scholarly journals MicroRNA-196a and -196b as Potential Biomarkers for the Early Detection of Familial Pancreatic Cancer

2014 ◽  
Vol 7 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Emily P. Slater ◽  
Konstantin Strauch ◽  
Susanne Rospleszcz ◽  
Annette Ramaswamy ◽  
Irene Esposito ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Familial Pancreatic Cancer ◽  
Potential Biomarkers

BRCA2 and predisposition to pancreatic and other cancers

2001 ◽  
Vol 3 (14) ◽  
pp. 1-10 ◽  
Author(s):  
Meghan A. Arnold ◽  
Michael Goggins
Keyword(s):  
Breast Cancer ◽  
Pancreatic Cancer ◽  
Early Detection ◽  
Pancreatic Adenocarcinoma ◽  
Germline Mutations ◽  
Familial Pancreatic Cancer ◽  
Pancreatic Carcinogenesis ◽  
Increased Risk ◽  
Late Event ◽  
Genetic Events

Pancreatic adenocarcinoma is a major cause of cancer deaths in the industrialised world. Recent work has focused on the genetics of pancreatic cancer with a goal of finding an early detection marker that might allow for greater rates of survival than are currently possible. The breast cancer 2 gene (BRCA2) is one of numerous genes implicated in familial pancreatic cancer. Carriers of germline mutations of the BRCA2 gene have an increased risk of several cancers, among them pancreatic adenocarcinoma. During pancreatic carcinogenesis, bi-allelic inactivation of BRCA2 occurs as a late event, suggesting that other genetic events must occur before neoplastic cells can tolerate loss of BRCA2.

scholarly journals LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer

2013 ◽  
Vol 6 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Emily P. Slater ◽  
Volker Fendrich ◽  
Konstantin Strauch ◽  
Susanne Rospleszcz ◽  
Annette Ramaswamy ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Serum Markers ◽  
Familial Pancreatic Cancer

The Spanish national familial pancreatic cancer registry Pan-Gen-FAM: Screening of high-risk individuals for the early detection of a pancreatic tumor

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S87
Author(s):  
Carmen Guillén-Ponce ◽  
Reyes Ferreiro ◽  
Vanessa Pachon ◽  
Julie Earl ◽  
Maria Teresa Salazar Lopez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Risk ◽  
Early Detection ◽  
Cancer Registry ◽  
Pancreatic Tumor ◽  
Familial Pancreatic Cancer

scholarly journals Japanese Familial Pancreatic Cancer Registry with the aim to early detection of pancreatic cancer

Suizo ◽  
2017 ◽  
Vol 32 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Chigusa MORIZANE ◽  
Masayuki KITANO ◽  
Susumu HIJIOKA ◽  
Tetsuhide ITO ◽  
Terumi KAMISAWA ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Cancer Registry ◽  
Familial Pancreatic Cancer

Expert consensus on surveillance methods for early detection of familial pancreatic cancer in Japan

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S39
Author(s):  
Masayuki Kitano ◽  
Chigusa Morizane ◽  
Susumu Hijioka ◽  
Hiroyuki Maguchi ◽  
Hideaki Takahashi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Expert Consensus ◽  
Familial Pancreatic Cancer

scholarly journals Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Maryam A. L. Eissa ◽  
Lane Lerner ◽  
Eihab Abdelfatah ◽  
Nakul Shankar ◽  
Joseph K. Canner ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Promoter Methylation ◽  
Potential Biomarkers

scholarly journals 4287 Extracellular vesicles as biomarkers for early detection of pancreatic cancer

2020 ◽  
Vol 4 (s1) ◽  
pp. 7-7
Author(s):  
Charles P Hinzman ◽  
Shivani Bansal ◽  
Yaoxiang Li ◽  
Partha Banerjee ◽  
Amrita Cheema
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Cell Lines ◽  
Extracellular Vesicles ◽  
Late Stage ◽  
Normal Cell ◽  
Normal Pancreas ◽  
Pancreas Cell ◽  
Potential Biomarkers

OBJECTIVES/GOALS: Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths by 2030. Though many other cancers have seen improvements in patient survival rates, patients diagnosed with PDAC have a 5-year survival rate of only ~9%. A major contributor to decreased survival is late-stage diagnosis of the disease. New methods of early detection are urgently needed. Extracellular vesicles (EVs) are secreted from cells of all tissue types into the circulation. EVs play important roles in a variety of diseases. They have shown to promote cancer progression and they are being studied as potential biomarkers for disease diagnosis. The purpose of this study was to perform qualitative and quantitative characterization of small-molecule profiles of EVs derived from various pancreatic cancer (PC) and normal pancreas cell lines, to provide proof-of-concept for evaluating the efficacy of leveraging EVs as potential biomarkers of PDAC. METHODS/STUDY POPULATION: EVs were isolated from the conditioned media of six PC and two normal pancreas cell lines using differential ultracentrifugation with filtration. EV enrichment was validated using quantitative ELISA, immunoblot and transmission electron microscopy. Targeted liquid chromatography coupled to mass spectrometry (LC-MS/MS) and untargeted (UPLC-QTOF-MS) metabolomics were used to analyze the biochemical composition of EVs. RESULTS/ANTICIPATED RESULTS: The biochemical profile of PC EVs was found to be significantly different from the profiles of normal cell EVs. Interestingly, amino acids were downregulated in PC EVs as compared to normal cell EVs. However, PC EVs were enriched in lactate and malate. PC EVs also had significant upregulation in other small molecules such as xanthosine, guanosine diphosphate and nicotinamide. DISCUSSION/SIGNIFICANCE OF IMPACT: Our results indicate that the biochemical characterization of EVs using metabolomics has the potential to yield biomarkers which can delineate cancer cell-derived EVs from normal cell-derived EVs. Further work will test the clinical significance of these findings by similar analyses of plasma of PDAC patients. Furthermore, these profiles may be detectable before progression of the disease to late-stage PDAC, leading to the development of assays for earlier diagnosis in patients.

Circulating free tumor DNA (cftDNA) as a novel biomarker for the early detection of cancer in familial pancreatic cancer families

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S24
Author(s):  
Julie Earl ◽  
Carmen Guillèn-Ponce ◽  
Reyes Ferreiro ◽  
Vanessa Pachon ◽  
Maria Teresa Salazar Lopez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Early Detection Of Cancer ◽  
Familial Pancreatic Cancer ◽  
Tumor Dna
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