scholarly journals Tryptophan Metabolism as a Pharmacological Target

2021 ◽  
Vol 42 (1) ◽  
pp. 60-73
Author(s):  
Morgane Modoux ◽  
Nathalie Rolhion ◽  
Sridhar Mani ◽  
Harry Sokol
Keyword(s):  
Tryptophan Metabolism ◽  
Pharmacological Target

The Renal Outer Medullary Potassium Channel (ROMK): An Intriguing Pharmacological Target for an Innovative Class of Diuretic Drugs

2018 ◽  
Vol 25 (23) ◽  
pp. 2627-2636 ◽  
Author(s):  
Vincenzo Calderone ◽  
Alma Martelli ◽  
Eugenia Piragine ◽  
Valentina Citi ◽  
Lara Testai ◽  
...  
Keyword(s):  
Physiological Role ◽  
Clinical Use ◽  
Diuretic Activity ◽  
First Line ◽  
Potassium Homeostasis ◽  
Diuretic Drugs ◽  
Pharmacological Target ◽  
Diuretic Agents ◽  
Effective Drugs

In the last four decades, the several classes of diuretics, currently available for clinical use, have been the first line option for the therapy of widespread cardiovascular and non-cardiovascular diseases. Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis. <p> In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors. This novel class is expected to promote diuretic activity comparable to (or even higher than) that provided by the most effective drugs used in clinics (such as furosemide), with limited effects on potassium homeostasis. <p> In this review, the physio-pharmacological roles of ROMK channels in the renal function are reported, along with the most representative molecules which have been currently developed as ROMK inhibitors.

HIV-1 Associated Topoisomerase IIβ Kinase: A Potential Pharmacological Target for Viral Replication

2013 ◽  
Vol 19 (26) ◽  
pp. 4776-4786 ◽  
Author(s):  
Kannapiran Ponraj ◽  
Maddela Prabhakar ◽  
R.S. Rathore ◽  
Akhila Bommakanti ◽  
Anand Kondapi
Keyword(s):  
Viral Replication ◽  
Topoisomerase Ii ◽  
Pharmacological Target ◽  
Hiv 1 ◽  
Kinase A

Characterization of Low Right Atrial Isthmus as the Slow Conduction Zone and Pharmacological Target in Typical Atrial Flutter

Circulation ◽  
1997 ◽  
Vol 96 (8) ◽  
pp. 2601-2611 ◽  
Author(s):  
Ching-Tai Tai ◽  
Shih-Ann Chen ◽  
Chern-En Chiang ◽  
Shih-Huang Lee ◽  
Kwo-Chang Ueng ◽  
...  
Keyword(s):  
Atrial Flutter ◽  
Right Atrial ◽  
Slow Conduction ◽  
Typical Atrial Flutter ◽  
Pharmacological Target ◽  
Conduction Zone

Cardiac hERG K+ Channel as Safety and Pharmacological Target

2021 ◽  
Author(s):  
Shi Su ◽  
Jinglei Sun ◽  
Yi Wang ◽  
Yanfang Xu
Keyword(s):  
K Channel ◽  
Pharmacological Target

The HCN channel as a pharmacological target: Why, where, and how to block it

2021 ◽  
Author(s):  
Valentina Balducci ◽  
Caterina Credi ◽  
Leonardo Sacconi ◽  
Maria Novella Romanelli ◽  
Laura Sartiani ◽  
...  
Keyword(s):  
Hcn Channel ◽  
Pharmacological Target
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