scholarly journals Validation and Comparison of the Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated By Boron-Rich Liposomes in Multiple Murine Tumor Models

2017 ◽  
Vol 10 (4) ◽  
pp. 686-692 ◽  
Author(s):  
Charles A Maitz ◽  
Aslam A Khan ◽  
Peter J Kueffer ◽  
John D Brockman ◽  
Jonathan Dixson ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Efficacy ◽  
Neutron Capture Therapy ◽  
Tumor Models ◽  
Murine Tumor ◽  
Boron Neutron Capture

Tumor Blood Vessel “Normalization” Improves the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) in Experimental Oral Cancer

2012 ◽  
Vol 177 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Ana J. Molinari ◽  
Emiliano C. C. Pozzi ◽  
Andrea Monti Hughes ◽  
Elisa M. Heber ◽  
Marcela A. Garabalino ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Blood Vessel ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Efficacy ◽  
Neutron Capture Therapy ◽  
Vessel Normalization ◽  
Boron Neutron Capture ◽  
Tumor Blood Vessel

Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies

2018 ◽  
pp. 416-461
Author(s):  
Amanda E. Schwint ◽  
Andrea Monti Hughes ◽  
Marcela A. Garabalino ◽  
Emiliano C.C. Pozzi ◽  
Elisa M. Heber ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Efficacy ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

Biology ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 327
Author(s):  
Amanda E. Schwint ◽  
Andrea Monti Hughes ◽  
Marcela A. Garabalino ◽  
Gustavo A. Santa Cruz ◽  
Sara J. González ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Efficacy ◽  
Tumor Control ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and neck cancer were performed to optimize the therapeutic efficacy of BNCT, contribute towards exploring the role of BNCT in veterinary medicine, put in place technical aspects for an upcoming clinical trial of BNCT for head and neck cancer at the RA-6 Nuclear Reactor, and assess the feasibility of employing the existing B2 beam to treat large, deep-seated tumors. Five dogs with head and neck cancer with no other therapeutic option were treated with two applications of BNCT mediated by boronophenyl-alanine (BPA) separated by 3–5 weeks. Two to three portals per BNCT application were used to achieve a potentially therapeutic dose over the tumor without exceeding normal tissue tolerance. Clinical and Computed Tomography results evidenced partial tumor control in all cases, with slight-moderate mucositis, excellent life quality, and prolongation in the survival time estimated at recruitment. These exploratory studies show the potential value of BNCT in veterinary medicine and contribute towards initiating a clinical BNCT trial for head and neck cancer at the RA-6 clinical facility.

scholarly journals Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model

2014 ◽  
Vol 111 (45) ◽  
pp. 16077-16081 ◽  
Author(s):  
Elisa M. Heber ◽  
M. Frederick Hawthorne ◽  
Peter J. Kueffer ◽  
Marcela A. Garabalino ◽  
Silvia I. Thorp ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Efficacy ◽  
Cheek Pouch ◽  
Neutron Capture Therapy ◽  
Hamster Cheek Pouch ◽  
Boron Neutron Capture

Boron neutron capture therapy (BNCT) for liver metastasis: therapeutic efficacy in an experimental model

2012 ◽  
Vol 51 (3) ◽  
pp. 331-339 ◽  
Author(s):  
Emiliano C. C. Pozzi ◽  
Jorge E. Cardoso ◽  
Lucas L. Colombo ◽  
Silvia Thorp ◽  
Andrea Monti Hughes ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Experimental Model ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Efficacy ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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