Bacterial survival strategies suggest rethinking cancer cooperativity

2012 ◽  
Vol 20 (9) ◽  
pp. 403-410 ◽  
Author(s):  
Eshel Ben-Jacob ◽  
Donald S. Coffey ◽  
Herbert Levine
Keyword(s):  
Survival Strategies ◽  
Bacterial Survival

Bacterial Survival Strategies

2004 ◽  
pp. 115-118
Author(s):  
Cindy E. Morris ◽  
Christine M. H. Riffaud
Keyword(s):  
Survival Strategies ◽  
Bacterial Survival

Bacterial Survival Strategies in an Alkaline Tailing Site and the Physiological Mechanisms of Dominant Phylotypes As Revealed by Metagenomic Analyses

2018 ◽  
Vol 52 (22) ◽  
pp. 13370-13380 ◽  
Author(s):  
Weimin Sun ◽  
Enzong Xiao ◽  
Max Häggblom ◽  
Valdis Krumins ◽  
Yiran Dong ◽  
...  
Keyword(s):  
Survival Strategies ◽  
Bacterial Survival ◽  
Physiological Mechanisms

The classification of bacterial survival strategies in the presence of antimicrobials

2021 ◽  
Vol 155 ◽  
pp. 104901
Author(s):  
Igor V. Chebotar’ ◽  
Marina A. Emelyanova ◽  
Julia A. Bocharova ◽  
Nikolay A. Mayansky ◽  
Elena E. Kopantseva ◽  
...  
Keyword(s):  
Survival Strategies ◽  
Bacterial Survival

scholarly journals Regulation of major bacterial survival strategies by transcript sequestration in a membraneless organelle

2022 ◽  
Author(s):  
Tamar Szoke ◽  
Nitsan Albocher ◽  
Omer Goldberger ◽  
Meshi Barsheshet ◽  
Anat Nussbaum-Shochat ◽  
...  
Keyword(s):  
Phase Separation ◽  
Bacterial Cell ◽  
Spatial Organization ◽  
Sugar Metabolism ◽  
Survival Strategies ◽  
Bacterial Survival ◽  
Cell Content ◽  
E Coli ◽  
Liquid To Solid Transition ◽  
Bacterial Cell Morphology

Liquid-liquid phase separation (LLPS) of proteins was shown in recent years to regulate spatial organization of cell content without the need for membrane encapsulation in eukaryotes and prokaryotes. Yet evidence for the relevance of LLPS for bacterial cell functionality is largely missing. Here we show that the sugar metabolism-regulating clusters, recently shown by us to assemble in the E. coli cell poles by means of the novel protein TmaR, are formed via LLPS. A mutant screen uncovered residues and motifs in TmaR that are important for its condensation. Upon overexpression, TmaR undergoes irreversible liquid-to-solid transition, similar to the transition of disease-causing proteins in human, which impairs bacterial cell morphology and proliferation. Not only does RNA contribute to TmaR phase separation, but by ensuring polar localization and stability of flagella-related transcripts, TmaR enables cell motility and biofilm formation, thus providing a linkage between LLPS and major survival strategies in bacteria.

scholarly journals Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

2015 ◽  
Vol 197 (7) ◽  
pp. 1146-1156 ◽  
Author(s):  
Anthony O. Gaca ◽  
Cristina Colomer-Winter ◽  
José A. Lemos
Keyword(s):  
Bacterial Species ◽  
Cell Formation ◽  
Stringent Response ◽  
Survival Strategies ◽  
Cell Physiology ◽  
Bacterial Survival ◽  
Stress Survival ◽  
Rapid Accumulation ◽  
Relationship Of

