Right Ventricular Longitudinal Strain and Right Ventricular Stroke Work Index in Patients With Severe Heart Failure: Left Ventricular Assist Device Suitability for Transplant Candidates

2012 ◽  
Vol 44 (7) ◽  
pp. 2013-2015 ◽  
Author(s):  
M. Cameli ◽  
S. Bernazzali ◽  
M. Lisi ◽  
C. Tsioulpas ◽  
M.G. Croccia ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Severe Heart Failure ◽  
Left Ventricular ◽  
Stroke Work ◽  
Ventricular Assist ◽  
Work Index ◽  
Stroke Work Index ◽  
Ventricular Stroke Work Index ◽  
Transplant Candidates ◽  
Right Ventricular Stroke Work

Prognostic Importance of Pulmonary Artery Pulsatility Index and Right Ventricular Stroke Work Index in End-Stage Heart Failure Patients

Cardiology ◽  
2022 ◽  
Author(s):  
Zubeyde Bayram ◽  
Cem Dogan ◽  
Suleyman Cagan Efe ◽  
Ali Karagoz ◽  
Busra Guvendi ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Left Ventricular ◽  
Stroke Work ◽  
Work Index ◽  
J Curve ◽  
Stroke Work Index ◽  
Ventricular Stroke Work Index ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Right Ventricular Stroke Work

Background: Right ventricular (RV) failure is an important cause of morbidity and mortality in patients with left ventricular (LV) end-stage heart failure (ESHF). Pulmonary artery pulsatility index (PAPi) and right ventricular stroke work index (RVSWI) are invasive parameters related to RV function. This study aimed to investigate the prognostic impact of PAPi and RVSWI in these patients. Methods and Results: In this study, 416 patients with ESHF were included. The adverse cardiac event (ACE) was defined as left ventricular assist device (LVAD) implantation, urgent heart transplantation, or cardiac mortality. There were 218 ACE cases and 198 non-ACE cases over a median follow-up of 503.50 days. Patients with ACE had lower PAPi and similar RVSWI compared to those without ACE (3.1±1.9 vs. 3.7±2.3, P=0.003 and 7.3±4.9 vs. 6.9±4.4, P=0.422, respectively). According to the results of multivariate analysis, while PAPi (from 2 to 5.65) was associated with ACE, RVSWI (from 3.62 to 9.75) was not associated with ACE (HR: 0.75, 95% CI (0.55-0.95), P=0.031; HR: 0.79, 95% CI: (0.58-1.09), P=0.081, , respectively). Survival analysis revealed that PAPi ≤2.56 was associated with a higher ACE risk compared to PAPi >2.56 (HR: 1.46, 95% CI: 1.11-1.92, P=0.006). PAPi ≤2.56 could predict ACE with 56.7% sensitivity and 51.3% specificity at one year. Furthermore, the association between RVSWI and ACE was nonlinear (J-curve pattern). Low and high values seem to be associated with higher ACE risk compared to intermediate values. Conclusion: The low PAPi was an independent risk for ACE and it had a linear association with it. However, RVSWI seems to be have a nonlinear association with ACE (J-curve pattern).

scholarly journals High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction

2018 ◽  
Vol 8 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Napatt Kanjanahattakij ◽  
Natee Sirinvaravong ◽  
Francisco Aguilar ◽  
Akanksha Agrawal ◽  
Parasuram Krishnamoorthy ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Linear Regression Analysis ◽  
Stroke Work ◽  
Work Index ◽  
Patients With Heart Failure ◽  
Stroke Work Index ◽  
Ventricular Stroke Work Index ◽  
Right Ventricular Stroke Work

Background: In patients with heart failure with preserved ejection fraction (HFpEF), worse kidney function is associated with worse overall cardiac mechanics. Right ventricular stroke work index (RVSWI) is a parameter of right ventricular function. The aim of our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in patients with HFpEF. Method: This was a single-center cross-sectional study. HFpEF is defined as patients with documented heart failure with ejection fraction > 50% and pulmonary wedge pressure > 15 mm Hg from right heart catheterization. RVSWI (normal value 8–12 g/m/beat/m2) was calculated using the formula: RVSWI = 0.0136 × stroke volume index × (mean pulmonary artery pressure – mean right atrial pressure). Univariate and multivariate linear regression analysis was performed to study the correlation between RVSWI and GFR. Result: Ninety-one patients were included in the study. The patients were predominantly female (n = 64, 70%) and African American (n = 61, 67%). Mean age was 66 ± 12 years. Mean GFR was 59 ± 35 mL/min/1.73 m2. Mean RVSWI was 11 ± 6 g/m/beat/m2. Linear regression analysis showed that there was a significant independent inverse relationship between RVSWI and GFR (unstandardized coefficient = –1.3, p = 0.029). In the subgroup with combined post and precapillary pulmonary hypertension (Cpc-PH) the association remained significant (unstandardized coefficient = –1.74, 95% CI –3.37 to –0.11, p = 0.04). Conclusion: High right ventricular workload indicated by high RVSWI is associated with worse renal function in patients with Cpc-PH. Further prospective studies are needed to better understand this association.

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