2-(2-Hydroxyaryl)cinnamic amides: a new class of axially chiral molecules

Tetrahedron ◽  
2006 ◽  
Vol 62 (38) ◽  
pp. 8943-8951 ◽  
Author(s):  
Chiara Marelli ◽  
Chiara Monti ◽  
Simona Galli ◽  
Norberto Masciocchi ◽  
Umberto Piarulli
Keyword(s):  
Chiral Molecules ◽  
New Class ◽  
Axially Chiral

scholarly journals Novel π-expanded chrysene-based axially chiral molecules: 1,1′-bichrysene-2,2′-diols and thiophene analogs

2020 ◽  
Vol 44 (11-12) ◽  
pp. 641-645
Author(s):  
Shujie An ◽  
Guofeng Tang ◽  
Yaling Zhong ◽  
Li Ma ◽  
Qiancai Liu
Keyword(s):  
Wittig Reaction ◽  
Suzuki Coupling ◽  
Chiral Molecules ◽  
Axially Chiral ◽  
Key Steps

1,1′-Bichrysene-2,2′-diol and its thiophene analogs, 6,6′-biphenanthro-[1,2- b]thiophene-7,7′-diols, as a series of novel π-expanded chrysene-/phenanthro[1,2- b]thiophene-based axially chiral molecules are synthesized from 1,1′-bi-2-naphthols with key steps including a Suzuki coupling, a Wittig reaction, and acid-mediated cyclization.

Axially Chiral Amidinium Ions with a Biaryl Skeleton: A New Class of Structure in Host–Guest Chemistry

1994 ◽  
Vol 33 (9) ◽  
pp. 984-986 ◽  
Author(s):  
Stefan Lehr ◽  
Karin Schütz ◽  
Markus Bauch ◽  
Michael W. Göbel
Keyword(s):  
New Class ◽  
Axially Chiral ◽  
Guest Chemistry

scholarly journals Organocatalytic atroposelective heterocycloaddition to access axially chiral 2-arylquinolines

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Gongming Yang ◽  
Shaofa Sun ◽  
Zhipeng Li ◽  
Yuhan Liu ◽  
Jian Wang
Keyword(s):  
Drug Discovery ◽  
Asymmetric Synthesis ◽  
Vital Role ◽  
Optically Active ◽  
Enantioselective Synthesis ◽  
Chiral Amine ◽  
New Class ◽  
Axially Chiral ◽  
High Yields

AbstractAxially chiral heterobiaryls play a vital role in asymmetric synthesis and drug discovery. However, there are few reports on the synthesis of atropisomeric heterobiaryls compared with axially chiral biaryls. Thus, the rapid enantioselective construction of optically active heterobiaryls and their analogues remains an attractive challenge. Here, we report a concise chiral amine-catalyzed atroposelective heterocycloaddition reaction of alkynes with ortho-aminoarylaldehydes, and obtain a new class of axially chiral 2-arylquinoline skeletons with high yields and excellent enantioselectivities. In addition, the axially chiral 2-arylquinoline framework with different substituents is expected to be widely used in enantioselective synthesis.

Sign in / Sign up

Export Citation Format

Share Document