In nearly all bacterial species examined so far, amino acid starvation triggers the rapid accumulation of the nucleotide second messenger (p)ppGpp, the effector of the stringent response. While for years the enzymes involved in (p)ppGpp metabolism and the significance of (p)ppGpp accumulation to stress survival were considered well defined, a recent surge of interest in the field has uncovered an unanticipated level of diversity in how bacteria metabolize and utilize (p)ppGpp to rapidly synchronize a variety of biological processes important for growth and stress survival. In addition to the classic activation of the stringent response, it has become evident that (p)ppGpp exerts differential effects on cell physiology in an incremental manner rather than simply acting as a biphasic switch that controls growth or stasis. Of particular interest is the intimate relationship of (p)ppGpp with persister cell formation and virulence, which has spurred the pursuit of (p)ppGpp inhibitors as a means to control recalcitrant infections. Here, we present an overview of the enzymes responsible for (p)ppGpp metabolism, elaborate on the intricacies that link basal production of (p)ppGpp to bacterial homeostasis, and discuss the implications of targeting (p)ppGpp synthesis as a means to disrupt long-term bacterial survival strategies.

scholarly journals Antibiotics: Combatting Tolerance To Stop Resistance

mBio ◽  
2019 ◽  
Vol 10 (5) ◽  
Author(s):  
Etthel M. Windels ◽  
Joran E. Michiels ◽  
Bram Van den Bergh ◽  
Maarten Fauvart ◽  
Jan Michiels
Keyword(s):  
Antibiotic Resistance ◽  
Genetic Resistance ◽  
Survival Strategies ◽  
Screening Methods ◽  
Bacterial Survival ◽  
Recurrent Infections ◽  
Therapy Failure ◽  
Improve Treatment ◽  
Modern Health Care ◽  
Emergence Of Resistance

ABSTRACT Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens. Problematically, routine screening methods and strategies to restrict therapy failure almost exclusively focus on genetic resistance, while evidence for dangers posed by other bacterial survival strategies is mounting. Antibiotic tolerance, occurring either population-wide or in a subpopulation of cells, allows bacteria to transiently overcome antibiotic treatment and is overlooked in clinical practice. In addition to prolonging treatment and causing relapsing infections, recent studies have revealed that tolerance also accelerates the emergence of resistance. These critical findings emphasize the need for strategies to combat tolerance, not only to improve treatment of recurrent infections but also to effectively address the problem of antibiotic resistance at the root.

Bacterial survival strategies and responses under heavy metal stress: a comprehensive overview

2021 ◽  
pp. 1-29
Author(s):  
Ayon Pal ◽  
Sukanya Bhattacharjee ◽  
Jayanti Saha ◽  
Monalisha Sarkar ◽  
Parimal Mandal
Keyword(s):  
Heavy Metal ◽  
Heavy Metal Stress ◽  
Metal Stress ◽  
Survival Strategies ◽  
Bacterial Survival ◽  
Comprehensive Overview

scholarly journals Metal-Pseudomonas veronii 2E Interactions as Strategies for Innovative Process Developments in Environmental Biotechnology

2021 ◽  
Vol 12 ◽  
Author(s):  
María Pia Busnelli ◽  
Irene C. Lazzarini Behrmann ◽  
Maria Laura Ferreira ◽  
Roberto J. Candal ◽  
Silvana A. Ramirez ◽  
...  
Keyword(s):  
Survival Strategies ◽  
Batch Reactors ◽  
Bacterial Survival ◽  
Carbon Paste ◽  
Whole Cells ◽  
Metal Retention ◽  
Biosorption Mechanism ◽  
Exopolymeric Substances ◽  
Versatile Tool ◽  
Pseudomonas Veronii

