Sterilization of macroscopic poly(l-lactic acid) porous scaffolds with dense carbon dioxide: Investigation of the spatial penetration of the treatment and of its effect on the properties of the matrix

2016 ◽  
Vol 111 ◽  
pp. 83-90 ◽  
Author(s):  
Sonia Lanzalaco ◽  
Simona Campora ◽  
Valerio Brucato ◽  
Francesco Carfì Pavia ◽  
Elvira Rosalia Di Leonardo ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Lactic Acid ◽  
Porous Scaffolds ◽  
Dense Carbon Dioxide ◽  
The Matrix

scholarly journals Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pradeep Kumar ◽  
Viness Pillay ◽  
Yahya E. Choonara
Keyword(s):  
Tissue Engineering ◽  
Polymer Network ◽  
Three Dimensional ◽  
Hysteresis Loops ◽  
Interpenetrating Polymer Network ◽  
Morphological Data ◽  
Porous Scaffolds ◽  
Morphological Variations ◽  
Molecular Stability ◽  
The Matrix

AbstractThree-dimensional porous scaffolds are widely employed in tissue engineering and regenerative medicine for their ability to carry bioactives and cells; and for their platform properties to allow for bridging-the-gap within an injured tissue. This study describes the effect of various methoxypolyethylene glycol (mPEG) derivatives (mPEG (-OCH3 functionality), mPEG-aldehyde (mPEG-CHO) and mPEG-acetic acid (mPEG-COOH)) on the morphology and physical properties of chemically crosslinked, semi-interpenetrating polymer network (IPN), chitosan (CHT)/mPEG blend cryosponges. Physicochemical and molecular characterization revealed that the –CHO and –COOH functional groups in mPEG derivatives interacted with the –NH2 functionality of the chitosan chain. The distinguishing feature of the cryosponges was their unique morphological features such as fringe thread-, pebble-, curved quartz crystal-, crystal flower-; and canyon-like structures. The morphological data was well corroborated by the image processing data and physisorption curves corresponding to Type II isotherm with open hysteresis loops. Functionalization of mPEG had no evident influence on the macro-mechanical properties of the cryosponges but increased the matrix strength as determined by the rheomechanical analyses. The cryosponges were able to deliver bioactives (dexamethasone and curcumin) over 10 days, showed varied matrix degradation profiles, and supported neuronal cells on the matrix surface. In addition, in silico simulations confirmed the compatibility and molecular stability of the CHT/mPEG blend compositions. In conclusion, the study confirmed that significant morphological variations may be induced by minimal functionalization and crosslinking of biomaterials.

Nanocellular and needle-like structures in poly(l-lactic acid) using spherulite templates and supercritical carbon dioxide

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36320-36324 ◽  
Author(s):  
Junsong Li ◽  
Guangjian He ◽  
Xia Liao ◽  
Hao Xu ◽  
Qi Yang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Lactic Acid ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon

The random nanocells and the radial needle-like cells are formed in the interlamellar amorphous regions of spherulites in PLLA.

Consequences of CO2 solubility for hydrate formation from carbon dioxide containing water and other impurities

2014 ◽  
Vol 16 (18) ◽  
pp. 8623-8638 ◽  
Author(s):  
Bjørn Kvamme ◽  
Tatiana Kuznetsova ◽  
Bjørnar Jensen ◽  
Sigvat Stensholt ◽  
Jordan Bauman ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Water Content ◽  
Upper Bound ◽  
Hydrate Formation ◽  
Pipeline Transport ◽  
Co2 Solubility ◽  
Complex Issue ◽  
Dense Carbon Dioxide

Deciding on the upper bound of water content permissible in a stream of dense carbon dioxide under pipeline transport conditions without facing the risks of hydrate formation is a complex issue.

Enzymatic synthesis of L-lactic acid from carbon dioxide and ethanol with an inherent cofactor regeneration cycle

2010 ◽  
Vol 108 (2) ◽  
pp. 465-469 ◽  
Author(s):  
Xiaodong Tong ◽  
Bilal El-Zahab ◽  
Xueyan Zhao ◽  
Youyan Liu ◽  
Ping Wang
Keyword(s):  
Carbon Dioxide ◽  
Lactic Acid ◽  
Enzymatic Synthesis ◽  
Cofactor Regeneration ◽  
Regeneration Cycle

scholarly journals Lactic Acid Formation and Carbon Dioxide Fixation

Nature ◽  
1957 ◽  
Vol 180 (4594) ◽  
pp. 1053-1053 ◽  
Author(s):  
D. A. BARBER
Keyword(s):  
Carbon Dioxide ◽  
Lactic Acid ◽  
Carbon Dioxide Fixation ◽  
Acid Formation

Synthesis of Large-Size Diamonds by Reduction of Dense Carbon Dioxide with Alkali Metals (K, Li)

2004 ◽  
Vol 108 (14) ◽  
pp. 4239-4241 ◽  
Author(s):  
Zhengsong Lou ◽  
Qianwang Chen ◽  
Yufeng Zhang ◽  
Yitai Qian ◽  
Wei Wang
Keyword(s):  
Carbon Dioxide ◽  
Alkali Metals ◽  
Large Size ◽  
Dense Carbon Dioxide
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