Acute Cellular Rejection Is Associated With Matrix Metalloproteinase-2 Genotype Chimerism After Orthotopic Liver Transplantation

2013 ◽  
Vol 45 (2) ◽  
pp. 558-563 ◽  
Author(s):  
K.S. Korkmaz ◽  
W.R. ten Hove ◽  
B.-J.F. de Rooij ◽  
B. van Hoek ◽  
J.J. van der Reijden ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Matrix Metalloproteinase ◽  
Orthotopic Liver Transplantation ◽  
Acute Cellular Rejection ◽  
Matrix Metalloproteinase 2 ◽  
Cellular Rejection

Optimizing the Management of Abnormal Liver Function Tests after Orthotopic Liver Transplant: A Systems-Based Analysis of Health Care Utilization

2017 ◽  
Vol 83 (10) ◽  
pp. 1152-1156 ◽  
Author(s):  
Tara A. Russell ◽  
Stephanie A. K. Angarita ◽  
Amy Showen ◽  
Vatche Agopian ◽  
Ronald W. Busuttil ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Viral Hepatitis ◽  
Orthotopic Liver Transplantation ◽  
Liver Function Tests ◽  
Acute Cellular Rejection ◽  
Diagnostic Workup ◽  
Not Otherwise Specified ◽  
Bed Days ◽  
Cellular Rejection

Elevated liver function tests (eLFTs) are a major cause of unplanned readmissions (UR) after orthotopic liver transplantation. Diagnostic workup for eLFTs requires multiple invasive and noninvasive procedures, often done in the inpatient setting to expedite diagnosis, yet consequently resulting in increased costs. In this study, we evaluated eLFT readmissions at a single institution with respect to resource utilization. From 3/2013 to 12/2015, 388 patients underwent orthotopic liver transplantation, resulting in 463 UR totaling 5833 bed days; 87 (18.8%) UR and 929 (15.9%) bed days were for eLFTs. During eLFT-UR all patients underwent repeat laboratory testing, 75 (86.2%) liver ultrasound, 66 (75.8%) liver biopsy, and 17 (19.5%) endoscopic retrograde cholangiopancreatography. Discharge diagnoses were acute cellular rejection (40.2%), transaminitis not otherwise specified (17.2%), biliary complications (16.1%), recurrent hepatitis (11.5%), vascular complications (5.8%), viral hepatitis (5.8%), and steatohepatitis (3.5%). The greatest bed-day utilization was secondary to acute cellular rejection (60.8%) and biliary complications (13.7%). More than 35 per cent of eLFT-UR were due to transaminitis not otherwise specified, steatohepatitis, recurrent or viral hepatitis, none of which necessitate inpatient treatment. In addition, >25 per cent of eLFT-UR bed days were attributed to diagnostic workup. Identifying patients who can undergo expedited outpatient workup and require only outpatient management will result in significantly decreased readmissions, bed days, and hospital costs.

Differentiating Acute Cellular Rejection vs. Biliary Tract Pathology After Orthotopic Liver Transplantation: Is a Non-Invasive Approach Feasible?

2011 ◽  
Vol 140 (5) ◽  
pp. S-962
Author(s):  
Anil B. Seetharam ◽  
John M. Iskander ◽  
Joseph T. Merrill ◽  
Sreenivasa S. Jonnalagadda ◽  
Jeffrey Crippin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Biliary Tract ◽  
Acute Cellular Rejection ◽  
Invasive Approach ◽  
Non Invasive ◽  
Cellular Rejection

Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation

2011 ◽  
Vol 31 (8) ◽  
pp. 1110-1117 ◽  
Author(s):  
W. Rogier Ten Hove ◽  
Kerem S. Korkmaz ◽  
Sanna op den Dries ◽  
Bert-Jan F. de Rooij ◽  
Bart van Hoek ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Matrix Metalloproteinase ◽  
Orthotopic Liver Transplantation ◽  
Matrix Metalloproteinase 2 ◽  
Biliary Strictures

The prediction of acute cellular rejection in orthotopic liver transplantation

1999 ◽  
Vol 5 (6) ◽  
pp. 475-479 ◽  
Author(s):  
Andrew J. Bathgate ◽  
Paula Hynd ◽  
David Sommerville ◽  
Peter C. Hayes
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Acute Cellular Rejection ◽  
Cellular Rejection
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