The increase of industrial discharges is the first cause of the contamination of water bodies. The bacterial survival strategies contribute to the equilibrium restoration of ecosystems being useful tools for the development of innovative environmental biotechnologies. The aim of this work was to study the Cu(II) and Cd(II) biosensing, removal and recovery, mediated by whole cells, exopolymeric substances (EPS) and biosurfactants of the indigenous and non-pathogenic Pseudomonas veronii 2E to be applied in the development of wastewater biotreatments. An electrochemical biosensor was developed using P. veronii 2E biosorption mechanism mediated by the cell surface associated to bound exopolymeric substances. A Carbon Paste Electrode modified with P. veronii 2E (CPEM) was built using mineral oil, pre-washed graphite power and 24 h-dried cells. For Cd(II) quantification the CPEM was immersed in Cd(II) (1–25 μM), detected by Square Wave Voltammetry. A similar procedure was used for 1–50 μM Cu(II). Regarding Cd(II), removal mediated by immobilized EPS was tested in a 50 ml bioreactor with 0.13 mM Cd(II), pH 7.5. A 54% metal retention by EPS was achieved after 7 h of continuous operation, while a 40% was removed by a control resin. In addition, surfactants produced by P. veronii 2E were studied for recovery of Cd(II) adsorbed on diatomite, obtaining a 36% desorption efficiency at pH 6.5. Cu(II) adsorption from a 1 mM solution was tested using P. veronii 2E purified soluble EPS in 50 mL- batch reactors (pH = 5.5, 32°C). An 80% of the initial Cu(II) was retained using 1.04 g immobilized EPS. Focusing on metal recovery, Cu nanoparticles (NPs) biosynthesis by P. veronii 2E was carried out in Cu(II)-PYG Broth at 25°C for 5 days. Extracellular CuNPs were characterized by UV-Vis spectral analysis while both extracellular and intracellular NPs were analyzed by SEM and TEM techniques. Responses of P. veronii 2E and its products as biosurfactants, bound and soluble EPS allowed Cu(II) and Cd(II) removal, recovery and biosensing resulting in a multiple and versatile tool for sustainable wastewater biotreatments.

scholarly journals Transcriptome analysis unveils survival strategies of Streptococcus parauberis against fish serum

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252200
Author(s):  
Yoonhang Lee ◽  
Nameun Kim ◽  
HyeongJin Roh ◽  
Ahran Kim ◽  
Hyun-Ja Han ◽  
...  
Keyword(s):  
Culture Conditions ◽  
Survival Strategies ◽  
Olive Flounder ◽  
Organic Substrates ◽  
Bacterial Survival ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Genome Wide ◽  
Streptococcus Parauberis ◽  
Hyaluronic Acid Capsule

Streptococcus parauberis is an important bacterial fish pathogen that causes streptococcosis in a variety of fish species including the olive flounder. Despite its importance in the aquaculture industry, little is known about the survival strategy of S. parauberis in the host. Therefore, the objective of this study was to produce genome-wide transcriptome data and identify key factors for the survival of S. parauberis SPOF3K in its host. To this end, S. parauberis SPOF3K was incubated in olive flounder serum and nutrient-enriched media as a control. Although S. parauberis SPOF3K proliferated in both culture conditions, the transcriptomic patterns of the two groups were very different. Interestingly, the expression levels of genes responsible for the replication of an S. parauberis plasmid in the presence of olive flounder serum were higher than those in the absence of olive flounder serum, indicating that this plasmid may play an important role in the survival and proliferation of S. parauberis in the host. Several ATP-binding cassette transporters known to transport organic substrates (e.g., biotin and osmoprotectants) that are vital for bacterial survival in the host were significantly up-regulated in S. parauberis cultured in serum. In addition, groEL, dnaK operon, and members of the clp protease family, which are known to play important roles in response to various stressors, were up-regulated in S. parauberis incubated in serum, thus limiting damage and facilitating cellular recovery. Moreover, important virulence factors including the hyaluronic acid capsule (has operon), sortase A (srtA), C5a peptidase (scp), and peptidoglycan O-acetyltransferase (oatA) were significantly upregulated in S. paraubers in serum. These results indicate that S. paraubers can resist and evade the humoral immune responses of fish. The transcriptomic data obtained in this study provide a better understanding of the mode of action of S. parauberis in fish.

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