scholarly journals The Hippo signaling pathway and stem cell biology

2012 ◽  
Vol 22 (7) ◽  
pp. 339-346 ◽  
Author(s):  
Azucena Ramos ◽  
Fernando D. Camargo
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway

scholarly journals The Hippo signaling pathway in stem cell biology and cancer

EMBO Reports ◽  
2014 ◽  
Vol 15 (6) ◽  
pp. 642-656 ◽  
Author(s):  
Jung‐Soon Mo ◽  
Hyun Woo Park ◽  
Kun‐Liang Guan
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway

scholarly journals Ovarian Germline Stem Cells (OGSCs) and the Hippo Signaling Pathway Association with Physiological and Pathological Ovarian Aging in Mice

2015 ◽  
Vol 36 (5) ◽  
pp. 1712-1724 ◽  
Author(s):  
Jia Li ◽  
Fangyue Zhou ◽  
Tuochen Zheng ◽  
Zezheng Pan ◽  
Xia Liang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Signaling Pathway ◽  
Cell Biology ◽  
Control Group ◽  
Hippo Signaling ◽  
Germline Stem Cells ◽  
Hippo Signaling Pathway ◽  
Ovarian Cortex ◽  
Ovarian Aging

Background: The Hippo signaling pathway plays fundamental roles in stem cell maintenance in a variety of tissues and has thus implications for stem cell biology. Key components of this recently discovered pathway have been shown to be associated with primordial follicle activation. However, whether the Hippo signaling pathway plays a role in the development of Ovarian Germline Stem Cells (OGSCs) during physiological and pathological ovarian aging in mice is unknown. Methods: Mice at the age of 7 days (7D), or of 2, 10, or 20 months (2M, 10M, 20M) and mice at 2M treated with TPT and CY/BUS drugs were selected as physiological and pathological ovarian aging models, respectively. Immunohistochemistry was used to assess the development of follicles, and the co-localization of genes characteristic of OGSCs with MST1, LATS2 and YAP1 was assessed by immunofluorescence, western blotting and real-time PCR methods. Results: The Hippo signal pathway and MVH/OCT4 genes were co-expressed in the mouse ovarian cortex. The level and co-localization of LATS2, MST1, MVH, and OCT4 were significantly decreased with increased age, but YAP1 was more prevalent in the mouse ovarian cortex of 2M mice than 7D mice and was not observed in 20M mice. Furthermore, YAP1, MVH, and OCT4 were gradually decreased after TPT and CY/BUS treatment, and LATS2 mRNA and protein up-regulation persisted in TPT- and CY/BUS-treated mice. However, the expression of MST1 was lower in the TPT and CY/BUS groups compared with the control group. In addition, pYAP1 protein showed the highest expression in the ovarian cortexes of 7D mice compared with 20M mice, and the value of pYAP1/YAP1 decreased from 7D to 20M. Moreover, pYAP1 decreased in the TPT- and CY/BUS-treated groups, but the value of pYAP1/YAP1 increased in these groups. Conclusion: Taken together, our results show that the Hippo signaling pathway is associated with the changes that take place in OGSCs during physiological and pathological ovarian aging in mice. Thus, the Hippo signaling pathway may be involved in the development schedule of OGSCs.

Abstract 3662: Honokiol affects stem cell viability in part through suppression of Hippo signaling pathway.

2013 ◽  
Author(s):  
Dharmalingam Subramaniam ◽  
Sivapriya Ponnurangam ◽  
Shahid Umar ◽  
Satish Ramalingam ◽  
Roy A. Jensen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Viability ◽  
Signaling Pathway ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway

Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway

2015 ◽  
Vol 465 (2) ◽  
pp. 194-199 ◽  
Author(s):  
Guohua Zhu ◽  
Yun Wang ◽  
Maimaitili Mijiti ◽  
Zengliang Wang ◽  
Peng-Fei Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway

scholarly journals A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1630 ◽  
Author(s):  
Kirsten Strømme Kierulf-Vieira ◽  
Cecilie Jonsgar Sandberg ◽  
Jo Waaler ◽  
Kaja Lund ◽  
Erlend Skaga ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Small Molecule ◽  
Hippo Signaling ◽  
Dependent Manner ◽  
In Vitro Proliferation ◽  
Hippo Signaling Pathway ◽  
Related Proteins ◽  
Sphere Formation

Evidence suggests that the growth and therapeutic resistance of glioblastoma (GBM) may be enabled by a population of glioma stem cells (GSCs) that are regulated by typical stem cell pathways, including the WNT/β-catenin signaling pathway. We wanted to explore the effect of treating GSCs with a small-molecule inhibitor of tankyrase, G007-LK, which has been shown to be a potent modulator of the WNT/β-catenin and Hippo pathways in colon cancer. Four primary GSC cultures and two primary adult neural stem cell cultures were treated with G007-LK and subsequently evaluated through the measurement of growth characteristics, as well as the expression of WNT/β-catenin and Hippo signaling pathway-related proteins and genes. Treatment with G007-LK decreased in vitro proliferation and sphere formation in all four primary GSC cultures in a dose-dependent manner. G007-LK treatment altered the expression of key downstream WNT/β-catenin and Hippo signaling pathway-related proteins and genes. Finally, cotreatment with the established GBM chemotherapeutic compound temozolomide (TMZ) led to an additive reduction in sphere formation, suggesting that WNT/β-catenin signaling may contribute to TMZ resistance. These observations suggest that tankyrase inhibition may serve as a supplement to current GBM therapy, although more work is needed to determine the exact downstream mechanisms involved.

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