scholarly journals Low Dose Rate Radiosensitization of Hepatocellular Carcinoma In Vitro and in Patients

2014 ◽  
Vol 7 (4) ◽  
pp. 472-478 ◽  
Author(s):  
Kyle C. Cuneo ◽  
Mary A. Davis ◽  
Mary U. Feng ◽  
Paula M. Novelli ◽  
William D. Ensminger ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dose Rate ◽  
Low Dose ◽  
Low Dose Rate

Assessment of supra-additive effects of cytotoxic drugs and low dose rate irradiation in an in vitro model for hepatocellular carcinoma

2006 ◽  
Vol 84 (10) ◽  
pp. 1021-1028 ◽  
Author(s):  
Bieke Lambert ◽  
Leo De Ridder ◽  
Filip De Vos ◽  
Guido Slegers ◽  
Virginie de Gelder ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dose Rate ◽  
In Vitro Model ◽  
Low Dose ◽  
High Dose ◽  
Additive Effects ◽  
Multicellular Spheroids ◽  
Low Dose Rate ◽  
Vitro Model

The use of 5-fluorouracil, topotecan, or gemcitabine was tested for enhancement of the effects of low dose rate (LDR) irradiation in an in vitro model for hepatocellular carcinoma. For comparison, all drugs were tested in combination with high dose rate (HDR) γ-irradiation as well. Multicellular spheroids of HepG2 cells were exposed to HDR or LDR irradiation by means of external beam cobalt-60 or rhenium-188 (188Re), respectively, dissolved in the culture medium. Secondly, exposure to irradiation was combined with the cytotoxic drug. Toxicity was evaluated by means of a quantitative spheroid outgrowth assay and histology. For 5-fluorouracil, supra-additive effects were observed in combination with HDR irradiation. With 188Re, the supra-additive toxicity was only transient. For topotecan and 188Re, no supra-additive effects were seen, whereas the addition of HDR irradiation at the end of the topotecan exposure yielded lasting supra-additive effects. Incubation with gemcitabine followed by exposure to HDR irradiation, induced a synergistic toxicity on the outgrowth. No supra-additive effects were observed when HDR irradiation was added at the start of the incubation with gemcitabine or combined with LDR irradiation. For all drugs tested, supra-additive effects were observed with HDR irradiation if the timing of the irradiation was appropriate. For 188Re, no lasting supra-additive effects were observed.

Activated human N-ras oncogene enhances x-irradiation repair of mammalian cells in vitro less effectively at low dose rate

1985 ◽  
Vol 8 (6) ◽  
pp. 517-522 ◽  
Author(s):  
T. J. FitzGerald ◽  
C. Daugherty ◽  
K. Kase ◽  
L. A. Rothstein ◽  
M. McKenna ◽  
...  
Keyword(s):  
Dose Rate ◽  
Mammalian Cells ◽  
Low Dose ◽  
Ras Oncogene ◽  
Low Dose Rate ◽  
X Irradiation

Effects of a very low dose rate of chronic ionizing radiation on the division potential of human embryonic lung fibroblasts in vitro

1986 ◽  
Vol 21 (1) ◽  
pp. 1-11 ◽  
Author(s):  
F. Croute ◽  
S. Vidal ◽  
J.P. Soleilhavoup ◽  
C. Vincent ◽  
G. Serre ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Low Dose ◽  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung ◽  
Low Dose Rate

scholarly journals In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds

2013 ◽  
Vol 9 (1) ◽  
pp. 25-27 ◽  
Author(s):  
Wilfred Ngwa ◽  
Houari Korideck ◽  
Amin I. Kassis ◽  
Rajiv Kumar ◽  
Srinivas Sridhar ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Gamma Irradiation ◽  
Dose Rate ◽  
Low Dose ◽  
Low Dose Rate
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