Protective Role of Nitric Oxide Induced by Ischemic Preconditioning on Cold Ischemic-Reperfusion Injury of Rat Liver Graft

2012 ◽  
Vol 44 (4) ◽  
pp. 948-951 ◽  
Author(s):  
Q. Xue ◽  
Z. Yuan ◽  
Z. Chen ◽  
R. Hao ◽  
C. Liu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemic Preconditioning ◽  
Protective Role ◽  
Liver Graft ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion

scholarly journals Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Mohamed Saleem Thattakudian Sheik Uduman ◽  
Rajitha Bodd Reddy ◽  
Priyanka Punuru ◽  
Gopinath Chakka ◽  
Gauthaman Karunakaran
Keyword(s):  
Nitric Oxide ◽  
Reperfusion Injury ◽  
Protective Role ◽  
Global Ischemia ◽  
Protective Mechanism ◽  
Myocardial Tissue ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion ◽  
Transmission Electron

The present study was designed to investigate the role of combined administration of Ramipril and Candesartan againstin vitromyocardial ischemic reperfusion injury in rat. Male Wistar albino rats were divided into five groups (n=6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow). Combination of Ramipril and Candesartan when compared to the monotherapy significantly increased the levels of superoxide dismutase, reduced glutathione, catalase, and nitric oxide and decreased the levels of thiobarbituric acid reactive substances. In addition, the superior protective role of combination of Ramipril and Candesartan on ischemia induced myocardial damage was further confirmed by well preserved myocardial tissue architecture in light microscopy and transmission electron microscopy analysis studies. The combination was proved to be effective in salvaging the myocardial tissue against ischemic reperfusion injury when compared to the monotherapy of individual drugs and further investigations on protective mechanism of drugs by increasing the nitric oxide level at molecular levels are needed.

Protective role of PEG conjugated phospholipid in reducing ischemic reperfusion injury in two allogeneic pig kidney transplant models

Immunobiology ◽  
2016 ◽  
Vol 221 (10) ◽  
pp. 1184
Author(s):  
Kristina N. Ekdahl ◽  
Yuji Teramura ◽  
Sana Asif ◽  
Elin Manell ◽  
Alireza Biglarnia ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Kidney Transplant ◽  
Protective Role ◽  
Ischemic Reperfusion Injury ◽  
Pig Kidney ◽  
Ischemic Reperfusion

Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury

2010 ◽  
Vol 1 (3) ◽  
pp. 278-283 ◽  
Author(s):  
Hannah Rachel Vasanthi ◽  
Subhendu Mukherjee ◽  
Diptarka Ray ◽  
Karuppiah Shanmugasundara Pandian Jayachandran ◽  
Istvan Lekli ◽  
...  
Keyword(s):  
Protein Expression ◽  
Reperfusion Injury ◽  
Ventricular Function ◽  
Protective Role ◽  
Ischemic Reperfusion Injury ◽  
Antiapoptotic Protein ◽  
Ischemic Reperfusion ◽  
Dioscorea Bulbifera

Cardioprotective activity of tubers ofDioscorea bulbiferais mediated by inhibition of cardiomyocyte necrosis and apoptosis as evidenced by the ventricular function and the pro and antiapoptotic protein expression.

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