scholarly journals Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega−3 polyunsaturated fatty acids

2012 ◽  
Vol 264 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Larry N. Agbor ◽  
Mary T. Walsh ◽  
Jason R. Boberg ◽  
Mary K. Walker
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Knockout Mice ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Omega 3 ◽  
Cytochrome P4501a1

Abstract W P146: Low Serum Level of Eicosapentanoic Acid (EPA) is Associated with Occurrence of Nonlobar Type Intracerebal Hemorrhage (ICH)

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Yasuhisa Akaiwa ◽  
Hiroki Takano ◽  
Hiroyuki Arakawa ◽  
Itaru Ninomiya ◽  
Masahiro Uemura ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Ischemic Stroke ◽  
Polyunsaturated Fatty Acids ◽  
Small Vessel Disease ◽  
Routine Practice ◽  
Large Artery ◽  
Omega 3 ◽  
Stroke Patients ◽  
Stroke Subtypes

Background: : Intake of omega-3 polyunsaturated fatty acids, such as EPA, has been reported to have protective effects on various diseases including ischemic stroke. However, there have been few studies concerning the effect of omega-3 polyunsaturated fatty acids on hemorrhagic stroke. We studied associations of serum levels of EPA with stroke subtypes including primary ICH Methods: We have examined serum EPA and arachidonic acid (AA) levels in routine practice since 2009. To calibrate the EPA values, we calculated EPA/AA ratio. A total of 212 consecutive acute stroke patients and 27 control subjects were included. The patients 40 years old or younger were excluded. Ischemic stroke subtypes were determined based on TOAST criteria. Primary ICH was classified into lobar or nonlobar types, according to the region of the brain in which it occurred. Results: Of all the 157 ischemic stroke patients (female 47, mean age 72.9 years), 62 were classified with cardioembolic stroke (CES), 25 large-artery atherosclerotic (LAA), 22 small-vessel disease (SVD), and 48 other/undetermined causes (O/U). Of all the 55 ICH patients (female 23, mean age 71.0), 34 patients had nonlobar type, and 21 had lobar one. There were no significant intergroup differences in the mean EPA/AA ratio (p=0.525) among CES (EPA/AA= 0.67±0.42), LAA (0.70±0.30), SVD (0.65±0.45), O/U (0.62±0.38), nonlobar ICH (0.51±0.30), lobar ICH (0.64±0.33), and control (0.60±0.42) groups. However, the EPA/AA ratio of the nonlobar ICH group was considerably low. The EPA/AA ratio of the nonlobar ICH group was significantly (p=0.033) lower than that of the whole other groups (0.65±0.39) and significantly (p=0.003) lower than that of the entire ischemic stroke groups (0.67±0.40). Although the significant differences between the nonlobar ICH and the whole ischemic groups were also observed in systolic and diastolic blood pressure (195±37/107±25 mmHg vs 159±35/82±19 mmHg, p<0.001), multiple linear regression analyses showed the association between the EPA/AA and nonlobar ICH was independent from the blood pressure. Conclusions: Although the strongest risk factor for nonlobar ICH is hypertension, low EPA/AA ratio might play a role in the development of nonlobar ICH.

Bezafibrate, an anti-hypertriglyceridemic drug, attenuates vascular hyperresponsiveness and elevated blood pressure in fructose-induced hypertensive rats

1999 ◽  
Vol 77 (10) ◽  
pp. 755-762 ◽  
Author(s):  
Xiaochen Si ◽  
R Clinton Webb ◽  
Joyce M Richey
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipid Profile ◽  
Vascular Reactivity ◽  
Bay K 8644 ◽  
Elevated Blood Pressure ◽  
Male Rats ◽  
Elevated Blood ◽  
Lipid Abnormalities

A high fructose diet induces hypertension, hyperinsulinemia - insulin resistance, and hypertriglyceridemia (syndrome X). In this study, we investigated the role of an abnormal lipid profile in mediating fructose-induced hypertension. We hypothesized that bezafibrate, a lipid-lowering drug, would reduce elevated blood pressure and inhibit increased vascular reactivity in fructose-fed rats. Male rats were placed on four different diets: group 1 was fed standard chow (n = 6); group 2 was fed 60% fructose (n = 5); group 3 was fed fructose plus bezafibrate (30 mg·kg-1·day-1; drinking water; n = 5); and group 4 was fed standard chow plus bezafibrate (n = 6). In addition, the direct effects of very low density lipoprotein (VLDL) on vascular reactivity were examined. Bezafibrate treatment lowered blood pressure, free fatty acids, and triglycerides in the fructose-fed group, suggesting that lipid abnormalities play a role in the elevation of blood pressure in the fructose-induced hypertensive rat. Aortae from fructose-fed rats were hyperresponsive to the calcium channel agonist Bay K 8644, which was normalized with bezafibrate treatment. Incubation of aortae in a VLDL medium resulted in increased responsiveness to Bay K 8644, lending further support to lipid abnormalities altering vascular reactivity. An altered lipid profile evidenced by elevated triglycerides and free fatty acids is causally related to the development of high blood pressure and increased vascular reactivity in the fructose-induced hypertensive rat.Key words: Sprague-Dawley rats, hypertriglyceridemia, free fatty acids, vascular reactivity, aortae.

scholarly journals Arterial hypertension, dysfunction of kidneys and osteoarthrosis in overweighted patients

