Synthesis and distinct urease enzyme inhibitory activities of metal complexes of Schiff-base ligands: Kinetic and thermodynamic parameters evaluation from TG-DTA analysis

2013 ◽  
Vol 555 ◽  
pp. 72-80 ◽  
Author(s):  
Muhammad Ikram ◽  
Sadia Rehman ◽  
Faridoon ◽  
Robert J. Baker ◽  
Hanif Ur Rehman ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Thermodynamic Parameters ◽  
Schiff Base Ligands ◽  
Kinetic And Thermodynamic Parameters ◽  
Urease Enzyme ◽  
Dta Analysis ◽  
Inhibitory Activities

scholarly journals Synthesis, Structure and Reactivity of Schiff Base Transition Metal Mixed Ligand Complexes Derived from Isatin and Salal

2021 ◽  
Vol 37 (1) ◽  
pp. 169-176
Author(s):  
Sridevi S P ◽  
Girija C R ◽  
C D Satish
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Nucleophilic Addition ◽  
Biological Activities ◽  
Main Idea ◽  
Molar Conductance ◽  
Mixed Ligand ◽  
Schiff Base Ligands ◽  
Dta Analysis ◽  
Pharmaceutical Industries

A series of Isatin derivative Schiff Base ligands have been prepared by the nucleophilic addition of 5-Bromo Isatin with various amine derivatives and characterized by CHNS analysis and spectral data. Similarly, two of Salicylaldehyde ligand have been prepared by the nucleophilic addition of Salal with amine derivatives. In order to investigate the coordination behavior of these ligands and their metal complexes of the type M(acac)x, L [M = Cu(II), Ni(II); L = Schiff base ligands; x = 0 or 2] mixed ligand (chelate) have been prepared from the reaction of these ligands with their corresponding metal (Ni, Cu) acetylacetonates. The present paper was an approach to understand the chelating mixed ligand formation in complexes. All the isolated Shiff base ligands and mixed acac metal complexes were characterized by using IR, 1H NMR, UV-VIS, molar conductance and TGA/DTA analysis. The biological activities of all the isolated ligands and their corresponding mixed acac metal complexes have been used to screening against the microorganisms both gram positive and gram negative bacteria such as E.coli and S.sureus respectively, fungi A.niger and C.albicans and the results have been compared with standard and control. The main idea of these types of biological screening is to understand the role of these isolated compounds in pharmaceutical industries for drug development.

scholarly journals Metal Complexes with Schiff Base Ligands: Pyridoxal and Semicarbazide-Based Derivatives

ChemInform ◽  
2005 ◽  
Vol 36 (52) ◽  
Author(s):  
Vukadin M. Leovac ◽  
Violeta S. Jevtovic ◽  
Ljiljana S. Jovanovic ◽  
Goran A. Bogdanovic
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligands

scholarly journals SYNTHESIS, MOLLUSCICIDALAND ANTIMICROBIAL POTENTIALITIES OF IRON TRIAD MONONUCLEAR METAL COMPLEXES INCORPORATING TRIDENTATE ASYMMETRICAL SCHIFF BASE LIGANDS CONTAINING SOFT SULFUR COORDINATING ATOM

2019 ◽  
pp. 103-113
Author(s):  
AMAL M ALOSAIMI ◽  
INES EL MANNOUBI ◽  
SAMI A ZABIN
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Metal Ion ◽  
Lethal Dose ◽  
Analytical Techniques ◽  
Central Metal ◽  
Schiff Base Ligands ◽  
Molluscicidal Activity

Objective: This work aimed at synthesizing tridentates asymmetrical Schiff base ligands containing sulfur atom and using them for preparing metal complexes with the iron triad metals. The prepared compounds were assayed in vitro for antimicrobial potential and in vivo molluscicidal activity. Methods: The unsymmetrical tridentate Schiff bases (SL1, SL2, and SL3) were prepared using 2-aminothiophenol as primary amine and condensed with 2-carboxybenzaldehyde, 2-hydroxy-1-naphthaldehyde, and 7-formyl-8-hydroxyquinoline. These ligands were used in preparing metal complexes with iron triad metals. The synthesized Schiff base ligands and their corresponding metal complexes were characterized and their proposed structures were confirmed using different physical and spectroscopic analytical techniques. All ligands and their corresponding metal complexes were assayed against different bacterial and fungal strains using the agar disk-diffusion technique. The molluscicidal activity was performed according to the standard reported methods as cited in the literature and by observing the toxicity and lethal dose according to the WHO guidelines. Results: The synthesized ligands behave as tridentate (NOS) ligands and form mononuclear complexes with the general formula [M(SL)2] with an octahedral geometry around the central metal ion. Metal complexes were non-electrolytic in nature. The in vitro antibacterial and antifungal examination results showed weak activity of the ligands, and there was enhanced activity with the complexes. The in vivo molluscicidal activity of the tested compounds showed good activity. Conclusion: The targeted compounds were prepared successfully, characterized, and showed some biological activity but lower than the standard reference drugs.

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