scholarly journals Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis

2018 ◽  
Vol 11 (5) ◽  
pp. 1188-1201 ◽  
Author(s):  
Shailesh M. Advani ◽  
Pragati Advani ◽  
Stacia M. DeSantis ◽  
Derek Brown ◽  
Helena M. VonVille ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cpg Island ◽  
Meta Analysis ◽  
Molecular Characteristics ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

scholarly journals Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jiang Liu ◽  
Li Tang ◽  
Jinhua Yi ◽  
Guimei Li ◽  
Youwang Lu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chinese Population ◽  
Cpg Island ◽  
Molecular Characteristics ◽  
Cpg Island Methylator Phenotype ◽  
Chinese Populations ◽  
Molecular Features ◽  
Tumour Location ◽  
Low Incidence ◽  
Methylator Phenotype

Abstract Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chinese population with CRC (n = 401) and analysed associations between CIMP status and clinicopathological and molecular features. Results A total of 41 cases, 310 cases, and 40 cases were classified as CIMP-high, CIMP-low, and CIMP-negative, respectively. We detected a significantly low incidence of BRAF mutation in adenomas (2%) and CRC (0.7%), and a relatively low incidence of KRAS mutation (24.9%) compared with that in other populations. We also detected a relatively low incidence of CIMP-high (10.2%), which was significantly associated with younger age (≤49 years of age), female sex, and proximal tumour location. Conclusions This study revealed unique characteristics of CIMP in a Chinese population with colorectal cancer. Developing specific CIMP markers based on unique populations or ethnic groups will further help to fully elucidate CIMP pathogenesis.

scholarly journals The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status

2010 ◽  
Vol 16 (6) ◽  
pp. 1845-1855 ◽  
Author(s):  
Anna M. Dahlin ◽  
Richard Palmqvist ◽  
Maria L. Henriksson ◽  
Maria Jacobsson ◽  
Vincy Eklöf ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cpg Island ◽  
Cancer Prognosis ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

scholarly journals CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

2006 ◽  
Vol 8 (5) ◽  
pp. 582-588 ◽  
Author(s):  
Shuji Ogino ◽  
Takako Kawasaki ◽  
Gregory J. Kirkner ◽  
Massimo Loda ◽  
Charles S. Fuchs
Keyword(s):  
Colorectal Cancer ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Kras Mutations ◽  
Male Sex ◽  
Methylator Phenotype
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