scholarly journals Inactivation of SAG or ROC1 E3 Ligase Inhibits Growth and Survival of Renal Cell Carcinoma Cells: Effect of BIM

2019 ◽  
Vol 12 (6) ◽  
pp. 810-818 ◽  
Author(s):  
Yu Wang ◽  
Mingjia Tan ◽  
Hua Li ◽  
Haomin Li ◽  
Yi Sun
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
E3 Ligase ◽  
Carcinoma Cells ◽  
Growth And Survival

scholarly journals TNF-α Induces Epithelial–Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism

2012 ◽  
Vol 10 (8) ◽  
pp. 1109-1119 ◽  
Author(s):  
Ming-Yi Ho ◽  
Shye-Jye Tang ◽  
Mei-Jen Chuang ◽  
Tai-Lung Cha ◽  
Jing-Yao Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Mesenchymal Transition ◽  
Tnf Α ◽  
Dependent Mechanism

Malignant phenotype of renal cell carcinoma cells is switched by Ukrain administration in vitro

2011 ◽  
Vol 22 (8) ◽  
pp. 749-762 ◽  
Author(s):  
Nicoletta Gagliano ◽  
Letizia Pettinari ◽  
Massimo Aureli ◽  
Carla Martinelli ◽  
Elena Colombo ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cells ◽  
Malignant Phenotype

scholarly journals MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1

2018 ◽  
Vol 26 (3) ◽  
pp. 457-466 ◽  
Author(s):  
Haitao Song ◽  
Yanwei Rao ◽  
Gang Zhang ◽  
Xiangbo Kong
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Bioinformatic Analysis ◽  
Carcinoma Cells ◽  
Luciferase Reporter ◽  
Reporter Assay ◽  
Antitumor Effects ◽  
Potential Therapeutic Target

MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this study, we aimed to investigate the potential function of miR-384 in regulating tumorigenesis in RCC. Here we found that miR-384 was significantly downregulated in RCC tissues and cell lines. Overexpression of miR-384 significantly inhibited the growth and invasion of RCC cells, whereas inhibition of miR-384 had the opposite effects. Bioinformatic analysis and luciferase reporter assay showed that miR-384 directly targeted the 3′-untranslated region of astrocyte elevated gene 1 (AEG-1). Further data showed that miR-384 could negatively regulate the expression of AEG-1 in RCC cells. Importantly, miR-384 expression was inversely correlated with AEG-1 expression in clinical RCC specimens. Moreover, miR-384 regulates the activation of Wnt signaling. Overexpression of AEG-1 significantly reversed the antitumor effects of miR-384. Overall, these findings suggest that miR-384 suppresses the growth and invasion of RCC cells via downregulation of AEG-1, providing a potential therapeutic target for the treatment of RCC.

scholarly journals 979 Zoledronic acid sensitizes renal cell carcinoma cells to radiation by downregulating STAT1

2013 ◽  
Vol 12 (1) ◽  
pp. e979-e980
Author(s):  
T. Kijima ◽  
F. Koga ◽  
Y. Fujii ◽  
S. Yoshida ◽  
M. Tatokoro ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Zoledronic Acid ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cells

scholarly journals Interferon-Gamma-Induced Nitric Oxide Inhibits the Proliferation of Murine Renal Cell Carcinoma Cells

2012 ◽  
Vol 8 (8) ◽  
pp. 1109-1120 ◽  
Author(s):  
David J. Tate Jr. ◽  
John R. Patterson ◽  
Cruz Velasco-Gonzalez ◽  
Emily N. Carroll ◽  
Janie Trinh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Interferon Gamma ◽  
Renal Cell ◽  
Carcinoma Cells

scholarly journals MicroRNA-613 inhibits proliferation and invasion of renal cell carcinoma cells through targeting FZD7

2017 ◽  
Vol 16 (4) ◽  
pp. 4279-4286 ◽  
Author(s):  
Haitao Song ◽  
Yonghao Nan ◽  
Xinsheng Wang ◽  
Gang Zhang ◽  
Shi Zong ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cells ◽  
Proliferation And Invasion
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