Plasma C-Reactive Protein Levels Correlate With Markers of Airway Inflammation After Lung Transplantation: A Role for Systemic Inflammation in Bronchiolitis Obliterans Syndrome?

2009 ◽  
Vol 41 (2) ◽  
pp. 595-598 ◽  
Author(s):  
R. Vos ◽  
B.M. Vanaudenaerde ◽  
S.I. De Vleeschauwer ◽  
D.E. Van Raemdonck ◽  
L.J. Dupont ◽  
...  
2009 ◽  
Vol 28 (8) ◽  
pp. 799-807 ◽  
Author(s):  
Robin Vos ◽  
Bart M. Vanaudenaerde ◽  
Stéphanie I. De Vleeschauwer ◽  
Anna Willems-Widyastuti ◽  
Hans Scheers ◽  
...  

2009 ◽  
Vol 28 (2) ◽  
pp. S108
Author(s):  
R. Vos ◽  
B.M. Vanaudenaerde ◽  
S.I. De Vleeschauwer ◽  
L.J. Dupont ◽  
D. Van Raemdonck ◽  
...  

2021 ◽  
Vol 35 ◽  
pp. 205873842110368
Author(s):  
Roberto Aquilani ◽  
Ginetto C Zuccarelli ◽  
Roberto Maestri ◽  
Mirella Boselli ◽  
Maurizia Dossena ◽  
...  

Background Persistent systemic inflammation leads to multidistrectual body dysfunctions. Attenuation of inflammation may improve patients’ functional and life prognoses. We hypothesized that essential amino acids (EAAs) given to elderly patients in rehabilitation after acute diseases may be associated with a reduced inflammatory state. Therefore, this retrospective study investigated whether the supplementation of EAAs – modulators of immune competence – was associated with a reduced inflammation rate in elderly patients. Methods The medical records of 282 patients admitted to the rehabilitation (rehab) institute after acute index events (surgery or medical diseases) (age: 81.18 ± 8.58 years; females: 67.9%) were analyzed. Results 46 patients (16.3% of the entire population) had received EAA supplements (S), whereas the remaining 236 patients had not (N-S). Systemic inflammation (I) (serum C-reactive protein (CRP) > 0.5 mg/dL) was present in 67.4% of the I-S group and 57.2% of the I-N-S group. During rehab, the I-S group (but not the I-N-S group) showed a reduction in CRP levels ( p = 0.03) and an increase in circulating lymphocytes ( p = 0.035), immune cells of the adaptive immune system. C-reactive protein levels remained virtually unchanged in non-inflamed patients who received supplements but increased in non-inflamed patients who did not receive supplements ( p = 0.05). Stratified for developed infections, CRP levels reduced in S patients ( p = 0.008) but did not in N-S patients. Conclusion EAA supplementation was associated with reduced inflammation in both inflamed and infected patients. In addition, EAA supplementation was associated with increased circulating lymphocytes in inflamed patients.


2011 ◽  
Vol 218 (2) ◽  
pp. 511-516 ◽  
Author(s):  
Joanne K. Ujcic-Voortman ◽  
Caroline A. Baan ◽  
Arnoud P. Verhoeff ◽  
Anneke Krol ◽  
Jacob C. Seidell

2009 ◽  
Vol 41 (8) ◽  
pp. 3409-3413 ◽  
Author(s):  
R. Vos ◽  
B.M. Vanaudenaerde ◽  
S.I. De Vleeschauwer ◽  
A. Willems-Widyastuti ◽  
L.J. Dupont ◽  
...  

VASA ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 0187-0194 ◽  
Author(s):  
Xiaoni Chang ◽  
Jun Feng ◽  
Litao Ruan ◽  
Jing Shang ◽  
Yanqiu Yang ◽  
...  

Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement determined by contrast-enhanced ultrasound. Patients and methods: Contrast-enhanced ultrasound was performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast enhancement within the plaque was categorized as grade 1, 2 or 3. Maximum plaque thickness was measured in short-axis view. Carotid artery stenosis was categorized as mild, moderate or severe. Results: Plaque contrast enhancement was not associated with the degree of artery stenosis or with plaque thickness. Serum C-reactive protein levels were positively correlated with the number of new vessels in the plaque. C-reactive protein levels increased in the three groups(Grade 1: 3.72±1.79mg/L; Grade 2: 7.88±4.24 mg/L; Grade 3: 11.02±3.52 mg/L), with significant differences among them (F=10.14, P<0.01), and significant differences between each two groups (P<0.05). Spearman’s rank correlation analysis showed that serum C-reactive protein levels were positively correlated with the degree of carotid plaque enhancement (Rs =0.69, P<0.01). Conclusions: The combination of C-reactive protein levels and intraplaque neovascularization detected by contrast-enhanced ultrasound may allow more accurate evaluation of plaque stability.


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