Pharmacological Induction of Heme Oxygenase-1 Inhibits iNOS and Oxidative Stress in Renal Ischemia-Reperfusion Injury

2007 ◽  
Vol 39 (10) ◽  
pp. 2986-2991 ◽  
Author(s):  
G. Li Volti ◽  
V. Sorrenti ◽  
P. Murabito ◽  
F. Galvano ◽  
M. Veroux ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Heme Oxygenase 1 ◽  
Renal Ischemia Reperfusion Injury ◽  
And Oxidative Stress

scholarly journals Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress

2020 ◽  
Vol 52 (2) ◽  
pp. 125-132
Author(s):  
Feng Han ◽  
Meng Dou ◽  
Yuxiang Wang ◽  
Cuixiang Xu ◽  
Yang Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reperfusion Injury ◽  
Cell Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Well Being ◽  
Renal Ischemia ◽  
Cordyceps Sinensis ◽  
Renal Ischemia Reperfusion Injury ◽  
And Oxidative Stress

Abstract Cordycepin (3′-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal ischemia/reperfusion injury (I/R) are still unknown. In the present study, rats were subject to I/R and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal I/R injury. The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury. Mechanistic studies showed that cordycepin significantly regulated inflammation, apoptosis, and oxidative stress. These data provide new insights for investigating the natural product with the nephroprotective effect against I/R, which should be developed as a new therapeutic agent for the treatment of I/R in the future.

603 Myeloid heme oxygenase-1 controls renal ischemia reperfusion injury

2016 ◽  
Vol 15 (3) ◽  
pp. e603
Author(s):  
M. Rossi ◽  
A. Thierry ◽  
N. Preyat ◽  
S. Delbauve ◽  
O. Leo ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Heme Oxygenase 1 ◽  
Renal Ischemia Reperfusion Injury

scholarly journals Prophylactic effect of ethyl pyruvate on renal ischemia/reperfusion injury in rats

2021 ◽  
Vol 8 (4) ◽  
pp. 102-107
Author(s):  
Roger Yau ◽  
Jonathan Bloom ◽  
Jonathan Wagmaister ◽  
Majid Eshghi ◽  
Muhammad Choudhury ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ethyl Pyruvate ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Primary Role ◽  
Renal Ischemia Reperfusion Injury ◽  
And Oxidative Stress

Background: Following our hypothesis that oxidative stress might play a primary role in renal ischemia/reperfusion injury (RIRI), we investigated if ethyl pyruvate (EPy) with potent antioxidant activity might prevent or alleviate RIRI induced in rats. Methods: Sprague-Dawley rats were randomly divided into four groups: (A) Sham, (B) renal ischemia/reperfusion (RIR), (C) RIR with EPy supplement (RIR+EPy), and (D) RIR with Mann supplement (RIR+Mann). Mannitol (Mann), a preoperative agent being clinically used, was tested for comparison with EPy. Rats were subjected to 40-min ischemia, followed by 24-h reperfusion. Either EPy or Mann was given to rats 30 min prior to ischemia and immediately before the reperfusion period. Results: The RIR and RIR+Mann groups showed palpable kidney injuries with the ~5-fold elevated blood urea nitrogen (BUN) and creatinine (Cr) levels, indicating renal dysfunction. However, the kidneys in the RIR+EPy group appeared merely normal (similar to the Sham’s) with the basal BUN/Cr levels, indicating normal renal function. No effects on histology, BUN or Cr were yet seen with Mann. Moreover, specific kidney injury markers were up-regulated and oxidative stress was also ~2.1-fold severer in the RIR group, whereas little changes in those markers and oxidative stress were seen with EPy supplement (RIR+EPy). Conclusions: Although oxidative stress feasibly plays a key role in RIRI, EPy with antioxidant activity is capable of protecting the kidneys from such an assault. Thus, EPy (not Mann) should be considered as an effective perioperative renoprotective agent that could be used clinically.

scholarly journals Propofol attenuation of renal ischemia/reperfusion injury involves heme oxygenase-1

2007 ◽  
Vol 28 (8) ◽  
pp. 1175-1180 ◽  
Author(s):  
Hui-hua WANG ◽  
Hai-yan ZHOU ◽  
Cong-cong CHEN ◽  
Xiu-lai ZHANG ◽  
Gang CHENG
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Heme Oxygenase 1 ◽  
Renal Ischemia Reperfusion Injury
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