A renaissance in trace amines inspired by a novel GPCR family

2005 ◽  
Vol 26 (5) ◽  
pp. 274-281 ◽  
Author(s):  
Lothar Lindemann ◽  
Marius C. Hoener
Keyword(s):  
Trace Amines ◽  
Gpcr Family

scholarly journals Limbic Expression of mRNA Coding for Chemoreceptors in Human Brain—Lessons from Brain Atlases

2021 ◽  
Vol 22 (13) ◽  
pp. 6858
Author(s):  
Fanny Gaudel ◽  
Gaëlle Guiraudie-Capraz ◽  
François Féron
Keyword(s):  
G Proteins ◽  
The Body ◽  
Trace Amines ◽  
Chemical Senses ◽  
Brain Areas ◽  
Genes Encoding ◽  
The Central Nervous System ◽  
Human Brains ◽  
The Brain ◽  
Brain Atlases

Animals strongly rely on chemical senses to uncover the outside world and adjust their behaviour. Chemical signals are perceived by facial sensitive chemosensors that can be clustered into three families, namely the gustatory (TASR), olfactory (OR, TAAR) and pheromonal (VNR, FPR) receptors. Over recent decades, chemoreceptors were identified in non-facial parts of the body, including the brain. In order to map chemoreceptors within the encephalon, we performed a study based on four brain atlases. The transcript expression of selected members of the three chemoreceptor families and their canonical partners was analysed in major areas of healthy and demented human brains. Genes encoding all studied chemoreceptors are transcribed in the central nervous system, particularly in the limbic system. RNA of their canonical transduction partners (G proteins, ion channels) are also observed in all studied brain areas, reinforcing the suggestion that cerebral chemoreceptors are functional. In addition, we noticed that: (i) bitterness-associated receptors display an enriched expression, (ii) the brain is equipped to sense trace amines and pheromonal cues and (iii) chemoreceptor RNA expression varies with age, but not dementia or brain trauma. Extensive studies are now required to further understand how the brain makes sense of endogenous chemicals.

scholarly journals Cerebrospinal fluid monoamine levels in central hypersomnolence disorders

SLEEP ◽  
2021 ◽  
Author(s):  
Lucie Barateau ◽  
Isabelle Jaussent ◽  
Julien Roeser ◽  
Claudio Ciardiello ◽  
Thomas S Kilduff ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Daytime Sleepiness ◽  
Direct Consequence ◽  
Trace Amines ◽  
Idiopathic Hypersomnia ◽  
National Reference Center ◽  
Drug Free ◽  
Sleep Propensity

Abstract Study objectives Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin neurons or whether low orexin reduces the efficacy of the monoaminergic systems to promote wakefulness is unclear. The neurobiology underlying sleepiness in other central hypersomnolence disorders, narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH), is currently unknown. Methods Eleven biogenic amines including the monoaminergic neurotransmitters and their metabolites and five trace amines were measured in the cerebrospinal fluid (CSF) of 94 drug-free subjects evaluated at the French National Reference Center for Narcolepsy: 39 NT1(orexin-deficient) patients, 31 patients with objective sleepiness non-orexin deficient (NT2 and IH), and 24 patients without objective sleepiness. Results Three trace amines were undetectable in the sample: Tryptamine, Octopamine, and 3-iodothyronamine. No significant differences were found among the three groups for quantified monoamines and their metabolites in crude and adjusted models; however, CSF 5-HIAA levels tended to increase in NT1 compared to other patients after adjustment. Most of biomarkers were not associated with ORX-A levels, clinical or neurophysiological parameters, but a few biomarkers (e.g., MHPG and norepinephrine) correlated with daytime sleepiness and high REM sleep propensity. Conclusion We found no striking differences among CSF monoamines, their metabolites and trace amine levels, and few associations between them and key clinical or neurophysiological parameters in NT1,NT2/IH and patients without objective sleepiness. Although mostly negative, these findings are a significant contribution to our understanding of the neurobiology of hypersomnolence in these disorders that remain mysterious and deserve further exploration.

Determination of dopamine, norepinephrine, and related trace amines by prechromatographic derivatization with naphthalene-2,3-dicarboxaldehyde

1989 ◽  
Vol 180 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Takao Kawasaki ◽  
Takeru Higuchi ◽  
Kazuhiro Imai ◽  
Osborne S. Wong
Keyword(s):  
Trace Amines

Encapsulation of monoamine neurotransmitters and trace amines by amphiphilic anionic calix[5]arene micelles

2014 ◽  
Vol 38 (12) ◽  
pp. 5983-5990 ◽  
Author(s):  
Giuseppe Gattuso ◽  
Anna Notti ◽  
Sebastiano Pappalardo ◽  
Melchiorre F. Parisi ◽  
Ilenia Pisagatti ◽  
...  
Keyword(s):  
Trace Amines ◽  
Monoamine Neurotransmitters

Brain Trace Amines

1982 ◽  
pp. 189-222 ◽  
Author(s):  
Alan A. Boulton ◽  
Augusto V. Juorio
Keyword(s):  
Trace Amines

A Contribution to the Neuromodulatory/Neurotransmitter Role of Trace Amines

Trace Amines ◽  
1988 ◽  
pp. 213-221 ◽  
Author(s):  
J. Harris ◽  
S. Trivedi ◽  
B. L. Ramakrishna
Keyword(s):  
Trace Amines

Trace Amines/Metabolite Responses in Stress

1985 ◽  
pp. 395-403 ◽  
Author(s):  
J. Harris ◽  
B. A. Davis ◽  
G. S. Krahenbuhl ◽  
A. A. Boulton
Keyword(s):  
Trace Amines

Tranylcypromine and an N-Cyanoethyl Analogue: Effects on Brain Levels of the Trace Amines β-Phenylethylamine and Tryptamine

1985 ◽  
pp. 223-228
Author(s):  
Adil J. Nazarali ◽  
Glen B. Baker ◽  
Ronald T. Coutts ◽  
David R. Hampson ◽  
Tse W. Hall ◽  
...  
Keyword(s):  
Trace Amines ◽  
Brain Levels
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