Extrahepatic Metabolism and Renal Effects of Sevoflurane in a Case of Liver Transplantation

2006 ◽  
Vol 38 (5) ◽  
pp. 1463-1466 ◽  
Author(s):  
N. Erdem ◽  
M. Kanbak ◽  
F. Saricaoǧlu ◽  
T. Öcal ◽  
C. Tanyel ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Renal Effects ◽  
Extrahepatic Metabolism

scholarly journals EXTRAHEPATIC METABOLISM OF PROPOFOL IN MAN DURING THE ANHEPATIC PHASE OF ORTHOTOPIC LIVER TRANSPLANTATION †

1992 ◽  
Vol 68 (2) ◽  
pp. 183-186 ◽  
Author(s):  
P. VEROLI ◽  
B. O'KELLY ◽  
F. BERTRAND ◽  
J.H. TROUVIN ◽  
R. FARINOTTI ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Extrahepatic Metabolism ◽  
Anhepatic Phase

Extrahepatic Metabolism of Sevoflurane in Children Undergoing Orthotopic Liver Transplantation

2000 ◽  
Vol 92 (3) ◽  
pp. 683-686 ◽  
Author(s):  
Luc J. Van Obbergh ◽  
Roger K. Verbeeck ◽  
Ives Michel ◽  
Serene Lim ◽  
Francis Veyckemans
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Orthotopic Liver Transplantation ◽  
Fluoride Concentration ◽  
Inorganic Fluoride ◽  
End Stage Liver Disease ◽  
Arterial Blood ◽  
Extrahepatic Metabolism ◽  
Anhepatic Phase ◽  
End Stage

Background Sevoflurane is metabolized by cytochrome P450 and produces inorganic fluoride. The anhepatic phase of liver transplantation provides a useful tool to study the extrahepatic metabolism of drugs. The authors therefore studied the extrahepatic metabolism of sevoflurane by measuring the fluoride production in children receiving sevoflurane solely during the anhepatic phase of orthotopic liver transplantation. Methods Children with end-stage liver disease undergoing orthotopic liver transplantation were studied. Anesthesia was provided with isoflurane, sufentanil, and pancuronium. In one group, isoflurane was replaced by sevoflurane as soon as the liver was removed from the patient and maintained until reperfusion of the new liver. Arterial blood samples were drawn at induction, before removal of the liver, 15 min and 30 min after the beginning of the anhepatic phase, at the unclamping of the new liver, and finally 60 and 120 min after the unclamping. Plasma fluoride concentrations were determined by ion-selective electrode. Results No differences between the two groups (n = 10) regarding age, weight, duration of the anhepatic phase, or basal level of inorganic fluoride were found. The fluoride concentration increased significantly as soon as sevoflurane was introduced; it remained stable in the group receiving isoflurane. The peak fluoride concentration was also significantly higher in the first group (mean +/- SD: 5.5 +/- 0.8 microM (sevoflurane group) versus 1.4 +/- 0.5 microM (isoflurane group) P < 0.05). Conclusions These results demonstrate the existence of an extrahepatic metabolism of sevoflurane at least in children with end-stage liver disease.

Risk factors for mortality on the liver waiting list of cirrhotic patients listed for liver transplantation

2001 ◽  
Vol 120 (5) ◽  
pp. A77-A77
Author(s):  
D DELPHINE ◽  
F AGNESE ◽  
B NADINE ◽  
L OLIVIER ◽  
L HUBERT ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Waiting List ◽  
Cirrhotic Patients

Evolution of hepatitis C virus quasispecies after liver transplantation

2001 ◽  
Vol 120 (5) ◽  
pp. A373-A374
Author(s):  
A LYRA ◽  
X FAN ◽  
S RAMRAKHIANI ◽  
A DIBISCEGLIE
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C
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