A Prospective, Randomized, Multicenter, Double-Blind Study of Early Corticosteroid Cessation Versus Long-Term Maintenance of Corticosteroid Therapy With Tacrolimus and Mycophenolate Mofetil in Primary Renal Transplant Recipients: One Year Report

2005 ◽  
Vol 37 (2) ◽  
pp. 804-808 ◽  
Author(s):  
E.S. Woodle
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Corticosteroid Therapy ◽  
Double Blind Study ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Double Blind ◽  
One Year ◽  
Term Maintenance

Pentoxifylline Prevents Upregulation of Monocyte Tissue Factor in Renal Transplant Recipients Undergoing Post-graft Complications

2000 ◽  
Vol 84 (11) ◽  
pp. 764-769 ◽  
Author(s):  
Sophie Susen ◽  
Marc Hazzan ◽  
Myriam Labalette ◽  
Christophe Zawadzki ◽  
Jean Dessaint ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Tissue Factor ◽  
Graft Survival ◽  
Double Blind Study ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Double Blind ◽  
Activation Markers ◽  
Tnf Α ◽  
Factor Α

SummaryPentoxifylline (PTX) has been demonstrated to improve graft survival in renal transplant recipients undergoing post graft complications. As activated monocytes are possible initiators of vascular damage through tissue factor (TF) expression, we evaluated the monocyte TF expression and endothelium activation markers in 140 consecutive patients receiving cadaveric kidney grafts, randomized in a double-blind study comparing PTX versus placebo. Monocyte TF expression and plasma von Willebrand factor, tissue plasminogen activator, thrombomodulin and tumor necrosis factor-α (TNF-α) levels were determined before transplantation and each month after. Additional samplings were realized in case of acute rejection. TF and TNF-α expression were significantly modified after graft. In patients with complications, PTX prevented the increase of TF expression at month one, and after rejection episodes. Endothelium activation markers were significantly modified after graft and in patients with complications but PTX had no significant effect on their plasma levels. These results suggest that the protective effect of PTX on graft survival could be related to the prevention of monocyte TF upregulation associated with complications.

scholarly journals Improvement in long-term graft survival in cadaveric renal transplant recipients treated with mycophenolate mofetil

2004 ◽  
Vol 17 (9) ◽  
pp. 525-530
Author(s):  
Marc Hazzan ◽  
Francois Provot ◽  
Francois Glowacki ◽  
Marie Christine Copin ◽  
Didier Roumilhac ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Graft Survival ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cadaveric Renal Transplant

LONG-TERM OUTLOOK FOR RENAL TRANSPLANT RECIPIENTS WITH ONE-YEAR FUNCTION: “DOCTOR, WHAT ARE MY CHANCES?”

1991 ◽  
Vol 51 (1) ◽  
pp. 118-122 ◽  
Author(s):  
R. J. FISCHEL ◽  
W. D. PAYNE ◽  
K. J. GILLINGHAM ◽  
D. L. DUNN ◽  
D. E. R. SUTHERLAND ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
One Year

Double‐blind study of interferon administration in renal transplant recipients

1978 ◽  
Vol 8 (4) ◽  
pp. 255-258 ◽  
Author(s):  
W. WEIMAR ◽  
H. SCHELLEKENS ◽  
L. D. F. LAMEIJER ◽  
N. MASUREL ◽  
V. G. EDY ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Blind Study ◽  
Double Blind Study ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Double Blind
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