Effects of Losartan and Enalapril on High-Sensitivity C-Reactive Protein and Total Antioxidant in Renal Transplant Recipients With Renin-Angiotensin System Polymorphisms

2008 ◽  
Vol 40 (1) ◽  
pp. 16-21 ◽  
Author(s):  
H. Argani ◽  
A. Ghorbanihaghjo ◽  
M. Aghaeishahsavari ◽  
M. Noroozianavval ◽  
N. Rashtchizadeh ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renin Angiotensin System ◽  
High Sensitivity ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
C Reactive Protein ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Reactive Protein ◽  
Total Antioxidant

scholarly journals An Increase in Myeloid-Related Protein Serum Levels Precedes Acute Renal Allograft Rejection

2001 ◽  
Vol 12 (9) ◽  
pp. 1947-1957
Author(s):  
KLAUS BURKHARDT ◽  
MARTIN RADESPIEL-TRÖGER ◽  
HARALD D. RUPPRECHT ◽  
MARGARETE GOPPELT-STRUEBE ◽  
REGINE RIESS ◽  
...  
Keyword(s):  
Pilot Study ◽  
Renal Transplant ◽  
Acute Rejection ◽  
High Sensitivity ◽  
Serum Levels ◽  
Renal Transplant Recipients ◽  
Related Protein ◽  
Transplant Recipients ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract. Upon interaction with activated endothelium, monocytes and neutrophils form complexes of myeloid-related protein 8 (MRP8) (S100A8) and MRP14 (S100A9), two members of the calcium-binding S100 family that are secreted during transendothelial migration. In a pilot study of 20 renal transplant recipients and a validation study of 36 renal transplant recipients, MRP8/14 serum levels were measured with an enzyme-linked immunosorbent assay for 28 d, associated with C-reactive protein and creatinine serum levels, and grouped according to biopsy-proven acute rejection. Serum levels of MRP8/14 but not C-reactive protein were significantly increased for several days during the first 2 wk for the acute rejection groups in both studies (P < 0.005, on day 6 after transplantation). As determined by using receiver operating characteristic curves, the optimal cutoff for 100% specificity and high sensitivity (67%) for acute rejection on day 6 after transplantation was calculated to be 4.2 μg/ml for MRP8/14 in the pilot study; this value was confirmed in the validation study. Positive MRP8/14 serum levels preceded acute rejection episodes by a median of 5 d. A 3-d course of intravenous methylprednisolone therapy reduced prerejection MRP8/14 serum levels from 5.7 μg/ml to 3.3 μg/ml (P < 0.05). All MRP8/14 serum levels were below the cutoff during urinary tract infections, delayed graft function, or cytomegalovirus infections, and these values did not differ significantly from control values. It is concluded that the MRP8/14 complex is a very early serum marker suitable for monitoring of acute rejection with high sensitivity and specificity.

scholarly journals Role of the renin-angiotensin system on the renal functional reserve in renal transplant recipients

1993 ◽  
Vol 44 (1) ◽  
pp. 165-172 ◽  
Author(s):  
Eric Rondeau ◽  
Françoise Paillard ◽  
Marie-Noëlle Peraldi ◽  
Isabelle Violet ◽  
Sophie Tasse ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renin Angiotensin System ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Functional Reserve ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Functional Reserve

Enalapril and losartan affect lipid peroxidation in renal transplant recipients with renin–angiotensin system polymorphisms

2007 ◽  
Vol 40 (3-4) ◽  
pp. 194-200 ◽  
Author(s):  
Nadereh Rashtchizadeh ◽  
Mohammad Aghaeishahsavari ◽  
Hassan Argani ◽  
Masood Noroozianavval ◽  
Pegah Veisi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Renal Transplant ◽  
Renin Angiotensin System ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Angiotensin System ◽  
Renin Angiotensin
Sign in / Sign up

Export Citation Format

Share Document