Glycolipid Studies in Small Intestine and Pancreas of α1,3-Galactosyltransferase Knockout Miniature Swine: α1,3GALT-KO Animals Lack αGAL Antigens and Contain Novel Blood Group H Compounds

2008 ◽  
Vol 40 (2) ◽  
pp. 543-546 ◽  
Author(s):  
M. Diswall ◽  
J. Ångström ◽  
H.-J. Schuurman ◽  
F.J.M.F. Dor ◽  
L. Rydberg ◽  
...  
Keyword(s):  
Small Intestine ◽  
Blood Group ◽  
Miniature Swine ◽  
Blood Group H

Chemical characterization of a blood group H type pentaglycosylceramide of human small intestine

1983 ◽  
Vol 33 (2) ◽  
pp. 135-144 ◽  
Author(s):  
Michael E. Breimer ◽  
Karl-Anders Karlsson ◽  
Göran Larson ◽  
John M. McKibbin
Keyword(s):  
Small Intestine ◽  
Blood Group ◽  
Chemical Characterization ◽  
Human Small Intestine ◽  
Blood Group H

scholarly journals Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucα1-2 glycosyltransferase

2002 ◽  
Vol 367 (3) ◽  
pp. 609-616 ◽  
Author(s):  
Kristina A. THOMSSON ◽  
Marina HINOJOSA-KURTZBERG ◽  
Karin A. AXELSSON ◽  
Steven E. DOMINO ◽  
John B. LOWE ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Small Intestine ◽  
Blood Group ◽  
Northern Blot Analysis ◽  
Fold Increase ◽  
Transmembrane Conductance Regulator ◽  
Wild Type ◽  
Transmembrane Conductance ◽  
Cf Transmembrane Conductance Regulator ◽  
Blood Group H

In gene-targeted mouse models for cystic fibrosis (CF), the disease is mainly manifested by mucus obstruction in the intestine. To explore the mucus composition, mucins insoluble and soluble in 6M guanidinium chloride were purified by three rounds of isopycnic ultracentrifugation from the small and large intestines of CF mice (Cftrm1UNC/Cftrm1UNC) and compared with wild-type mice. The amino acid composition was typical of that for mucins and showed increased amounts of the insoluble (2.5-fold increase) and soluble (7-fold increase) mucins in the small intestine of the CF mice compared with wild-type mice. Mucins from the large intestine of both wild-type and CF mice showed a high but constant level of fucosylation. In contrast, the insoluble and soluble mucins of the small intestine in CF mice revealed a large increase in fucose, whereas those of wild-type mice contained only small amounts of fucose. This increased fucosylation was analysed by releasing the O-linked oligosaccharides followed by GC-MS. NMR spectroscopy revealed that the increased fucosylation was due to an increased expression of blood group H epitopes (Fucα1-2Gal-). Northern-blot analysis, using a probe for the murine Fucα1-2 fucosyltransferase (Fut2), showed an up-regulation of this mRNA in the small intestine of the CF mice, suggesting that this enzyme is responsible for the observed increase in blood group H-type glycosylation. The reason for this up-regulation could be a direct or indirect effect of a non-functional CF transmembrane conductance regulator (CFTR) caused by the absence of CFTR channel.

Relation of 2-O-methyl-l-fucose to blood group H(0) specificity inTaxus Cuspidata twigs

1956 ◽  
Vol 43 (11) ◽  
pp. 256-257 ◽  
Author(s):  
Georg F. Springer ◽  
Norma Ansell ◽  
Hans W. Ruelius
Keyword(s):  
Blood Group ◽  
Blood Group H

Enzymatic incorporation of fucose into blood group H substance

1966 ◽  
Vol 25 (5) ◽  
pp. 542-548 ◽  
Author(s):  
Arthur P. Grollman ◽  
Donald M. Marcus
Keyword(s):  
Blood Group ◽  
Blood Group H

Heterogeneity of carbohydrate fragments isolated from human blood group H and Lea active glycoproteins by base-borohydride degradation

Biochemistry ◽  
1973 ◽  
Vol 12 (10) ◽  
pp. 1955-1961 ◽  
Author(s):  
Luciana Rovis ◽  
Byron Anderson ◽  
Elvin A. Kabat ◽  
Flavio Gruezo ◽  
Jerry Liao
Keyword(s):  
Blood Group ◽  
Human Blood ◽  
Human Blood Group ◽  
Blood Group H
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