scholarly journals The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression

2020 ◽  
Vol 13 (4) ◽  
pp. 100751 ◽  
Author(s):  
Zhenghong Li ◽  
Carrie Sun ◽  
Sijia Tao ◽  
Adeboye O. Osunkoya ◽  
Rebecca S. Arnold ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

scholarly journals Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro

Oncotarget ◽  
2018 ◽  
Vol 9 (27) ◽  
pp. 19100-19114 ◽  
Author(s):  
Helen M. Palethorpe ◽  
Damien A. Leach ◽  
Eleanor F. Need ◽  
Paul A. Drew ◽  
Eric Smith
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cell Survival ◽  
Cancer Cells ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

scholarly journals Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Alicia de las Pozas ◽  
Teresita Reiner ◽  
Virginia De Cesare ◽  
Matthias Trost ◽  
Carlos Perez-Stable
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

Pharmacological inhibition of androgen receptor expression induces cell death in prostate cancer cells

2020 ◽  
Vol 77 (22) ◽  
pp. 4663-4673 ◽  
Author(s):  
In-Sung Song ◽  
Yu Jeong Jeong ◽  
Jueun Kim ◽  
Kyoung-Hwa Seo ◽  
Nam-In Baek ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells ◽  
Pharmacological Inhibition

934 Androgen receptor expression is induced by docetaxel in prostate cancer cells

2012 ◽  
Vol 11 (1) ◽  
pp. e934-e934a
Author(s):  
M.V. Tinzl ◽  
B. Chen ◽  
S. Chen ◽  
P.A. Abrahamsson ◽  
N. Dizeyi
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

scholarly journals Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity

The Prostate ◽  
2007 ◽  
Vol 67 (16) ◽  
pp. 1801-1815 ◽  
Author(s):  
Natalia D. Tararova ◽  
Natalya Narizhneva ◽  
Vadim Krivokrisenko ◽  
Andrei V. Gudkov ◽  
Katerina V. Gurova
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Narrow Range ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells ◽  
Expression And Activity

scholarly journals Heat shock protein 70 inhibitors suppress androgen receptor expression in LNC aP95 prostate cancer cells

2017 ◽  
Vol 108 (9) ◽  
pp. 1820-1827 ◽  
Author(s):  
Kazuaki Kita ◽  
Masayuki Shiota ◽  
Masako Tanaka ◽  
Asuka Otsuka ◽  
Masaki Matsumoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Heat Shock Protein 70 ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

Androgen-dependent regulation of Her-2/neu in prostate cancer cells

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10099-10099
Author(s):  
R. Berger ◽  
D. I. Lin ◽  
M. Nieto ◽  
S. Signoretti ◽  
W. C. Hahn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Prostate Cancer Cells ◽  
In Vivo Experiments ◽  
Her 2

10099 Background: The mechanisms underlying the progression of prostate cancer to androgen independence remain poorly understood. Overexpression of Her-2/neu (c-ErbB2) activates the androgen receptor pathway and confers a survival and growth advantage to prostate cancer cells in an androgen-deficient milieu. Methods: Androgen-sensitive prostate cancer cell line LNCaP was used as a model system in vitro and in vivo. Experiments in mice were undertaken by injecting cells orthotopically into the ventral lobe of the mice prostate. Results: Here, we report that androgen receptor (AR) and Her-2/neu reciprocally regulate each other in LNCaP human prostate cancer cells. Absence of androgens, AR blockade with Casodex (bicalutamide) or suppression of AR with RNAi induced Her-2/neu protein expression and phosphorylation in vitro and in vivo. Similarly, suppression of Her-2-neu expression resulted in AR upregulation. In contrast, upon re-administration of androgens, Her-2/neu mRNA, protein and phosphorylation levels decreased linearly with increasing concentrations of androgens as LNCaP cells re-entered the cell cycle. Conclusions: Thus, induction and activation of Her-2/neu occurs in an androgen-depleted environment or as a result of AR inactivation, promoting androgen-independent survival of prostate cancer cells. No significant financial relationships to disclose.

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