Lipocalin-2 Serum Levels Are Increased in Acute Hepatic Failure

2013 ◽  
Vol 45 (1) ◽  
pp. 241-244 ◽  
Author(s):  
G.A. Roth ◽  
S. Nickl ◽  
D. Lebherz-Eichinger ◽  
E.M. Schmidt ◽  
H.J. Ankersmit ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Serum Levels ◽  
Lipocalin 2

Nucleosome Serum Levels in Acute Hepatic Failure and MARS Treatment

2009 ◽  
Vol 41 (10) ◽  
pp. 4207-4210 ◽  
Author(s):  
G.A. Roth ◽  
B.A. Lubsczyk ◽  
J. Pilz ◽  
P. Faybik ◽  
H. Hetz ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Serum Levels

scholarly journals Protective Effect of Danhong Injection on Acute Hepatic Failure Induced by Lipopolysaccharide and D-Galactosamine in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Wang ◽  
Li-Na Gao ◽  
Yuan-Lu Cui ◽  
Heng-Li Jiang
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Interleukin 1 ◽  
Acute Hepatic Failure ◽  
Serum Levels ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Glutathione S Transferase ◽  
Danhong Injection ◽  
Hepatic Lipid Peroxidation

Acute hepatic failure (AHF), which leads to an extremely high mortality rate, has become the focus of attention in clinic. In this study, Danhong injection (DHI) was investigated to evaluate the preventive and protective effect on AHF induced by lipopolysaccharide (LPS) and D-galactosamine (GalN) in mice. For AHF induction, ICR mice were intraperitoneally injected with D-GalN (700 mg/kg) and LPS (20 μg/kg). DHI was administrated twice, at 12 and 1 h, respectively, before D-GalN/LPS injection. After stimulation with D-GalN/LPS for 1 and 6 h, serum and livers were collected for analysis. We found that mice administrated with DHI displayed a higher survival rate, lower serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), glutathione S-transferase (GST), and tumor necrosis factor (TNF)-α. DHI inhibited the elevations of hepatic lipid peroxidation (malondialdehyde), caspase-8 activity, and mRNA expression levels of inflammatory cytokines (interleukin-1βand interleukin-6) increased by D-GalN/LPS in the liver. Furthermore, liver histopathological analysis indicated that the DHI group showed markedly fewer apoptotic (TUNEL positive) cells and less pathological changes than those in the AHF model group. These results provide a novel insight into the pharmacological actions of DHI as a potential candidate for treating AHF.

Applying the Principles of Bridging Therapy at Concomitant Acute Hepatic Failure

2016 ◽  
Vol 0 (3.74) ◽  
pp. 112
Author(s):  
I.A. Kuchinskaya ◽  
M.V. Bondar ◽  
D.B. Areshnikov ◽  
S.S. Shapoval ◽  
R.D. Dobush
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Bridging Therapy

scholarly journals Lipocalin 2 serum levels correlate with age and bone turnover biomarkers in healthy subjects but not in postmenopausal osteoporotic women

Bone Reports ◽  
2021 ◽  
pp. 101059
Author(s):  
Antonio Maurizi ◽  
Marco Ponzetti ◽  
Kaare M. Gautvik ◽  
Sjur Reppe ◽  
Anna Teti ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Lipocalin 2 ◽  
Bone Turnover Biomarkers

scholarly journals Lipocalin-2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women

IUBMB Life ◽  
2017 ◽  
Vol 69 (2) ◽  
pp. 88-97 ◽  
Author(s):  
Nearmeen M. Rashad ◽  
Amal S. El-Shal ◽  
Rasha L. Etewa ◽  
Fady M. Wadea
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Levels ◽  
Lipocalin 2 ◽  
Obese Women ◽  
Early Predictors

scholarly journals Treatment of acute hepatic failure and encephalopathy with extracorporeal ex vivo pig-liver perfusion in the critical care unit

Critical Care ◽  
10.1186/cc560 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P187
Author(s):  
MC DaSilva ◽  
M Gupta ◽  
MJ Holman ◽  
HG Yang ◽  
RL Conter ◽  
...  
Keyword(s):  
Critical Care ◽  
Hepatic Failure ◽  
Critical Care Unit ◽  
Ex Vivo ◽  
Liver Perfusion ◽  
Acute Hepatic Failure ◽  
Pig Liver

Acute Hepatic Failure in Swine: Hepatectomy Versus Vascular Occlusion

2004 ◽  
Vol 17 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Nils R. Frühauf ◽  
Karl J. Oldhafer ◽  
Stephanie Westermann ◽  
Georgios C. Sotiropoulos ◽  
Gernot M. Kaiser
Keyword(s):  
Hepatic Failure ◽  
Vascular Occlusion ◽  
Acute Hepatic Failure

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

Sign in / Sign up

Export Citation Format

Share Document