Assessment of Glomerular Filtration Rate in Renal Transplant Patients Using Serum Cystatin C

2006 ◽  
Vol 38 (7) ◽  
pp. 2006-2008 ◽  
Author(s):  
H. Xu ◽  
Y. Lu ◽  
D. Teng ◽  
J. Wang ◽  
L. Wang ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Transplant ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Transplant Patients ◽  
Renal Transplant Patients

Is Serum Cystatin C a Sensitive Marker of Glomerular Filtration Rate (GFR)? A Preliminary Study on Renal Transplant Patients

Renal Failure ◽  
1998 ◽  
Vol 20 (2) ◽  
pp. 303-309 ◽  
Author(s):  
Mario Plebani ◽  
Roberto Dall' Amico ◽  
Michele Mussap ◽  
Giovanni Montini ◽  
Nicoletta Ruzzante ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Transplant ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Transplant Patients ◽  
Preliminary Study ◽  
Sensitive Marker

Cystatin C as an Endogenous Marker of Glomerular Filtration Rate in Renal Transplant Patients

2003 ◽  
Vol 26 (1) ◽  
pp. 55-60 ◽  
Author(s):  
U. Pöge ◽  
B. Stoschus ◽  
B. Stoffel-Wagner ◽  
T. Gerhardt ◽  
H.U. Klehr ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Transplant ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Transplant Patients ◽  
Renal Transplant Patients

scholarly journals Acute Kidney Injuries in Children with Severe Malaria

2020 ◽  
Vol 20 (4) ◽  
pp. e312-317
Author(s):  
Folake M. Afolayan ◽  
Olanrewaju T. Adedoyin ◽  
Mohammed B. Abdulkadir ◽  
Olayinka R. Ibrahim ◽  
Sikiru A. Biliaminu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Severe Malaria ◽  
Diagnostic Criteria ◽  
Cystatin C ◽  
Filtration Rate ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin

Objectives: Serum creatinine levels are often used to diagnose acute kidney injury (AKI), but may not necessarily accurately reflect changes in glomerular filtration rate (GFR). This study aimed to compare the prevalence of AKI in children with severe malaria using diagnostic criteria based on creatinine values in contrast to cystatin C. Methods: This prospective cross-sectional study was performed between June 2016 and May 2017 at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. A total of 170 children aged 0.5–14 years old with severe malaria were included. Serum cystatin C levels were determined using a particle-enhanced immunoturbidmetric assay method, while creatinine levels were measured using the Jaffe reaction. Renal function assessed using cystatin C-derived estimated GFR (eGFR) was compared to that measured using three sets of criteria based on creatinine values including the Kidney Disease: Improved Global Outcomes (KDIGO) and World Health Organization (WHO) criteria as well as an absolute creatinine cut-off value of >1.5 mg/dL. Results: Mean serum cystatin C and creatinine levels were 1.77 ± 1.37 mg/L and 1.23 ± 1.80 mg/dL, respectively (P = 0.002). According to the KDIGO, WHO and absolute creatinine criteria, the frequency of AKI was 32.4%, 7.6% and 16.5%, respectively. In contrast, the incidence of AKI based on cystatin C-derived eGFR was 51.8%. Overall, the rate of detection of AKI was significantly higher using cystatin C compared to the KDIGO, WHO and absolute creatinine criteria (P = 0.003, <0.001 and <0.001, respectively). Conclusion: Diagnostic criteria for AKI based on creatinine values may not indicate the actual burden of disease in children with severe malaria. Keywords: Biomarkers; Acute Kidney Injury; Renal Failure; Glomerular Filtration Rate; Cystatin C; Creatinine; Malaria; Nigeria.

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