Lambda Light Chain Deposition Disease in a Renal Allograft

2005 ◽  
Vol 37 (10) ◽  
pp. 4289-4292 ◽  
Author(s):  
N.D. Tanenbaum ◽  
D.N. Howell ◽  
J.P. Middleton ◽  
R.F. Spurney
Keyword(s):  
Light Chain ◽  
Renal Allograft ◽  
Lambda Light Chain ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

scholarly journals Lambda light chain deposition disease presenting as sicca syndrome

1997 ◽  
Vol 40 (3) ◽  
pp. 587-588 ◽  
Author(s):  
Mohamed A. Hamidou ◽  
Christelle Gires ◽  
Anne Moreau ◽  
Stéphane Martin ◽  
Françoise Buzelin ◽  
...  
Keyword(s):  
Light Chain ◽  
Sicca Syndrome ◽  
Lambda Light Chain ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

De novo light-chain deposition disease in a cadaver renal allograft

1996 ◽  
Vol 28 (3) ◽  
pp. 461-465 ◽  
Author(s):  
Tevfik Ecder ◽  
Abdelghani Tbakhi ◽  
William E. Braun ◽  
Raymond R. Tubbs ◽  
Jonathan Myles ◽  
...  
Keyword(s):  
Light Chain ◽  
Renal Allograft ◽  
De Novo ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review

2016 ◽  
Vol 25 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Benoit Brilland ◽  
Johnny Sayegh ◽  
Anne Croue ◽  
Frank Bridoux ◽  
Jean-François Subra ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Intrahepatic Cholestasis ◽  
Relevant Literature ◽  
Gamma Glutamyl Transferase ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Uncommon Presentation ◽  
Light Chain Deposition ◽  
Glutamyl Transferase

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature. Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.

Sign in / Sign up

Export Citation Format

Share Document