scholarly journals Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model

2011 ◽  
Vol 255 (2) ◽  
pp. 200-206 ◽  
Author(s):  
Jun-Yan Liu ◽  
Hong Qiu ◽  
Christophe Morisseau ◽  
Sung Hee Hwang ◽  
Hsing-Ju Tsai ◽  
...  
Keyword(s):  
Murine Model ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 703 ◽  
Author(s):  
Mercè Pallàs ◽  
Santiago Vázquez ◽  
Coral Sanfeliu ◽  
Carles Galdeano ◽  
Christian Griñán-Ferré
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Epoxide Hydrolase ◽  
Active Role ◽  
Soluble Epoxide Hydrolase ◽  
Hydrolytic Activity ◽  
Neurodegenerative Process ◽  
Anti Inflammatory

Neuroinflammation is a crucial process associated with the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Several pieces of evidence suggest an active role of lipid mediators, especially epoxy-fatty acids (EpFAs), in the genesis and control of neuroinflammation; 14,15-epoxyeicosatrienoic acid (14,15-EET) is one of the most commonly studied EpFAs, with anti-inflammatory properties. Soluble epoxide hydrolase (sEH) is implicated in the hydrolysis of 14,15-EET to its corresponding diol, which lacks anti-inflammatory properties. Preventing EET degradation thus increases its concentration in the brain through sEH inhibition, which represents a novel pharmacological approach to foster the reduction of neuroinflammation and by end neurodegeneration. Recently, it has been shown that sEH levels increase in brains of PD patients. Moreover, the pharmacological inhibition of the hydrolase domain of the enzyme or the use of sEH knockout mice reduced the deleterious effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. This paper overviews the knowledge of sEH and EETs in PD and the importance of blocking its hydrolytic activity, degrading EETs in PD physiopathology. We focus on imperative neuroinflammation participation in the neurodegenerative process in PD and the putative therapeutic role for sEH inhibitors. In this review, we also describe highlights in the general knowledge of the role of sEH in the central nervous system (CNS) and its participation in neurodegeneration. We conclude that sEH is one of the most promising therapeutic strategies for PD and other neurodegenerative diseases with chronic inflammation process, providing new insights into the crucial role of sEH in PD pathophysiology as well as a singular opportunity for drug development.

scholarly journals Anti-inflammatory effect of galectin-1 in a murine model of atopic dermatitis

2017 ◽  
Vol 95 (9) ◽  
pp. 1005-1015 ◽  
Author(s):  
Mab Pereira Corrêa ◽  
Frans Eberth Costa Andrade ◽  
Alexandre Dantas Gimenes ◽  
Cristiane Damas Gil
Keyword(s):  
Atopic Dermatitis ◽  
Murine Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Evidence of an anti-inflammatory effect of mycophenolate mofetil in a murine model of pleurisy

2011 ◽  
Vol 37 (7) ◽  
pp. 399-407 ◽  
Author(s):  
Eduardo Monguilhott Dalmarco ◽  
Caio Maurício Mendes de Córdova ◽  
Tânia Silvia Fröde
Keyword(s):  
Mycophenolate Mofetil ◽  
Murine Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation

2009 ◽  
Vol 156 (2) ◽  
pp. 284-296 ◽  
Author(s):  
Jun-Yan Liu ◽  
Hsing-Ju Tsai ◽  
Sung Hee Hwang ◽  
Paul D Jones ◽  
Christophe Morisseau ◽  
...  
Keyword(s):  
Murine Model ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase Inhibitors
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