and rapid deterioration of consciousness. The MRI of the brain showed multifocal rounded white matter abnormalities with no gadolinium enhancement over the temporal, frontal and parietal lobes bilaterally as well as the periventricular region. Some lesions showed restriction on the diffusion sequence. The lesions did not show vascular territories distribution. CSF samples were tested for the presence of viral and fungal infection by polymerase chain reaction (PCR). Herpesvirus infections (CMV, HSV1, HSV2, VZV, EBV, HHV-6, HHV-7 and HHV-8 were investigated by a panherpes PCR with two pairs of primers targeting the DNA polymerase region. Polyomavirus (JC and BK) and picornavirus were also investigated. No virus was identified by PCR. Panfungal 18S rDNA directed PCR tested negative in 2 CSF samples taken with one week interval. Without any confirmed diagnosis we treated him with broad spectrum antibiotics and antifungals (initially with amphotericin and afterwards with Voriconazole). On day 212 he developed a cardiac arrhythmia (ventricular bigeminy and premature ventricular beats) promptly reverted by Amiodarone. Echocardiogram showed no alteration. D+214 he had recovered consciousness, but developed uncontrolled seizures and cardiac arrest. At that time electrocardiogram showed left bundle branch block. At autopsy no macroscopic alterations could be found in the brain but in the heart multiple white lesions were seen (fig 1) and in the kidneys. In myocardium, CNS and kidney large, non septate hyphae could be seen. In the brain thrombi occluding vessels could be found. Conclusions: Zygomycosis is increasingly reported in immunosuppressed patients. Diagnosis is difficult unless extensive radiologic examinations and invasive procedures (surgery and biopsy) can be performed. Unfortunately we focused our diagnostic approach to the SNC because the predominant manifestation was neurologic. Zygomycosis remains a highly lethal infection especially in imunossupressed patients unable to discontinue immunosuppressant drugs. Early diagnosis and aggressive treatment are the only possibilities to reach a successful outcome. Figure Figure

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