Does Valganciclovir Hydrochloride (Valcyte) Provide Effective Prophylaxis Against Cytomegalovirus Infection in Liver Transplant Recipients?

2005 ◽  
Vol 37 (7) ◽  
pp. 3182-3186 ◽  
Author(s):  
A. Jain ◽  
M. Orloff ◽  
R. Kashyap ◽  
K. Lansing ◽  
R. Betts ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cytomegalovirus Infection ◽  
Transplant Recipients ◽  
Effective Prophylaxis ◽  
Liver Transplant Recipients

scholarly journals Risk factors predicting Cytomegalovirus infection in post liver transplant recipients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M G Abdelrahman ◽  
H A Mahmoud ◽  
M K Mohsen ◽  
M O Ali ◽  
A M N Mohamed
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Organ Transplantation ◽  
Chronic Rejection ◽  
Cytomegalovirus Infection ◽  
Transplant Recipients ◽  
Cmv Infection ◽  
Donor Liver Transplantation ◽  
Liver Transplant Recipients

Abstract Background Liver transplantation is considered to be the only curative treatment for patients with end stage liver disease. Postoperative infection remains to be one of the most common causes of morbidity and mortality throughout the past years. Cytomegalovirus (CMV) infection although considered to be a weak viral infection that usually passes asymptomatic in immunocompetent patients, however, it is considered one of the most common pathogens causing morbidities and mortality in liver transplant recipients. Multiple studies have been done to assess the risk factors for developing CMV infection. Objective Identification of risk factors predicting Cytomegalovirus infection in liver transplant recipients following transplantation. Methods This retrospective study was conducted on 194 patients and their donors who underwent living donor liver transplantation operation at Ain Shams centre for organ transplantation (ASCOT) at Ain Shams specialized hospital in the period between January 2010 and December 2016 with at least one year follow up period after operation for the recipient group. Results In our study, 194 patients undergoing liver transplantation at Ain shams centre for organ transplantation over seven years from January 2010 to December 2016 have been followed to assess risk factors affecting CMV infection development. Chronic rejection was found to be the most common factor associated with CMV infection followed by Cyclosporin (Neoral) as main postoperative immunosuppressant following liver transplantation. Other factors that were found to carry risk for CMV infection included younger age, advanced MELD score, positive CMV IgM status of the donors and recipients. Conclusion Differentiation of Cytomegalovirus disease from Cytomegalovirus infection isn’t always available as it requires tissue invasive techniques. Multiple risk factors have been attributed to cause Cytomegalovirus infection (viremia) . In our study, rejection (chronic rejection) was the factor that carries highest risk for Cytomegalovirus infection development followed by Cyclosporin .

scholarly journals Who among cytomegalovirus-seropositive liver transplant recipients is at risk for cytomegalovirus infection?

2005 ◽  
Vol 11 (6) ◽  
pp. 700-704 ◽  
Author(s):  
Nina Singh ◽  
Cheryl Wannstedt ◽  
Lois Keyes ◽  
Marilyn M. Wagener ◽  
Thomas V. Cacciarelli
Keyword(s):  
At Risk ◽  
Liver Transplant ◽  
Cytomegalovirus Infection ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Diagnostic Value of Nucleic-Acid-Sequence- Based Amplification for the Detection of Cytomegalovirus Infection in Renal and Liver Transplant Recipients

Intervirology ◽  
1999 ◽  
Vol 42 (5-6) ◽  
pp. 373-381 ◽  
Author(s):  
Valère J. Goossens ◽  
Marinus J. Blok ◽  
Maarten H.L. Christiaans ◽  
Johannes P. van Hooff ◽  
Peter Sillekens ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Liver Transplant ◽  
Cytomegalovirus Infection ◽  
Diagnostic Value ◽  
Nucleic Acid Sequence ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Prophylaxis versus pre-emptive treatment for prevention of cytomegalovirus infection in CMV-seropositive orthotopic liver-transplant recipients

2015 ◽  
Vol 87 (5) ◽  
pp. 836-844 ◽  
Author(s):  
Catherine Mengelle ◽  
Lionel Rostaing ◽  
Hugo Weclawiak ◽  
Cécile Rossignol ◽  
Nassim Kamar ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cytomegalovirus Infection ◽  
Orthotopic Liver Transplant ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Biliary and urinary neopterin concentrations in monitoring liver-allograft recipients

1993 ◽  
Vol 39 (1) ◽  
pp. 45-47 ◽  
Author(s):  
A Hausen ◽  
C Aichberger ◽  
A Königsrainer ◽  
G Weiss ◽  
R Margreiter ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cytomegalovirus Infection ◽  
Infectious Complications ◽  
Transplant Recipients ◽  
Liver Allograft ◽  
Post Transplant ◽  
Bile Fluid ◽  
Urinary Neopterin ◽  
Liver Transplant Recipients

Abstract Biliary neopterin concentrations were measured daily in nine liver-transplant recipients during the early post-transplant period (on average, 25 days). Concentrations increased strongly during rejection episodes and decreased quickly after successful antirejection therapy. Contrary to the changes of urinary neopterin, cytomegalovirus infection and hepatitis were not associated with an increase in biliary neopterin concentrations. Therefore, measurement of neopterin in bile fluid and in urine may aid in distinguishing rejection from infectious complications in liver-allograft recipients.

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