A general solid phase synthesis of 4-substituted quinolinones via Pd-catalyzed cross coupling

2006 ◽  
Vol 47 (28) ◽  
pp. 4885-4888 ◽  
Author(s):  
Caiding Xu ◽  
Lydie Yang ◽  
Ashok Bhandari ◽  
Christopher P. Holmes
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Phase Synthesis

Solid-phase synthesis of 5-arylhistidines via a microwave-assisted Suzuki–Miyaura cross-coupling

Tetrahedron ◽  
2008 ◽  
Vol 64 (46) ◽  
pp. 10538-10545 ◽  
Author(s):  
Vanessa Cerezo ◽  
Muriel Amblard ◽  
Jean Martinez ◽  
Pascal Verdié ◽  
Marta Planas ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Phase Synthesis ◽  
Microwave Assisted

Solid-Phase Synthesis of Oligo(triacetylene)s and Oligo(phenylenetriacetylene)s EmployingSonogashira andCadiotChodkiewicz-Type Cross-Coupling Reactions

2004 ◽  
Vol 87 (3) ◽  
pp. 698-718 ◽  
Author(s):  
Nils F. Utesch ◽  
François Diederich ◽  
Corinne Boudon ◽  
Jean-Paul Gisselbrecht ◽  
Maurice Gross
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Phase Synthesis ◽  
Cross Coupling Reactions

Solid-Phase Synthesis of 5-Arylhistidine-Containing Peptides with Antimicrobial Activity Through a Microwave-Assisted Suzuki-Miyaura Cross-Coupling

2012 ◽  
Vol 2012 (23) ◽  
pp. 4321-4332 ◽  
Author(s):  
Iteng Ng-Choi ◽  
Marta Soler ◽  
Vanessa Cerezo ◽  
Esther Badosa ◽  
Emilio Montesinos ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Phase Synthesis ◽  
Microwave Assisted

Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling

2011 ◽  
Vol 64 (5) ◽  
pp. 540 ◽  
Author(s):  
Jae Wook Lee ◽  
Hyung-Ho Ha ◽  
Marc Vendrell ◽  
Jacqueline T. Bork ◽  
Young-Tae Chang
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Structural Diversity ◽  
Suzuki Coupling ◽  
Purification Step ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Triazine Derivatives ◽  
Polymer Supported

A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.

scholarly journals Solid-phase synthesis of biaryl bicyclic peptides containing a 3-aryltyrosine or a 4-arylphenylalanine moiety

2019 ◽  
Vol 15 ◽  
pp. 761-768 ◽  
Author(s):  
Iteng Ng-Choi ◽  
Àngel Oliveras ◽  
Lidia Feliu ◽  
Marta Planas
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Phase Synthesis ◽  
Microwave Assisted ◽  
Bicyclic Compounds ◽  
Key Steps

A methodology for the solid-phase synthesis of biaryl bicyclic peptides containing a Phe-Phe, a Phe-Tyr or a Tyr-Tyr motif has been devised. This approach comprises two key steps. The first one involves the cyclization of a linear peptidyl resin containing the corresponding halo- and boronoamino acids via a microwave-assisted Suzuki–Miyaura cross coupling. This step is followed by the macrolactamization of the resulting biaryl monocyclic peptidyl resin leading to the formation of the expected biaryl bicyclic peptide. This study provides the first solid-phase synthesis of this type of bicyclic compounds being amenable to prepare a diversity of synthetic or natural biaryl bicyclic peptides.

A Novel Strategy for the Solid Phase Synthesis of Ultra Pure Organic Semiconductors

2003 ◽  
Vol 771 ◽  
Author(s):  
D. Turner ◽  
A. Spivey ◽  
D. Cupertino ◽  
P. Mackie ◽  
R. Anemian ◽  
...  
Keyword(s):  
Organic Semiconductors ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Phase Synthesis ◽  
Synthetic Strategy ◽  
Novel Strategy ◽  
Key Steps ◽  
Iterative Synthesis

AbstractA new solid phase synthetic strategy for the production of organic semiconductors has been developed. The strategy uses a germanium-based linker and Suzuki-type cross-coupling protocols and has been demonstrated for the iterative synthesis of both a regio-regular oligo-3-alkyl-thiophene and an oligoarylamine. The process also incorporates a novel “doublecoupling” after each iteration which minimizes deletion sequences. The key steps exploits the susceptibility of α-silyl- or α-silyloxy- but not germyl-substituted derivatives toward nucleophilic ipso-protodemetalation.

Sign in / Sign up

Export Citation Format

Share Document