Simultaneous determination of tetracyclines in pharmaceuticals by CZE using experimental design

Talanta ◽  
2006 ◽  
Vol 70 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Mónica Cecilia Vargas Mamani ◽  
Jaime Amaya Farfán ◽  
Felix Guillermo Reyes Reyes ◽  
Susanne Rath
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination

Simultaneous determination of streptomycin and oxytetracycline in agricultural antimicrobials by CZE after an experimental design

2007 ◽  
Vol 43 (2) ◽  
pp. 450-456 ◽  
Author(s):  
Patrícia Penido Maia ◽  
Jaime Amaya-Farfán ◽  
Susanne Rath ◽  
Felix Guillermo Reyes Reyes
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination

Optimization of UA-DLLME by experimental design methodologies for the simultaneous determination of endosulfan and its metabolites in soil and urine samples by GC–MS

2012 ◽  
Vol 4 (11) ◽  
pp. 3855 ◽  
Author(s):  
Mohana Krishna Reddy Mudiam ◽  
Ratnasekhar Ch ◽  
Abhishek Chauhan ◽  
Natesan Manickam ◽  
Rajeev Jain ◽  
...  
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Urine Samples ◽  
Design Methodologies

Development of an optimized HPLC method for the simultaneous determination of six compounds containing β-lactam ring in human plasma and urine using experimental design methodology

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 9465-9474 ◽  
Author(s):  
Eman A. Abdel Hameed ◽  
Randa A. Abdel Salam ◽  
Ghada M. Hadad
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Design Methodology ◽  
Chromatographic Method ◽  
Biological Fluids ◽  
Hplc Method ◽  
Lactam Ring ◽  
Experimental Design Methodology

β-Lactam antibiotics are commonly prescribed with β-lactamase inhibitors to patients, for that it is necessary to develop an optimized chromatographic method which determine them simultaneously in biological fluids.

scholarly journals Experimental Design of Vortex Assisted Switchable Solvent Homogeneous Liquid-Liquid Microextraction for Simultaneous Determination of Four Pesticides in Wastewater

2020 ◽  
Vol 103 (5) ◽  
pp. 1250-1255
Author(s):  
Büşra Tışlı ◽  
Dotse Selali Chormey ◽  
Merve Fırat Ayyıldız ◽  
Sezgin Bakırdere
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Production Efficiency ◽  
Gas Chromatography Mass Spectrometry ◽  
Real Samples ◽  
Homogeneous Liquid ◽  
Mass Spectrometry System ◽  
Quantification Accuracy ◽  
Liquid Microextraction

Abstract Background Pesticides are chemicals used mainly to protect plant crops in order to increase their production efficiency and quality. Objective Switchable-solvent homogeneous liquid-liquid microextraction was optimized using a Box-Behnken experimental design and validated on a gas chromatography mass spectrometry system for the determination of analytes. Method The significance of independent variables (switchable solvent volume, sodium hydroxide volume, and vortex period) and their interactions were evaluated by analysis of variance at 95% confidence limits (α = 0.05). Results The LOD and LOQ ranges of the analytes were found to be 0.42–1.90 µg/L and 1.36–6.33 µg/L, respectively. Percentage recovery results were found to be in the range of 87–113% in spiking experiments. Conclusions A simple, efficient, and accurate analytical method was developed for the simultaneous determination of the selected pesticides. Highlights: Matrix matching was used to enhance quantification accuracy for real samples. Highlights Matrix matching was used to enhance quantification accuracy for real samples.

Simultaneous determination of cationic dyes in water samples with dispersive liquid–liquid microextraction followed by spectrophotometry: experimental design methodology

2016 ◽  
Vol 40 (5) ◽  
pp. 4793-4802 ◽  
Author(s):  
Arash Asfaram ◽  
Mehrorang Ghaedi
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Water Samples ◽  
Design Methodology ◽  
Cationic Dyes ◽  
Dispersive Liquid Liquid Microextraction ◽  
Experimental Design Methodology ◽  
Liquid Microextraction

Dispersive liquid–liquid microextraction (DLLME) combined with spectrophotometry was applied to the determination of two dyes in water samples.

An Experimental Design for Simultaneous Determination of Carbendazim and Fenamiphos by Electrochemical Method

2015 ◽  
Vol 28 (4) ◽  
pp. 817-822 ◽  
Author(s):  
T. Lima ◽  
H. T. D. Silva ◽  
G. Labuto ◽  
F. R. Simões ◽  
L. Codognoto
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Electrochemical Method

scholarly journals Experimental design approach for the development and validation of an enantiospecific RP-HPLC method for simultaneous determination of clopidogrel and related compounds

2008 ◽  
Vol 27 (1) ◽  
pp. 53 ◽  
Author(s):  
Rumenka Petkovska ◽  
Claus Cornett ◽  
Aneta Dimitrovska
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Mobile Phase ◽  
Hplc Method ◽  
System Response ◽  
Buffer Solution ◽  
Column Temperature ◽  
Rp Hplc ◽  
Related Compounds

An enantiospecific RP-HPLC method was developed and validated for the simultaneous determination of clopidogrel and four related compounds specified as impurities. Experimental design was applied during the method optimization (Full factorial 23 design) and robustness testing (Central Composite Face Centered design). Laboratory mixtures of clopidogrel and its impurities in a concentration ratio of 1: 5.0×10–4 were used as an investigation matrix. The three independent variables were the acetonitrile content in the mobile phase, pH of the mobile phase, and the column temperature. A Chromatographic Response Function (CRF) was used for estimation of the system response resolution (Rs). Separation was achieved using mobile phase composition of ACN: Buffer solution pH 6.5 (40:60 v/v) at 30 ºC. A CHIRAL-AGP 4.0 mm × 100 mm, 5.0 μm particle size column was used. The total time for chromatographic separation was approximately 10.0 min. The method was validated for its selectivity, linearity, precision, accuracy and robustness.

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