Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain

2006 ◽  
Vol 217 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Sanjay Yadav ◽  
Ashu Johri ◽  
Alok Dhawan ◽  
Prahlad K. Seth ◽  
Devendra Parmar
Keyword(s):  
Cytochrome P450 ◽  
Rat Brain ◽  
P450 Expression ◽  
Regional Specificity

scholarly journals The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms

2021 ◽  
Vol 22 (16) ◽  
pp. 8447
Author(s):  
Przemysław J. Danek ◽  
Wojciech Kuban ◽  
Władysława A. Daniel
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Combined Treatment ◽  
Pharmacological Therapy ◽  
Mental Wellbeing ◽  
Cyp Enzymes ◽  
P450 Expression ◽  
Male Wistar Rats ◽  
Expression And Activity

In order to achieve a desired therapeutic effect in schizophrenia patients and to maintain their mental wellbeing, pharmacological therapy needs to be continued for a long time, usually from the onset of symptoms and for the rest of the patients’ lives. The aim of our present research is to find out the in vivo effect of chronic treatment with atypical neuroleptic iloperidone on the expression and activity of cytochrome P450 (CYP) in rat liver. Male Wistar rats received a once-daily intraperitoneal injection of iloperidone (1 mg/kg) for a period of two weeks. Twenty-four hours after the last dose, livers were excised to study cytochrome P450 expression (mRNA and protein) and activity, pituitaries were isolated to determine growth hormone-releasing hormone (GHRH), and blood was collected for measuring serum concentrations of hormones and interleukin. The results showed a broad spectrum of changes in the expression and activity of liver CYP enzymes, which are important for drug metabolism (CYP1A, CYP2B, CYP2C, and CYP3A) and xenobiotic toxicity (CYP2E1). Iloperidone decreased the expression and activity of CYP1A2, CP2B1/2, CYP2C11, and CYP3A1/2 enzymes but increased that of CYP2E1. The CYP2C6 enzyme remained unchanged. At the same time, the level of GHRH, GH, and corticosterone decreased while that of T3 increased, with no changes in IL-2 and IL-6. The presented results indicate neuroendocrine regulation of the investigated CYP enzymes during chronic iloperidone treatment and suggest a possibility of pharmacokinetic/metabolic interactions produced by the neuroleptic during prolonged combined treatment with drugs that are substrates of iloperidone-affected CYP enzymes.

scholarly journals Cytochrome P450 expression and regulation in the brain

2020 ◽  
pp. 1-29
Author(s):  
Wojciech Kuban ◽  
Władysława Anna Daniel
Keyword(s):  
Cytochrome P450 ◽  
P450 Expression ◽  
The Brain

scholarly journals Isoform-specific regulation of cytochrome P450 expression and activity by estradiol in female rats

2011 ◽  
Vol 81 (6) ◽  
pp. 777-782 ◽  
Author(s):  
Su-Young Choi ◽  
Liam Fischer ◽  
Kyunghee Yang ◽  
Hyejin Chung ◽  
Hyunyoung Jeong
Keyword(s):  
Cytochrome P450 ◽  
Female Rats ◽  
P450 Expression ◽  
Specific Regulation ◽  
Expression And Activity

scholarly journals Skeletal Muscle Interleukin-6 Regulates Hepatic Cytochrome P450 Expression: Effects of 16-Week High-Fat Diet and Exercise

2017 ◽  
Vol 162 (1) ◽  
pp. 309-317 ◽  
Author(s):  
Jakob G Knudsen ◽  
Lærke Bertholdt ◽  
Anders Gudiksen ◽  
Sabine Gerbal-Chaloin ◽  
Martin Krøyer Rasmussen
Keyword(s):  
Skeletal Muscle ◽  
Cytochrome P450 ◽  
Interleukin 6 ◽  
High Fat Diet ◽  
High Fat ◽  
Diet And Exercise ◽  
P450 Expression ◽  
Hepatic Cytochrome
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