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
T. O. Ilashchuk ◽  
N. V. Shvets ◽  
T. V. Zakharchuk
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Arterial Hypertension ◽  
Blood Pressure Level ◽  
Review Of Literature ◽  
Omega 3 ◽  
Excessive Weight ◽  
Practice Approach ◽  
Neuronal Systems

Analysis of influence of high blood pressure over the functional state of kidneys in patients with arterial hypertension and concomitant osteoarthrosis, and overweight with estimation of efficiency of omega of -3-polyunsaturated fatty acids application has been carried out in the review of literature. Hormones and cytokines produced by fatty tissues cooperate at the level of the neuronal systems, causing overactivaty of sympathetic nervous system, increase of blood pressure level in case of excessive weight. Unity of pathogenesis of the investigated pathological processes is shown, for treatment of which omega-3-polyunsaturated fatty acids prescription is rational; that will become a basis of perfection of pathogenetically reasonable and inculcated in medical practice approach for treatment of metabolic disorders.

scholarly journals Omega-3 fatty acids and blood pressure

2012 ◽  
Vol 107 (S2) ◽  
pp. S195-S200 ◽  
Author(s):  
Jorge Cabo ◽  
Rodrigo Alonso ◽  
Pedro Mata
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mild Hypertension ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Metabolic Functions ◽  
Blue Fish ◽  
High Doses

Epidemiological and clinical studies suggest that consumption of omega (ω-3) polyunsaturated fatty acids (PUFA) contributes to the reduction of cardiovascular mortality through different mechanisms including modulation of cellular metabolic functions, gene expression and beneficial effects on lipid profile or blood pressure. The aim of the study is to review the effects of ω-3 PUFA supplemented as fish oil or blue fish in blood pressure. The analysis of different studies suggests that high doses ω-3 PUFA ( ≥  3 g/day) produces a small but significant decrease in blood pressure, especially systolic blood pressure, in older and hypertensive subjects; however, the evidence is not consistent among different studies. ω-3 polyunsaturated fatty acids consumption might have a place in the control of patients with mild hypertension before starting drug treatment and of those who prefer changes of lifestyles like diet.

scholarly journals Plasma and Tissue Bioavailability and Blood Pressure Lowering Effects of Omega-3 Polyunsaturated Fatty Acids from Commonly Eaten, Naturally Enriched, Foods

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Alice Stanton ◽  
Kathleen Shortall ◽  
Thora El-Sayed ◽  
Margaret Brennan ◽  
Fahad Buskandar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Chicken Meat ◽  
Red Cell ◽  
Omega 3 ◽  
Blood Pressure Lowering ◽  
Oily Fish ◽  
Pressure Lowering ◽  
Meat And Eggs

AbstractGreater consumption of oily fish, and elevated plasma levels of the long-chain marine-derived omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been strongly and consistently associated with a reduced incidence of heart attacks, strokes, cognitive decline, Alzheimer's disease and cancers. Despite international guidelines recommending eating oily fish at least once per week (> 250mg/day DHA and EPA), many people do not eat fish, and only a small minority of the world's population have optimal omega-3-PUFA plasma and tissue levels. Hence, in this project, we studied the bioavailability and blood pressure lowering effects of recently developed alternatives to oily fish, namely chicken-meat and eggs naturally enriched with algae-sourced omega-3-PUFAs.This was a double-blinded, controlled, randomised trial. Using a 2X2 factorial design, 161 healthy participants were randomized to eat at least 3 portions/week of omega-3-PUFA enriched (or control) chicken-meat, and to eat at least 3 omega-3-PUFA enriched (or control) eggs/week, for 6 months.Compared to control foods, eating enriched eggs, enriched chicken-meat and the combination for 6 months, resulted in plasma EPA increments (μg/g) of 3.1[2.8], 8.8[2.9]* & 4.7[2.9], plasma DHA increments (μg/g) of 5.1[3.7], 9.3[3.8]* & 13.1[3.9]*, and omega-3-index (sum of EPA + DHA as a percentage of total fatty acids in erythrocytes, %) increments of 0.9[0.3]*, 0.7[0.4]* & 1.5[0.4]*, respectively. Mean 24-hour ambulatory blood pressure (systolic/diastolic, mmHg) declined with the enriched foods 0.3[1.3]/-0.2[1.0], -0.7[1.4]/-1.4[1.0], & -1.9[1.4]/-2.9[1.0]*, respectively. Data provided as mean difference[SEM], and * denotes p < 0.05.Regular consumption of omega-3-PUFA enriched chicken-meat and eggs resulted in statistically significant and clinically relevant increases in plasma and red cell levels of DHA and EPA. Both plasma and red cell bioavailability were similar to those previously described for oily fish. Furthermore, blood pressure, an important biomarker of cardiovascular health, decreased in those eating the omega-3-PUFA enriched foods. Omega-3-PUFA enriched chicken-meat and eggs offers consumers an attractive additional alternative to eating oily fish. Unlike many lifestyle interventions, long-term large population health benefits are not dependent on willingness of people to make long-lasting dietary changes, but on the widespread availability of a range of inexpensive, commonly eaten, naturally enriched foods.

Serum long-chain omega-3 polyunsaturated fatty acids and future blood pressure in an ageing population

2015 ◽  
Vol 19 (5) ◽  
pp. 498-503 ◽  
Author(s):  
A. N. Nyantika ◽  
T. -P. Tuomainen ◽  
J. Kauhanen ◽  
S. Voutilainen ◽  
Jyrki K. Virtanen
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Ageing Population ◽  
Omega 3 ◽  
Long Chain
Sign in / Sign up

Export Citation Format

Share Document