Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity

2006 ◽  
Vol 216 (1) ◽  
pp. 98-107 ◽  
Author(s):  
C COVER ◽  
J LIU ◽  
A FARHOOD ◽  
E MALLE ◽  
M WAALKES ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Pathophysiological Role ◽  
Acetaminophen Hepatotoxicity

Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals

2015 ◽  
Vol 74 (4) ◽  
pp. 786-790 ◽  
Author(s):  
Nicola Dalbeth ◽  
Bregina Pool ◽  
Odette M Shaw ◽  
Jacquie L Harper ◽  
Paul Tan ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Monosodium Urate ◽  
Monosodium Urate Crystals ◽  
Urate Crystals

scholarly journals Depletion of Neutrophils Exacerbates the Early Inflammatory Immune Response in Lungs of Mice Infected withParacoccidioides brasiliensis

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Paula Andrea Pino-Tamayo ◽  
Juan David Puerta-Arias ◽  
Damaris Lopera ◽  
Martha Eugenia Urán-Jiménez ◽  
Ángel González
Keyword(s):  
Monoclonal Antibody ◽  
Immune Response ◽  
Inflammatory Response ◽  
Paracoccidioides Brasiliensis ◽  
Yeast Cells ◽  
Histopathological Analysis ◽  
Acute Inflammatory Response ◽  
Fungal Load ◽  
Inflammatory Immune Response

Neutrophils predominate during the acute phase of theParacoccidioides brasiliensisinfection. Herein, we determined the role of the neutrophil during the early stages of experimental pulmonary paracoccidioidomycosis using a monoclonal antibody (mAb) specific for neutrophils. Male BALB/c mice were inoculated intranasally with1.5×106or2×106P. brasiliensisyeast cells. The mAb was administered 24 h before infection, followed by doses every 48 h until mice were sacrificed. Survival time was evaluated and mice were sacrificed at 48 h and 96 h after inoculation to assess cellularity, fungal load, cytokine/chemokine levels, and histopathological analysis. Neutrophils from mAb-treated mice were efficiently depleted (99.04%). Eighty percent of the mice treated with the mAb and infected with1.5×106yeast cells died during the first two weeks after infection. When mice were treated and infected with2×106yeast cells, 100% of them succumbed by the first week after infection. During the acute inflammatory response significant increases in numbers of eosinophils, fungal load and levels of proinflammatory cytokines/chemokines were observed in the mAb-treated mice. We also confirmed that neutrophils are an important source of IFN-γand IL-17. These results indicate that neutrophils are essential for protection as well as being important for regulating the early inflammatory immune response in experimental pulmonary paracoccidioidomycosis.

The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom

Toxicon ◽  
2016 ◽  
Vol 118 ◽  
pp. 121-128 ◽  
Author(s):  
Vanessa Moreira ◽  
Catarina Teixeira ◽  
Henrique Borges da Silva ◽  
Maria Regina D'Império Lima ◽  
Maria Cristina Dos-Santos
Keyword(s):  
Inflammatory Response ◽  
Snake Venom ◽  
Acute Inflammatory Response ◽  
Bothrops Atrox

scholarly journals The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Sabine Grösch ◽  
Alice V. Alessenko ◽  
Elisabetta Albi
Keyword(s):  
Biological Activity ◽  
Inflammatory Response ◽  
Immune Cells ◽  
Inflammatory Process ◽  
Acute Inflammatory Response ◽  
Exogenous Agents ◽  
The Many

This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the emerging data that support the different roles of the sphingolipid members in specific phases of inflammation: (1) migration of immune cells, (2) recognition of exogenous agents, and (3) activation/differentiation of immune cells.

scholarly journals Resolution in an ‘over-inflamed’ era

2017 ◽  
Vol 39 (4) ◽  
pp. 4-7
Author(s):  
Mauro Perretti ◽  
Trinidad MonteroMelendez
Keyword(s):  
Inflammatory Response ◽  
Acute Inflammation ◽  
Pharmacological Intervention ◽  
Acute Inflammatory Response ◽  
Moderate Pain ◽  
Antiinflammatory Drugs ◽  
Protective Mechanisms ◽  
Life Saving ◽  
Common Perception

Unlike other pathologies, inflammation is a condition that all individuals experience in their lives. Toothache, sunburn, a twisted ankle or cutting your hand while slicing bread, they all evoke what we call an acute inflammatory response. This type of response normally displays the cardinal signs of inflammation originally described by Aulus Cornelius Celsus: redness, swelling, heat and pain. Acute inflammation does not normally require any therapeutic intervention other than perhaps a painkiller, as it resolves, with the damage being naturally repaired. Inflammation is also at the root of many other diseases in a more ‘silent’ way as the cardinal signs of inflammation are not so evident. It is now appreciated that inflammatory mechanisms and processes contribute to the pathogenesis of a number of conditions including obesity, cancer, rheumatoid arthritis, atherosclerosis and diabetes. These are examples of chronic inflammation, arising either by the persistence of the injurious element causing it, or by a defect in our endogenous natural protective mechanisms grouped under the terminology of pro-resolving mechanisms. A common perception, likely to have been enhanced by the large variety of nonprescription antiinflammatory drugs available to anyone experiencing mild-to-moderate pain, is that inflammation is something harmful that must be stopped. In the next sections we will discuss on the protective life-saving role of the inflammatory response, the existence of our own body's resolutive mechanisms that regulate it and on when and why we need a pharmacological intervention to treat inflammation.

SAT0528 Role of Micrornas in Regulation of the Acute Inflammatory Response to Monosodium Urate Crystals

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 782.2-782
Author(s):  
N. Dalbeth ◽  
B. Pool ◽  
C. Franklin ◽  
M.E. House ◽  
J. Cornish ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Monosodium Urate ◽  
Monosodium Urate Crystals ◽  
Urate Crystals
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