Effects of Artificial Liver Support System on Patients With Acute or Chronic Liver Failure

2005 ◽  
Vol 37 (10) ◽  
pp. 4359-4364 ◽  
Author(s):  
W.B. Du ◽  
L.J. Li ◽  
J.R. Huang ◽  
Q. Yang ◽  
X.L. Liu ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support System ◽  
Chronic Liver ◽  
Artificial Liver ◽  
Chronic Liver Failure ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System

scholarly journals Survival Benefits With Artificial Liver Support System for Acute-on-Chronic Liver Failure

Medicine ◽  
2016 ◽  
Vol 95 (3) ◽  
pp. e2506 ◽  
Author(s):  
Yi Shen ◽  
Xu-Lin Wang ◽  
Bin Wang ◽  
Jian-Guo Shao ◽  
Yan-Mei Liu ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support System ◽  
Chronic Liver ◽  
Artificial Liver ◽  
Chronic Liver Failure ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System

scholarly journals A prognostic score for patients with acute-on-chronic liver failure treated with plasma exchange-centered artificial liver support system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lingyao Du ◽  
Yuanji Ma ◽  
Shaoqun Zhou ◽  
Fang Chen ◽  
Yan Xu ◽  
...  
Keyword(s):  
Liver Failure ◽  
Plasma Exchange ◽  
Support System ◽  
Predictive Value ◽  
Artificial Liver ◽  
Chronic Liver Failure ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System

AbstractArtificial liver support system (ALSS) therapy is widely used in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). We aimed to develop a predictive score to identify the subgroups who may benefit from plasma exchange (PE)-centered ALSS therapy. A total of 601 patients were retrospectively enrolled and randomly divided into a derivation cohort of 303 patients and a validation cohort of 298 patients for logistic regression analysis, respectively. Five baseline variables, including liver cirrhosis, total bilirubin, international normalized ratio of prothrombin time, infection and hepatic encephalopathy, were found independently associated with 3-month mortality. A predictive PALS model and the simplified PALS score were developed. The predicative value of PALS score (AUROC = 0.818) to 3-month prognosis was as capable as PALS model (AUROC = 0.839), R score (AUROC = 0.824) and Yue-Meng’ score (AUROC = 0.810) (all p > 0.05), and superior to CART model (AUROC = 0.760) and MELD score (AUROC = 0.765) (all p < 0.05). The PALS score had significant linear correlation with 3-month mortality (R2 = 0.970, p = 0.000). PALS score of 0–2 had both sensitivity and negative predictive value of > 90% for 3-month mortality, while PALS score of 6–9 had both specificity and positive predictive value of > 90%. Patients with PALS score of 3–5 who received 3–5 sessions of ALSS therapy had much lower 3-month mortality than those who received 1–2 sessions (32.8% vs. 59.2%, p < 0.05). The more severe patients with PALS score of 6–9 could still benefit from ≥ 6 sessions of ALSS therapy compared to ≤ 2 sessions (63.6% vs. 97.0%, p < 0.05). The PALS score could predict prognosis reliably and conveniently. It could identify the subgroups who could benefit from PE-centered ALSS therapy, and suggest the reasonable sessions.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000032055. Registered 19th April 2020, http://www.chictr.org.cn/showproj.aspx?proj=52471.

scholarly journals Efficacy of a Larger Version of the Hybrid Artificial Liver Support System Using a Polyurethane Foam/Spheroid Packed-Bed Module in a Warm Ischemic Liver Failure Pig Model for Preclinical Experiments

2003 ◽  
Vol 12 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Yo-Ichi Yamashita ◽  
Mitsuo Shimada ◽  
Eiji Tsujita ◽  
Ken Shirabe ◽  
Hiroyuki Ijima ◽  
...  
Keyword(s):  
Liver Failure ◽  
Polyurethane Foam ◽  
Support System ◽  
Packed Bed ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
Group Serum

We have reported the usefulness of a polyurethane foam packed-bed culture system of hepatocyte spheroids as a hybrid artificial liver support system (PUF-HALSS). The aim of this study was to evaluate in detail the efficacy in serum parameters regarding the liver function of a larger version of the PUF-HALSS containing 2 × 1010 porcine hepatocytes for clinical use in warm ischemic liver failure pigs. Warm ischemic liver failure pigs weighing 25 kg were divided into two groups: (1) a control group (n = 3), in which each pig was attached to a PUF-HALSS without hepatocytes, and (2) a HALSS group (n = 3), in which each pig was attached to a PUF-HALSS. In the HALSS group, the increase of blood ammonia was completely suppressed and blood lactate levels were significantly suppressed. The Fisher's ratio was better maintained, and the increase of total bile acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid was significantly suppressed in the HALSS group. Serum creatinine levels were significantly lower, and blood glucose levels were significantly higher in the HALSS group. Serum levels of tumor necrosis factor- a were not elevated in either group. In conclusion, the larger version of the PUF-HALSS demonstrated many advantages as a liver support system in warm ischemic liver failure pigs.

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