Influence of functionalization on interaction and drug release from α,β-polyaspartylhydrazide derivatives to a biomembrane model: evaluation by differential scanning calorimetry technique

2004 ◽  
Vol 423 (1-2) ◽  
pp. 19-28 ◽  
Author(s):  
Francesco Castelli ◽  
Chiara Messina ◽  
Elisa Martinetti ◽  
Mariano Licciardi ◽  
Emanuela Fabiola Craparo ◽  
...  
Keyword(s):  
Differential Scanning Calorimetry ◽  
Drug Release ◽  
Model Evaluation ◽  
Scanning Calorimetry ◽  
Differential Scanning Calorimetry Technique

Doxorubicin release from optimized electrospun polylactic acid nanofibers

2016 ◽  
Vol 47 (1) ◽  
pp. 71-88 ◽  
Author(s):  
Amir Doustgani
Keyword(s):  
Differential Scanning Calorimetry ◽  
Drug Release ◽  
Polylactic Acid ◽  
Fiber Diameter ◽  
Experimental Result ◽  
Coefficient Of Determination ◽  
Release Mechanism ◽  
Burst Release ◽  
Fiber Morphology ◽  
Scanning Calorimetry

Electrospinning has been known as an efficient method for fabrication of polymer nanofibers. In this study, an electrospun nanofibrous mats based on polylactic acid with a defined release using doxorubicin was developed. The effects of process parameters, such as concentration, distance, applied voltage, temperature and flow rate on the mean diameter of electrospun doxorubicin-loaded polylactic acid nanofibers were investigated. The fiber morphology and mean fiber diameter of prepared nanofibers were investigated by scanning electron microscopy. Differential scanning calorimetry was employed to identify the presence of doxorubicin within nanofibers. Response surface methodology based on a five-level, five-variable central composite design was used to model the average diameter of electrospun polylactic acid/doxorubicin nanofibers. Mean fiber diameter was correlated to these variables by using a polynomial function at a 95% confidence level. The coefficient of determination of the model was found to be 0.93. The predicted fiber diameter was in good agreement with the experimental result. Differential scanning calorimetry results showed that the doxorubicin was loaded into the nanofibers successfully. In vitro drug release in phosphate-buffered solution and acetate buffer for the optimized and non-optimized samples demonstrated that diffusion is the dominant drug release mechanism for drug-loaded fibers. The initial burst release was observed for non-optimized nanofibers compared to optimized nanofibers. Optimized drug-loaded polylactic acid nanofibers could be good candidates for biomedical applications.

Boiling Points of Short-Chain Partial Acylglycerols and Tocopherols at Low Pressures by the Differential Scanning Calorimetry Technique

2014 ◽  
Vol 59 (5) ◽  
pp. 1515-1520 ◽  
Author(s):  
Daniela S. Damaceno ◽  
Rafael M. Matricarde Falleiro ◽  
Maria A. Krähenbühl ◽  
Antonio J. A. Meirelles ◽  
Roberta Ceriani
Keyword(s):  
Differential Scanning Calorimetry ◽  
Short Chain ◽  
Scanning Calorimetry ◽  
Boiling Points ◽  
Low Pressures ◽  
Differential Scanning Calorimetry Technique

scholarly journals “EFFECT OF CROSSLINKING AGENT ON DEVELOPMENT OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF RISEDRONATE SODIUM”

2018 ◽  
Vol 10 (4) ◽  
pp. 133 ◽  
Author(s):  
Shweta Gedam ◽  
Pritee Jadhav ◽  
Swati Talele ◽  
Anil Jadhav
Keyword(s):  
Differential Scanning Calorimetry ◽  
Particle Size ◽  
Drug Release ◽  
Calcium Chloride ◽  
Crosslinking Agent ◽  
Entrapment Efficiency ◽  
Scanning Calorimetry ◽  
Scanning Electron ◽  
Polymer Ratio

