Thermal analysis and quantitative characterization of compatibility between diflunisal and lipid excipients as raw materials for development of solid lipid nanoparticles

2016 ◽  
Vol 643 ◽  
pp. 23-32 ◽  
Author(s):  
Amanpreet Kaur ◽  
Shishu Goindi ◽  
Om Prakash Katare
Keyword(s):  
Thermal Analysis ◽  
Solid Lipid Nanoparticles ◽  
Raw Materials ◽  
Lipid Nanoparticles ◽  
Quantitative Characterization ◽  
Solid Lipid ◽  
Lipid Excipients

Characterization of silver sulfadiazine-loaded solid lipid nanoparticles by thermal analysis

2012 ◽  
Vol 111 (3) ◽  
pp. 2149-2155 ◽  
Author(s):  
Catenacci Laura ◽  
Sorrenti Milena ◽  
Bruni Giovanna ◽  
Bonferoni Maria Cristina ◽  
Sandri Giuseppina ◽  
...  
Keyword(s):  
Thermal Analysis ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Silver Sulfadiazine ◽  
Solid Lipid

Preparation and characterization of chloroaluminum phthalocyanine-loaded solid lipid nanoparticles by thermal analysis and powder X-ray diffraction techniques

2011 ◽  
Vol 108 (1) ◽  
pp. 191-196 ◽  
Author(s):  
Ellen Denise P. Almeida ◽  
Adjane A. Costa ◽  
Mairim R. Serafini ◽  
Fábia C. Rossetti ◽  
Juliana M. Marchetti ◽  
...  
Keyword(s):  
Thermal Analysis ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Solid Lipid ◽  
Chloroaluminum Phthalocyanine

Nephrotoxicity of Albendazole and Albendazole-Loaded Solid Lipid Nanoparticles in Mice with Experimental Hydatidosis

2021 ◽  
Author(s):  
Kobra Kohansal ◽  
Abdollah Rafiei ◽  
Heibatullah Kalantari ◽  
Ali Jelowdar ◽  
Anayatollah Salimi ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characterization ◽  
Public Health Problem ◽  
New Product ◽  
Lipid Nanoparticles ◽  
Control Group ◽  
Histopathological Study ◽  
Normal Range ◽  
Solid Lipid

Purposes: Cystic echinococcosis (CE) is a serious contemporary public health problem. Different CE treatment methods are of considerable importance, with albendazole (ABZ) being one of the most preferred drugs for CE treatment and prophylaxis. In this study, we evaluated the nephrotoxicity caused by ABZ and ABZ-loaded solid lipid nanoparticles (SLNs) in mice with experimental hydatid cyst. Methods: ABZ-loaded SLNs were produced by micro-emulsification and a high shear homogenization technique. Thereafter, we evaluated the physicochemical characterization of the product. Live protoscolices were injected into mice to induce experimental hydatidosis. Mice were then treated with ABZ and ABZ-loaded SLNs. The nephrotoxicity effects were evaluated by biochemical and histopathological surveys. Results: Significantly different blood urea nitrogen (BUN) levels were observed between the two infected groups (ABZ treatment and ABZ-loaded SLN treatment) and the control group. The kidney malondialdehyde (MDA) and glutathione (GSH) levels of the infected groups were not significantly different from those of the control group. The histopathological study revealed nephropathic and pathologic changes in the ABZ and ABZ-loaded SLN groups. Conclusion: ABZ formulated for ABZ-loaded SLNs had a more prominent chemoprophylactic efficacy on CE and fewer side effects than ABZ alone. Neither ABZ nor ABZ-loaded SLNs caused significant biochemical and histopathological defects on the kidney, and all functional biochemical markers stayed within the normal range. Therefore, ABZ-loaded SLNs could be a potential new product for CE treatment.

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