Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

S. Chandrasekhar; N. Ramakrishna Reddy; Y. Srinivasa Rao

doi:10.1016/j.tet.2006.09.056

Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

Tetrahedron ◽

10.1016/j.tet.2006.09.056 ◽

2006 ◽

Vol 62 (51) ◽

pp. 12098-12107 ◽

Cited By ~ 34

Author(s):

S. Chandrasekhar ◽

N. Ramakrishna Reddy ◽

Y. Srinivasa Rao

Keyword(s):

Building Blocks ◽

Asymmetric Dihydroxylation ◽

Michael Reactions ◽

Synthetic Studies ◽

Ecteinascidin 743

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Synthetic Studies on Ecteinascidin 743 (I): Asymmetric Synthesis of the Versatile Amino Acid Component (II).

ChemInform ◽

10.1002/chin.200339207 ◽

2003 ◽

Vol 34 (39) ◽

Author(s):

Wei Jin ◽

Robert M. Williams

Keyword(s):

Amino Acid ◽

Asymmetric Synthesis ◽

Acid Component ◽

Amino Acid Component ◽

Synthetic Studies ◽

Ecteinascidin 743

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Synthetic studies on ecteinascidin 743: asymmetric synthesis of the versatile amino acid component

Tetrahedron Letters ◽

10.1016/s0040-4039(03)01082-7 ◽

2003 ◽

Vol 44 (25) ◽

pp. 4635-4639 ◽

Cited By ~ 20

Author(s):

Wei Jin ◽

Robert M Williams

Keyword(s):

Amino Acid ◽

Asymmetric Synthesis ◽

Acid Component ◽

Amino Acid Component ◽

Synthetic Studies ◽

Ecteinascidin 743

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 6. Synthesis of the C1-C15 Unit via Stereoselective Construction of the B and A Rings by Kinetically and Thermodynamically Controlled Michael Reactions with the Aid of Computational Search for Dominant Conformers.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1265 ◽

1997 ◽

Vol 45 (8) ◽

pp. 1265-1281 ◽

Cited By ~ 16

Author(s):

Kiyoshi HORITA ◽

Shun-ichiro HACHIYA ◽

Tatsuya YAMAZAKI ◽

Tae NAITOU ◽

Jun'ichi UENISHI ◽

...

Keyword(s):

Marine Sponge ◽

Halichondrin B ◽

Michael Reactions ◽

Computational Search ◽

Synthetic Studies

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Synthetic Studies on Biologically Active Alkaloids Starting from Lactam-type Chiral Building Blocks

ChemInform ◽

10.1002/chin.200434280 ◽

2004 ◽

Vol 35 (34) ◽

Author(s):

Naoki Toyooka ◽

Hideo Nemoto

Keyword(s):

Building Blocks ◽

Biologically Active ◽

Synthetic Studies

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ChemInform Abstract: Synthetic Studies towards Spirostaphylotrichins: Synthesis of Building Blocks.

ChemInform ◽

10.1002/chin.199401300 ◽

2010 ◽

Vol 25 (1) ◽

pp. no-no

Author(s):

O. STEINER ◽

C. TAMM

Keyword(s):

Building Blocks ◽

Synthetic Studies

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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 1. Stereoselective Synthesis of the C1-C13 FragmentviaConstruction of the B and A Rings by Kinetically and thermodynamically Controlled Intramolecular Michael Reactions.

Synlett ◽

10.1055/s-1994-22730 ◽

1994 ◽

Vol 1994 (01) ◽

pp. 38-40 ◽

Cited By ~ 26

Author(s):

K. Horita ◽

S. Hachiya ◽

M. Nagasawa ◽

M. Hikota ◽

O. Yonemitsu

Keyword(s):

Marine Sponge ◽

Stereoselective Synthesis ◽

Halichondrin B ◽

Michael Reactions ◽

Synthetic Studies

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Synthetic Studies of 2,2-Difluorobicyclo[1.1.1]pentanes (BCP-F2 ): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists

European Journal of Organic Chemistry ◽

10.1002/ejoc.202000679 ◽

2020 ◽

Vol 2020 (29) ◽

pp. 4581-4605

Author(s):

Xiaoshen Ma ◽

Wilfredo Pinto ◽

Luu N. Pham ◽

David L. Sloman ◽

Yongxin Han

Keyword(s):

Building Blocks ◽

Synthetic Studies

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2-Keto Sugars as Preformed Heterocyclic Building Blocks. Synthetic Studies

Heterocycles ◽

10.3987/com-92-s(t)123 ◽

1993 ◽

Vol 35 (2) ◽

pp. 1247 ◽

Cited By ~ 4

Author(s):

Timothy C. Gallagher ◽

Andrew M. Griffin ◽

Nicholas J. Newcombe ◽

David Alker ◽

Michael V. J. Ramsay ◽

...

Keyword(s):

Building Blocks ◽

Synthetic Studies

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ChemInform Abstract: Asymmetric Dihydroxylation Affords Enantiomerically Pure C12 Building Blocks from trans,trans,cis-1,5,9-Cyclododecatriene.

ChemInform ◽

10.1002/chin.199551094 ◽

2010 ◽

Vol 26 (51) ◽

pp. no-no

Author(s):

U. HUGGER ◽

K. B. SHARPLESS

Keyword(s):

Building Blocks ◽

Enantiomerically Pure ◽

Asymmetric Dihydroxylation

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1998 Alfred Bader Award Lecture Tangents and targets: The synthetic highway from natural products to medicine

Canadian Journal of Chemistry ◽

10.1139/v98-233 ◽

1999 ◽

Vol 77 (2) ◽

pp. 159-177 ◽

Cited By ~ 23

Author(s):

Alex G Fallis

Keyword(s):

Natural Products ◽

Building Blocks ◽

Diels Alder ◽

Synthetic Studies

Synthetic studies directed toward various classes of compounds including taxoids and enediyne systems are described. These investigations include tether-controlled imtramolecular Diels-Alder reactions, carbometallation routes to dienes and furans, the use of carbohydrate building blocks, pentadienyl indium reagents for tandem cycloadditions to steroid and triterpenoid skeletons, and the synthesis of taxamycins and revolveneynes and related cyclophanes.Key words: cycloaddition, taxoids, enediyne, cyclophanes, carbometallation.

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