Objective: The present investigation was undertaken to develop and evaluate a gastroretentive mucoadhesive microspheres of anti-osteoporosis drug risedronate sodium to enhance the residence time and drug release by studying the effect of the crosslinking agent to obtain the best formulation with reduced particle size and good in vitro mucoadhesion strength.Methods: Selected drug risedronate sodium is a potent pyridinyl bisphosphonate used for the treatment of osteoporosis, and other bone disorders. Microspheres using sodium alginate as a polymer and calcium chloride solution as a cross-linker were prepared successfully by the emulsification crosslinking method. The 23 factorial design was used to study the effects of various variables like a drug: polymer ratio, crosslinking agent concentration and crosslinking time on the particle size and in vitro mucoadhesion strength. All these formulations were evaluated for entrapment efficiency, percentage yield and cumulative drug release. F1 batch was selected as best formulation and evaluated for scanning electron microscopy, fourier transforms infrared spectroscopy, differential scanning calorimetry, stability study.Results: Design batches were evaluated for percent yield (61.29-89.33%), % entrapment efficiency (42.25±0.620-62.58±0.330), mucoadhesion strength (68.15±0.37-82.24±0.72%) and drug release at 12 h (67-84%). Among the microspheres formulation, an F1 batch of (0.5:1) drug: polymer concentration and at 4% concentration of calcium chloride as a crosslinker was considered best formulation with reduced particle size 32.85±0.774μm, % intro mucoadhesion. 82.24±0.72. In vitro mucoadhesion strength was increased with the increasing crosslinking time from 5 min to 10 min. The fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) study showed no interaction between drug and polymer. X-ray diffraction (XRD) spectrum of microspheres indicates that drug particles are dispersed at the molecular level in the polymer matrices so no indication of the crystalline nature of the drug nature. Scanning electron microscopic (SEM) study showed that microspheres were spherical in shape with a smooth surface. F1 batch shows percentage cumulative drug release 84.07%. In vitro dissolution studies indicates that percent cumulative drug release from microspheres follows zero order kinetics plot which indicates controlled-release drug-delivery for 12 h which leads to control of plasma concentration.Conclusion: The results show that the formulation that contains (0.5:1) drug: polymer ratio, calcium chloride in 4% concentration and crosslinking time 10 min is the best one and can be utilized to formulate risedronate sodium mucoadhesive microspheres to enhance gastric residence time, improved patient compliance and reduction in the frequency of drug administration.

Water behavior during drug release from a matrix as observed using differential scanning calorimetry

1995 ◽  
Vol 33 (3) ◽  
pp. 365-374 ◽  
Author(s):  
Shigeru Aoki ◽  
Hidenobu Ando ◽  
Masaaki Ishii ◽  
Sumio Watanabe ◽  
Hiroshi Ozawa
Keyword(s):  
Differential Scanning Calorimetry ◽  
Drug Release ◽  
Scanning Calorimetry ◽  
Water Behavior

Photopyroelectric Calorimeter for Phase Transitions Monitoring: Application to Chocolate

2009 ◽  
Vol 1242 ◽  
Author(s):  
E. I. Martínez-Ordoñez ◽  
E. Marín ◽  
J. A. I. Díaz-Góngora ◽  
A. Calderón
Keyword(s):  
Differential Scanning Calorimetry ◽  
Thermal Properties ◽  
Phase Transitions ◽  
Materials Science ◽  
Scanning Calorimetry ◽  
Characterization Of Materials ◽  
Thermophysical Characterization ◽  
Monitoring Application ◽  
Differential Scanning Calorimetry Technique

ABSTRACTIn this work we report about the design and construction of a simple and cheap calorimeter for phase transitions monitoring using Peltier elements and based in the well known inverse (front) photopyroelectric method for thermophysical characterization of materials. We describe its application for the detection of phase transitions in chocolate samples, as an alternative, for example, to the most widely used and more expensive Differential Scanning Calorimetry technique. The manufacture of chocolate requires an understanding of the chemistry and the physical properties of the product. Thus the involved problems during the confection process are those of the so-called materials science. Among them, those related with tempering are of particular importance. Because the fats in cocoa butter experience the so-called polymorphous crystallization, the primary purpose of tempering is to assure that only the best form is present in the final product. One way to characterize this is by measurement of the temperature dependence of the thermal properties of the chocolate and the monitoring of the temperature at which phase transitions take place. We show that the photopyroelectric method, aided with Peltier cells temperature control, can be a useful choice for this purpose.

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