How important is protein kinase C in μ-opioid receptor desensitization and morphine tolerance?

2006 ◽  
Vol 27 (11) ◽  
pp. 558-565 ◽  
Author(s):  
Chris P. Bailey ◽  
Forrest L. Smith ◽  
Eamonn Kelly ◽  
William L. Dewey ◽  
Graeme Henderson
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Opioid Receptor ◽  
Morphine Tolerance ◽  
Receptor Desensitization ◽  
Kinase C ◽  
Μ Opioid Receptor

scholarly journals Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

2009 ◽  
Vol 29 (2) ◽  
pp. 307-318 ◽  
Author(s):  
C. P. Bailey ◽  
J. Llorente ◽  
B. H. Gabra ◽  
F. L. Smith ◽  
W. L. Dewey ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Locus Coeruleus ◽  
Opioid Receptor ◽  
Kinase C ◽  
Μ Opioid Receptor

RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling

2007 ◽  
Vol 19 (4) ◽  
pp. 723-730 ◽  
Author(s):  
Seena K. Ajit ◽  
Suneela Ramineni ◽  
Wade Edris ◽  
Rachel A. Hunt ◽  
Wah-Tung Hum ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Receptor Signaling ◽  
Interacting Protein ◽  
Mu Opioid ◽  
Kinase C

Protein kinase C(alpha) actively downregulates through caveolae-dependent traffic to an endosomal compartment

2000 ◽  
Vol 113 (14) ◽  
pp. 2575-2584
Author(s):  
C. Prevostel ◽  
V. Alice ◽  
D. Joubert ◽  
P.J. Parker
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Initial Step ◽  
Receptor Internalization ◽  
Similar Process ◽  
Receptor Desensitization ◽  
Kinase C ◽  
Annexin I ◽  
Pkc Alpha

Receptor desensitization occurs through receptor internalization and targeting to endosomes, a prerequisite for sorting and degradation. Such trafficking processes may not be restricted to membrane associated receptors but may also play an important role in the downregulation of cytoplasmic transducers such as protein kinase C (PKC). It is demonstrated here that acute TPA exposure induces the transport of activated PKC(alpha) from the plasma membrane to endosomes. This process requires PKC activity and catalytically competent PKC can even promote a similar process for a truncated regulatory domain PKC(α) protein. It is established that PKC(α) is targeted to the endosome compartment as an active kinase, where it colocalizes with annexin I, a substrate of PKC. Thus, PKC(alpha) downregulation shares features with plasma membrane associated receptor sorting and degradation. However, it is shown that PKC(α) delivery to the endosome compartment is not a Rab5 mediated process in contrast to the well characterised internalisation of the transferrin receptor. An alternative route for PKC(alpha) is evidenced by the finding that the cholesterol binding drugs nystatin and filipin, known to inhibit caveolae mediated trafficking, are able to block PKC(alpha) traffic and down regulation. Consistent with this, the endosomes where PKC(alpha) is found also contain caveolin. It is concluded that the initial step in desensitisation of PKC(alpha) involves active delivery to endosomes via a caveolae mediated process.

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